Scale-invariant structure of strongly conserved sequence in genomic intersections and alignments.

TitleScale-invariant structure of strongly conserved sequence in genomic intersections and alignments.
Publication TypeJournal Article
Year of Publication2006
AuthorsSalerno, WJ, Havlak, P, Miller, J
JournalProc Natl Acad Sci U S A
Volume103
Issue35
Pagination13121-5
Date Published2006 Aug 29
ISSN0027-8424
KeywordsAnimals, Base Sequence, Cluster Analysis, Conserved Sequence, Genome, Genomics, Humans, Mice, Repetitive Sequences, Nucleic Acid, Sequence Alignment
Abstract

A power-law distribution of the length of perfectly conserved sequence from mouse/human whole-genome intersection and alignment is exhibited. Spatial correlations of these elements within the mouse genome are studied. It is argued that these power-law distributions and correlations are comprised in part by functional noncoding sequence and ought to be accounted for in estimating the statistical significance of apparent sequence conservation. These inter-genomic correlations of conservation are placed in the context of previously observed intra-genomic correlations, and their possible origins and consequences are discussed.

DOI10.1073/pnas.0605735103
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID16924100
PubMed Central IDPMC1559763
Grant ListU54 HG003273 / HG / NHGRI NIH HHS / United States
1 U01 HG003273 / HG / NHGRI NIH HHS / United States