The prolonged effect of repeated maternal glucocorticoid exposure on the maternal and fetal leptin/insulin-like growth factor axis in Papio species.

TitleThe prolonged effect of repeated maternal glucocorticoid exposure on the maternal and fetal leptin/insulin-like growth factor axis in Papio species.
Publication TypeJournal Article
Year of Publication2009
AuthorsSchlabritz-Loutsevitch, NE, Lopez-Alvarenga, JC, Comuzzie, AG, Miller, MM, Ford, SP, Li, C, Hubbard, GB, Ferry, RJ, Nathanielsz, PW
JournalReprod Sci
Volume16
Issue3
Pagination308-19
Date Published2009 Mar
ISSN1933-7205
KeywordsAnimals, Betamethasone, Blood Glucose, Body Weight, Cesarean Section, Cholesterol, Drug Administration Schedule, Eating, Female, Fetal Blood, Fetal Weight, Fetus, Gestational Age, Glucocorticoids, Hydrocortisone, Injections, Intramuscular, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Leptin, Maternal-Fetal Exchange, Papio cynocephalus, Placenta, Pregnancy
Abstract

BACKGROUND: Maternal obesity represents a risk factor for pregnancy-related complications. Glucocorticoids are known to promote obesity in adults.METHODS: We evaluated maternal and fetal metabolic changes during and after 3 weekly courses of betamethasone administered to pregnant baboons (Papio subspecies) at doses equivalent to those given to pregnant women.RESULTS: Betamethasone administration during the second half of pregnancy increased maternal weight but neither maternal food intake nor fetal weight, as assessed at the end of gestation. Betamethasone increased maternal serum glucose concentration, the ratio of insulin-like growth factor-I and insulin-like growth factor binding protein-3, and serum leptin during treatment (normalized by 17, 35, and 45 days posttreatment, respectively, for each parameter). Maternal and fetal serum leptin concentrations did not differ between groups at the end of gestation.CONCLUSION: Prolonged maternal hyperleptinemia caused by betamethasone administration in the second half of gestation did not change fetal metabolic parameters measured and placental leptin distribution at the end of gestation.

DOI10.1177/1933719108325755
Alternate JournalReprod Sci
PubMed ID19087979
PubMed Central IDPMC2801412
Grant ListR01 HD21350 / HD / NICHD NIH HHS / United States
P01 HD021350 / HD / NICHD NIH HHS / United States
P01 HD021350-18 / HD / NICHD NIH HHS / United States
K08 DK002876 / DK / NIDDK NIH HHS / United States
P51 RR013986-11S15210 / RR / NCRR NIH HHS / United States
K08 DK02876 / DK / NIDDK NIH HHS / United States
K08 DK002876-06 / DK / NIDDK NIH HHS / United States
P51 RR013986 / RR / NCRR NIH HHS / United States