|Title||Scale-invariant structure of strongly conserved sequence in genomic intersections and alignments.|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Salerno, W, Havlak, P, Miller, J|
|Journal||Proc Natl Acad Sci U S A|
|Date Published||2006 Aug 29|
|Keywords||Animals, Base Sequence, Cluster Analysis, Conserved Sequence, Genome, Genomics, Humans, Mice, Repetitive Sequences, Nucleic Acid, Sequence Alignment|
A power-law distribution of the length of perfectly conserved sequence from mouse/human whole-genome intersection and alignment is exhibited. Spatial correlations of these elements within the mouse genome are studied. It is argued that these power-law distributions and correlations are comprised in part by functional noncoding sequence and ought to be accounted for in estimating the statistical significance of apparent sequence conservation. These inter-genomic correlations of conservation are placed in the context of previously observed intra-genomic correlations, and their possible origins and consequences are discussed.
|Alternate Journal||Proc Natl Acad Sci U S A|
|PubMed Central ID||PMC1559763|
|Grant List||U54 HG003273 / HG / NHGRI NIH HHS / United States |
1 U01 HG003273 / HG / NHGRI NIH HHS / United States
Scale-invariant structure of strongly conserved sequence in genomic intersections and alignments.
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