Scale-invariant structure of strongly conserved sequence in genomic intersections and alignments.

Title	Scale-invariant structure of strongly conserved sequence in genomic intersections and alignments.
Publication Type	Journal Article
Year of Publication	2006
Authors	Salerno, W, Havlak, P, Miller, J
Journal	Proc Natl Acad Sci U S A
Volume	103
Issue	35
Pagination	13121-5
Date Published	2006 Aug 29
ISSN	0027-8424
Keywords	Animals, Base Sequence, Cluster Analysis, Conserved Sequence, Genome, Genomics, Humans, Mice, Repetitive Sequences, Nucleic Acid, Sequence Alignment
Abstract	A power-law distribution of the length of perfectly conserved sequence from mouse/human whole-genome intersection and alignment is exhibited. Spatial correlations of these elements within the mouse genome are studied. It is argued that these power-law distributions and correlations are comprised in part by functional noncoding sequence and ought to be accounted for in estimating the statistical significance of apparent sequence conservation. These inter-genomic correlations of conservation are placed in the context of previously observed intra-genomic correlations, and their possible origins and consequences are discussed.
DOI	10.1073/pnas.0605735103
Alternate Journal	Proc Natl Acad Sci U S A
PubMed ID	16924100
PubMed Central ID	PMC1559763
Grant List	U54 HG003273 / HG / NHGRI NIH HHS / United States 1 U01 HG003273 / HG / NHGRI NIH HHS / United States