Title | Requirement for homologous recombination functions for expression of the mutA mistranslator tRNA-induced mutator phenotype in Escherichia coli. |
Publication Type | Journal Article |
Year of Publication | 2000 |
Authors | Ren, L, Mamun, AA al, Humayun, MZ |
Journal | J Bacteriol |
Volume | 182 |
Issue | 5 |
Pagination | 1427-31 |
Date Published | 2000 Mar |
ISSN | 0021-9193 |
Keywords | Bacterial Proteins, DNA Helicases, DNA-Binding Proteins, Endodeoxyribonucleases, Escherichia coli, Escherichia coli Proteins, Exodeoxyribonuclease V, Exodeoxyribonucleases, Gene Expression Regulation, Bacterial, Genes, Bacterial, Mutation, Phenotype, Rec A Recombinases, Recombination, Genetic, RNA, Transfer, Signal Transduction |
Abstract | Expression of the Escherichia coli mutA mutator phenotype requires recA, recB, recC, ruvA, and ruvC gene, but not recD, recF, recO, or recR genes. Thus, the recBCD-dependent homologous recombination system is a component of the signal pathway that activates an error-prone DNA polymerase in mutA cells. |
DOI | 10.1128/JB.182.5.1427-1431.2000 |
Alternate Journal | J Bacteriol |
PubMed ID | 10671469 |
PubMed Central ID | PMC94434 |
Grant List | R01 CA073026 / CA / NCI NIH HHS / United States R01 GM058253 / GM / NIGMS NIH HHS / United States R01 CA73026 / CA / NCI NIH HHS / United States R01 GM58253 / GM / NIGMS NIH HHS / United States |
Requirement for homologous recombination functions for expression of the mutA mistranslator tRNA-induced mutator phenotype in Escherichia coli.
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