Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study.

TitleSingle nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2008
AuthorsMorrison, AC, Bare, LA, Luke, MM, Pankow, JS, Mosley, TH, Devlin, JJ, Willerson, JT, Boerwinkle, E
JournalCerebrovasc Dis
Volume26
Issue4
Pagination420-4
Date Published2008
ISSN1421-9786
KeywordsAfrican Continental Ancestry Group, Brain Ischemia, Coronary Disease, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genotype, Humans, Incidence, Intracranial Arteriosclerosis, Male, Middle Aged, Myocardial Infarction, Neoplasm Proteins, Polymorphism, Single Nucleotide, Predictive Value of Tests, Proportional Hazards Models, Risk Factors, Serpins, Stroke
Abstract

Ischemic stroke and coronary heart disease (CHD) may share genetic factors contributing to a common etiology. This study investigates whether 51 single nucleotide polymorphisms (SNPs) associated with CHD in multiple antecedent studies are associated with incident ischemic stroke in the Atherosclerosis Risk in Communities (ARIC) study. From the multiethnic ARIC cohort of 14,215 individuals, 495 validated ischemic strokes were identified. Cox proportional hazards models, adjusted for age and gender, identified three SNPs in Whites and two SNPs in Blacks associated with incident stroke (p

DOI10.1159/000155637
Alternate JournalCerebrovasc. Dis.
PubMed ID18799872
PubMed Central IDPMC2662496
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
U01 HL075572-04 / HL / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
U01 HL075572 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States