Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

TitleRefining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
Publication TypeJournal Article
Year of Publication2018
AuthorsMahajan, A, Wessel, J, Willems, SM, Zhao, W, Robertson, NR, Chu, AY, Gan, W, Kitajima, H, Taliun, D, N Rayner, W, Guo, X, Lu, Y, Li, M, Jensen, RA, Hu, Y, Huo, S, Lohman, KK, Zhang, W, Cook, JP, Prins, BPeter, Flannick, J, Grarup, N, Trubetskoy, VVladimirov, Kravic, J, Kim, YJin, Rybin, DV, Yaghootkar, H, Müller-Nurasyid, M, Meidtner, K, Li-Gao, R, Varga, TV, Marten, J, Li, J, Smith, AVernon, An, P, Ligthart, S, Gustafsson, S, Malerba, G, Demirkan, A, Tajes, JFernandez, Steinthorsdottir, V, Wuttke, M, Lecoeur, C, Preuss, M, Bielak, LF, Graff, M, Highland, HM, Justice, AE, Liu, DJ, Marouli, E, Peloso, GMarie, Warren, HR, Afaq, S, Afzal, S, Ahlqvist, E, Almgren, P, Amin, N, Bang, LB, Bertoni, AG, Bombieri, C, Bork-Jensen, J, Brandslund, I, Brody, JA, Burtt, NP, Canouil, M, Chen, Y-DIda, Cho, YShin, Christensen, C, Eastwood, SV, Eckardt, K-U, Fischer, K, Gambaro, G, Giedraitis, V, Grove, ML, de Haan, HG, Hackinger, S, Hai, Y, Han, S, Tybjærg-Hansen, A, Hivert, M-F, Isomaa, B, Jäger, S, Jørgensen, ME, Jørgensen, T, Käräjämäki, A, Kim, B-J, Kim, SSoo, Koistinen, HA, Kovacs, P, Kriebel, J, Kronenberg, F, Läll, K, Lange, LA, Lee, J-J, Lehne, B, Li, H, Lin, K-H, Linneberg, A, Liu, C-T, Liu, J, Loh, M, Mägi, R, Mamakou, V, McKean-Cowdin, R, Nadkarni, G, Neville, M, Nielsen, SF, Ntalla, I, Peyser, PA, Rathmann, W, Rice, K, Rich, SS, Rode, L, Rolandsson, O, Schönherr, S, Selvin, E, Small, KS, Stančáková, A, Surendran, P, Taylor, KD, Teslovich, TM, Thorand, B, Thorleifsson, G, Tin, A, Tonjes, A, Varbo, A, Witte, DR, Wood, AR, Yajnik, P, Yao, J, Yengo, L, Young, R, Amouyel, P, Boeing, H, Boerwinkle, E, Bottinger, EP, Chowdhury, iv, R, Collins, FS, Dedoussis, G, Dehghan, A, Deloukas, P, Ferrario, MM, Ferrieres, J, Florez, JC, Frossard, P, Gudnason, V, Harris, TB, Heckbert, SR, Howson, JMM, Ingelsson, M, Kathiresan, S, Kee, F, Kuusisto, J, Langenberg, C, Launer, LJ, Lindgren, CM, Männistö, S, Meitinger, T, Melander, O, Mohlke, KL, Moitry, M, Morris, AD, Murray, AD, de Mutsert, R, Orho-Melander, M, Owen, KR, Perola, M, Peters, A, Province, MA, Rasheed, A, Ridker, PM, Rivadineira, F, Rosendaal, FR, Rosengren, AH, Salomaa, V, Sheu, WH-H, Sladek, R, Smith, BH, Strauch, K, Uitterlinden, AG, Varma, R, Willer, CJ, Blüher, M, Butterworth, AS, Chambers, JCampbell, Chasman, DI, Danesh, J, van Duijn, C, Dupuis, J, Franco, OH, Franks, PW, Froguel, P, Grallert, H, Groop, L, Han, B-G, Hansen, T, Hattersley, AT, Hayward, C, Ingelsson, E, Kardia, SLR, Karpe, F, Kooner, JSingh, Köttgen, A, Kuulasmaa, K, Laakso, M, Lin, X, Lind, L, Liu, Y, Loos, RJF, Marchini, J, Metspalu, A, Mook-Kanamori, D, Nordestgaard, BG, Palmer, CNA, Pankow, JS, Pedersen, O, Psaty, BM, Rauramaa, R, Sattar, N, Schulze, MB, Soranzo, N, Spector, TD, Stefansson, K, Stumvoll, M, Thorsteinsdottir, U, Tuomi, T, Tuomilehto, J, Wareham, NJ, Wilson, JG, Zeggini, E, Scott, RA, Barroso, I, Frayling, TM, Goodarzi, MO, Meigs, JB, Boehnke, M, Saleheen, D, Morris, AP, Rotter, JI, McCarthy, MI
Corporate AuthorsExomeBP Consortium, MAGIC Consortium, GIANT Consortium
JournalNat Genet
Volume50
Issue4
Pagination559-571
Date Published2018 04
ISSN1546-1718
KeywordsAlleles, Chromosome Mapping, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Male, Whole Exome Sequencing
Abstract

We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P 
DOI10.1038/s41588-018-0084-1
Alternate JournalNat Genet
PubMed ID29632382
PubMed Central IDPMC5898373
Grant ListG0601463 / MRC_ / Medical Research Council / United Kingdom
RG/13/13/30194 / BHF_ / British Heart Foundation / United Kingdom
U01 DK085545 / DK / NIDDK NIH HHS / United States
R01 DK098032 / DK / NIDDK NIH HHS / United States
R35 HL135824 / HL / NHLBI NIH HHS / United States
MR/L003120/1 / MRC_ / Medical Research Council / United Kingdom
P30 DK063491 / DK / NIDDK NIH HHS / United States
K24 DK080140 / DK / NIDDK NIH HHS / United States
U01 DK078616 / DK / NIDDK NIH HHS / United States
U01 DK062370 / DK / NIDDK NIH HHS / United States
P30 DK116074 / DK / NIDDK NIH HHS / United States
U54 GM115428 / GM / NIGMS NIH HHS / United States
R01 DK093757 / DK / NIDDK NIH HHS / United States
R01 DK078616 / DK / NIDDK NIH HHS / United States
MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom
U01 HL130114 / HL / NHLBI NIH HHS / United States
MR/K023241/1 / MRC_ / Medical Research Council / United Kingdom
MR/L020149/1 / MRC_ / Medical Research Council / United Kingdom
R01 DK072193 / DK / NIDDK NIH HHS / United States
R00 HL130580 / HL / NHLBI NIH HHS / United States
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom
R01 HL119443 / HL / NHLBI NIH HHS / United States
R01 DK062370 / DK / NIDDK NIH HHS / United States
U01 DK105535 / DK / NIDDK NIH HHS / United States
MR/S003746/1 / MRC_ / Medical Research Council / United Kingdom
MC_PC_U127561128 / MRC_ / Medical Research Council / United Kingdom
P30 DK020572 / DK / NIDDK NIH HHS / United States
RG/14/5/30893 / BHF_ / British Heart Foundation / United Kingdom
MR/K007017/1 / MRC_ / Medical Research Council / United Kingdom
P20 GM121334 / GM / NIGMS NIH HHS / United States
MC_PC_13040 / MRC_ / Medical Research Council / United Kingdom
UL1 TR001881 / TR / NCATS NIH HHS / United States
T32 HL007055 / HL / NHLBI NIH HHS / United States
G0601261 / MRC_ / Medical Research Council / United Kingdom