Quantitative trait loci affecting liver fat content in mice.

TitleQuantitative trait loci affecting liver fat content in mice.
Publication TypeJournal Article
Year of Publication2012
AuthorsMinkina, O, Cheverud, JM, Fawcett, G, Semenkovich, CF, Kenney-Hunt, JP
JournalG3 (Bethesda)
Volume2
Issue9
Pagination1019-25
Date Published2012 Sep
ISSN2160-1836
KeywordsAnimals, Diabetes Mellitus, Diet, Fat-Restricted, Diet, High-Fat, Fats, Fatty Liver, Female, Liver, Male, Mice, Non-alcoholic Fatty Liver Disease, Obesity, Quantitative Trait Loci
Abstract

Nonalcoholic fatty liver disease, a condition in which excess fat accumulates in the liver, is strongly associated with the metabolic syndrome, including obesity and other related conditions. This disease has the potential to progress from steatosis to steatohepatitis, fibrosis, and cirrhosis. The recent increase in the prevalence of the metabolic syndrome is largely driven by changes in diet and activity levels. Individual variation in the response to this obesogenic environment, however, is attributable in part to genetic variation between individuals, but very few mammalian genetic loci have been identified with effects on fat accumulation in the liver. To study the genetic basis for variation in liver fat content in response to dietary fat, liver fat proportion was determined using quantitative magnetic resonance imaging in 478 mice from 16 LG/J X SM/J recombinant inbred strains fed either a high-fat (42% kcal from fat) or low-fat (15% kcal from fat) diet. An analysis of variance confirmed that there is a genetic basis for variation in liver fat content within the population with significant effects of sex and diet. Three quantitative trail loci that contribute to liver fat content also were mapped.

DOI10.1534/g3.112.003343
Alternate JournalG3 (Bethesda)
PubMed ID22973538
PubMed Central IDPMC3429915
Grant ListDK020579 / DK / NIDDK NIH HHS / United States
DK055736 / DK / NIDDK NIH HHS / United States
DK056341 / DK / NIDDK NIH HHS / United States
P30 DK020579 / DK / NIDDK NIH HHS / United States
P30 DK056341 / DK / NIDDK NIH HHS / United States
R01 DK076729 / DK / NIDDK NIH HHS / United States
R01 DK088083 / DK / NIDDK NIH HHS / United States