The Role of Ceramide in Inherited Retinal Disease Pathology.

TitleThe Role of Ceramide in Inherited Retinal Disease Pathology.
Publication TypeJournal Article
Year of Publication2023
AuthorsQian, X, Srinivasan, T, He, J, Chen, R
JournalAdv Exp Med Biol
Date Published2023
KeywordsCeramides, Humans, Photoreceptor Cells, Retina, Retinal Degeneration, Retinal Dystrophies

Ceramide (Cer) plays an essential role in photoreceptor cell death in the retina. On the one hand, Cer accumulation emerges as a common feature during retina neurodegeneration, leading to the death of photoreceptors. On the other hand, Cer deficiency has also recently been associated with retinal dysfunction and degeneration. Although more and more evidence supports the importance of maintaining Cer homeostasis in the retina, mechanistic explanations of the observed phenotypes, especially in the context of Cer deficiency, are still lacking. An enhanced understanding of Cer's role in the retina will help us explore the underlying molecular basis for clinical phenotypes of retinal dystrophies and provide us with potential therapeutic targets.

Alternate JournalAdv Exp Med Biol
PubMed ID37440049
PubMed Central ID2271043

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