Stress, genomes, and evolution.

TitleStress, genomes, and evolution.
Publication TypeJournal Article
Year of Publication2010
AuthorsMittelman, D, Wilson, JH
JournalCell Stress Chaperones
Date Published2010 Sep
KeywordsCell Line, Evolution, Molecular, Genome, Human, HSP90 Heat-Shock Proteins, Humans, Microsatellite Instability, Rad51 Recombinase, Stress, Physiological, Trinucleotide Repeats

Evolutionary change, whether in populations of organisms or malignant tumor cells, is contingent on the availability of inherited variation for natural selection to act upon. It is becoming clear that the Hsp90 chaperone, which normally functions to buffer client proteins against the effects of genetic variation, plays a central role in this process. Severe environmental stress can overwhelm the chaperone's buffering capacity, causing previously cryptic genetic variation to be expressed. Recent studies now indicate that in addition to exposing existing variation, Hsp90 can induce novel epigenetic and genetic changes. We discuss key findings that suggest a rich set of pathways by which Hsp90 can mediate the influences of the environment on the genome.

Alternate JournalCell Stress Chaperones
PubMed ID20521130
PubMed Central IDPMC3006615
Grant ListF32 NS064762 / NS / NINDS NIH HHS / United States
R01 GM038219 / GM / NIGMS NIH HHS / United States
GM38219 / GM / NIGMS NIH HHS / United States
NS064762 / NS / NINDS NIH HHS / United States