Title | Single stimulus fMRI produces a neural individual difference measure for Autism Spectrum Disorder. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Lu, J, Kishida, K, Cruz, JDe Asis, Lohrenz, T, Deering, DTreadwell, Beauchamp, M, P Montague, R |
Journal | Clin Psychol Sci |
Volume | 3 |
Issue | 3 |
Pagination | 422-432 |
Date Published | 2015 May 01 |
ISSN | 2167-7026 |
Abstract | Functional magnetic resonance imaging typically makes inferences about neural substrates of cognitive phenomena at the group level. We report the use of a single-stimulus BOLD response in the cingulate cortex that differentiates individual children with autism spectrum disorder from matched typically developing control children with sensitivity and specificity of 63.6% and 73.7% respectively. The approach consists of passive viewing of 'self' and 'other' faces from which an individual difference measure is derived from the BOLD response to the first 'self' image only; the method, penalized logistic regression, requires no averaging over stimulus presentations or individuals. These findings show that single-stimulus fMRI responses can be extracted from individual subjects and used profitably as a neural individual difference measure. The result suggests that single-stimulus fMRI can be developed to produce quantitative neural biomarkers for other developmental disorders and may even be useful in the rapid typing of cognition in healthy individuals. |
DOI | 10.1177/2167702614562042 |
Alternate Journal | Clin Psychol Sci |
PubMed ID | 26722624 |
PubMed Central ID | PMC4692192 |
Grant List | R01 MH085496 / MH / NIMH NIH HHS / United States 091188 / / Wellcome Trust / United Kingdom R01 DA011723 / DA / NIDA NIH HHS / United States T32 NS043124 / NS / NINDS NIH HHS / United States F30 MH098571 / MH / NIMH NIH HHS / United States |