Requirement for homologous recombination functions for expression of the mutA mistranslator tRNA-induced mutator phenotype in Escherichia coli.

TitleRequirement for homologous recombination functions for expression of the mutA mistranslator tRNA-induced mutator phenotype in Escherichia coli.
Publication TypeJournal Article
Year of Publication2000
AuthorsRen, L, Mamun, AA al, Humayun, MZ
JournalJ Bacteriol
Volume182
Issue5
Pagination1427-31
Date Published2000 Mar
ISSN0021-9193
KeywordsBacterial Proteins, DNA Helicases, DNA-Binding Proteins, Endodeoxyribonucleases, Escherichia coli, Escherichia coli Proteins, Exodeoxyribonuclease V, Exodeoxyribonucleases, Gene Expression Regulation, Bacterial, Genes, Bacterial, Mutation, Phenotype, Rec A Recombinases, Recombination, Genetic, RNA, Transfer, Signal Transduction
Abstract

Expression of the Escherichia coli mutA mutator phenotype requires recA, recB, recC, ruvA, and ruvC gene, but not recD, recF, recO, or recR genes. Thus, the recBCD-dependent homologous recombination system is a component of the signal pathway that activates an error-prone DNA polymerase in mutA cells.

Alternate JournalJ. Bacteriol.
PubMed ID10671469
PubMed Central IDPMC94434
Grant ListR01 CA073026 / CA / NCI NIH HHS / United States
R01 GM058253 / GM / NIGMS NIH HHS / United States
R01 CA73026 / CA / NCI NIH HHS / United States
R01 GM58253 / GM / NIGMS NIH HHS / United States