Research ethics and the challenge of whole-genome sequencing.

TitleResearch ethics and the challenge of whole-genome sequencing.
Publication TypeJournal Article
Year of Publication2008
AuthorsMcGuire, AL, Caulfield, T, Cho, MK
JournalNat Rev Genet
Volume9
Issue2
Pagination152-6
Date Published2008 02
ISSN1471-0064
KeywordsEthics, Research, Family, Genome, Human, Health Planning Guidelines, Humans, Molecular Sequence Data, Public Policy, Publishing, Research, Research Subjects, Sequence Analysis, DNA, Third-Party Consent
Abstract

The recent completion of the first two individual whole-genome sequences is a research milestone. As personal genome research advances, investigators and international research bodies must ensure ethical research conduct. We identify three major ethical considerations that have been implicated in whole-genome research: the return of research results to participants; the obligations, if any, that are owed to participants' relatives; and the future use of samples and data taken for whole-genome sequencing. Although the issues are not new, we discuss their implications for personal genomics and provide recommendations for appropriate management in the context of research involving individual whole-genome sequencing.

DOI10.1038/nrg2302
Alternate JournalNat. Rev. Genet.
PubMed ID18087293
PubMed Central IDPMC2225443
Grant List5P50HG003389 / HG / NHGRI NIH HHS / United States
R01 HG004333 / HG / NHGRI NIH HHS / United States
P50 HG003389-04 / HG / NHGRI NIH HHS / United States
R01HG004333 / HG / NHGRI NIH HHS / United States
P50 HG003389 / HG / NHGRI NIH HHS / United States