Title | The sheep genome illuminates biology of the rumen and lipid metabolism. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Jiang, Y, Xie, M, Chen, W, Talbot, R, Maddox, JF, Faraut, T, Wu, C, Muzny, DM, Li, Y, Zhang, W, Stanton, J-A, Brauning, R, Barris, WC, Hourlier, T, Aken, BL, Searle, SMJ, Adelson, DL, Bian, C, Cam, GR, Chen, Y, Cheng, S, DeSilva, U, Dixen, K, Dong, Y, Fan, G, Franklin, IR, Fu, S, Guan, R, Highland, MA, Holder, ME, Huang, G, Ingham, AB, Jhangiani, SN, Kalra, D, Kovar, CL, Lee, SL, Liu, W, Liu, X, Lu, C, Lv, T, Mathew, T, McWilliam, S, Menzies, M, Pan, S, Robelin, D, Servin, B, Townley, D, Wang, W, Wei, B, White, SN, Yang, X, Ye, C, Yue, Y, Zeng, P, Zhou, Q, Hansen, JB, Kristensen, K, Gibbs, RA, Flicek, P, Warkup, CC, Jones, HE, V Oddy, H, Nicholas, FW, McEwan, JC, Kijas, J, Wang, J, Worley, KC, Archibald, AL, Cockett, N, Xu, X, Wang, W, Dalrymple, BP |
Journal | Science |
Volume | 344 |
Issue | 6188 |
Pagination | 1168-1173 |
Date Published | 2014 Jun 06 |
ISSN | 1095-9203 |
Keywords | Amino Acid Sequence, Animals, Fatty Acids, Volatile, Gene Expression Regulation, Genome, Keratins, Hair-Specific, Lipid Metabolism, Molecular Sequence Data, Phylogeny, Rumen, Sheep, Domestic, Transcriptome, Wool |
Abstract | Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals. |
DOI | 10.1126/science.1252806 |
Alternate Journal | Science |
PubMed ID | 24904168 |
PubMed Central ID | PMC4157056 |
Grant List | BB/I025328/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom BBS/E/D/20211550 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom U54 HG003273 / HG / NHGRI NIH HHS / United States BB/1025360/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom 095908 / / Wellcome Trust / United Kingdom BB/I025360/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom BBS/E/D/20211552 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom / / Wellcome Trust / United Kingdom BB/I025506/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom BBS/E/D/05191130 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom 098051 / / Wellcome Trust / United Kingdom |
The sheep genome illuminates biology of the rumen and lipid metabolism.
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