Title | Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Davies, G, Lam, M, Harris, SE, Trampush, JW, Luciano, M, W Hill, D, Hagenaars, SP, Ritchie, SJ, Marioni, RE, Fawns-Ritchie, C, Liewald, DCM, Okely, JA, Ahola-Olli, AV, Barnes, CLK, Bertram, L, Bis, JC, Burdick, KE, Christoforou, A, DeRosse, P, Djurovic, S, Espeseth, T, Giakoumaki, S, Giddaluru, S, Gustavson, DE, Hayward, C, Hofer, E, M Ikram, A, Karlsson, R, Knowles, E, Lahti, J, Leber, M, Li, S, Mather, KA, Melle, I, Morris, D, Oldmeadow, C, Palviainen, T, Payton, A, Pazoki, R, Petrovic, K, Reynolds, CA, Sargurupremraj, M, Scholz, M, Smith, JA, Smith, AV, Terzikhan, N, Thalamuthu, A, Trompet, S, van der Lee, SJ, Ware, EB, B Windham, G, Wright, MJ, Yang, J, Yu, J, Ames, D, Amin, N, Amouyel, P, Andreassen, OA, Armstrong, NJ, Assareh, AA, Attia, JR, Attix, D, Avramopoulos, D, Bennett, DA, Böhmer, AC, Boyle, PA, Brodaty, H, Campbell, H, Cannon, TD, Cirulli, ET, Congdon, E, Conley, EDrabant, Corley, J, Cox, SR, Dale, AM, Dehghan, A, Dick, D, Dickinson, D, Eriksson, JG, Evangelou, E, Faul, JD, Ford, I, Freimer, NA, Gao, H, Giegling, I, Gillespie, NA, Gordon, SD, Gottesman, RF, Griswold, ME, Gudnason, V, Harris, TB, Hartmann, AM, Hatzimanolis, A, Heiss, G, Holliday, EG, Joshi, PK, Kähönen, M, Kardia, SLR, Karlsson, I, Kleineidam, L, Knopman, DS, Kochan, NA, Konte, B, Kwok, JB, Le Hellard, S, Lee, T, Lehtimäki, T, Li, S-C, Lill, CM, Liu, T, Koini, M, London, E, Longstreth, WT, Lopez, OL, Loukola, A, Luck, T, Lundervold, AJ, Lundquist, A, Lyytikäinen, L-P, Martin, NG, Montgomery, GW, Murray, AD, Need, AC, Noordam, R, Nyberg, L, Ollier, W, Papenberg, G, Pattie, A, Polasek, O, Poldrack, RA, Psaty, BM, Reppermund, S, Riedel-Heller, SG, Rose, RJ, Rotter, JI, Roussos, P, Rovio, SP, Saba, Y, Sabb, FW, Sachdev, PS, Satizabal, CL, Schmid, M, Scott, RJ, Scult, MA, Simino, J, P Slagboom, E, Smyrnis, N, Soumaré, A, Stefanis, NC, Stott, DJ, Straub, RE, Sundet, K, Taylor, AM, Taylor, KD, Tzoulaki, I, Tzourio, C, Uitterlinden, A, Vitart, V, Voineskos, AN, Kaprio, J, Wagner, M, Wagner, H, Weinhold, L, K Wen, H, Widen, E, Yang, Q, Zhao, W, Adams, HHH, Arking, DE, Bilder, RM, Bitsios, P, Boerwinkle, E, Chiba-Falek, O, Corvin, A, De Jager, PL, Debette, S, Donohoe, G, Elliott, P, Fitzpatrick, AL, Gill, M, Glahn, DC, Hägg, S, Hansell, NK, Hariri, AR, M Ikram, K, J Jukema, W, Vuoksimaa, E, Keller, MC, Kremen, WS, Launer, L, Lindenberger, U, Palotie, A, Pedersen, NL, Pendleton, N, Porteous, DJ, Räikkönen, K, Raitakari, OT, Ramirez, A, Reinvang, I, Rudan, I, Schmidt, R, Schmidt, H, Schofield, PW, Schofield, PR, Starr, JM, Steen, VM, Trollor, JN, Turner, ST, van Duijn, CM, Villringer, A, Weinberger, DR, Weir, DR, Wilson, JF, Malhotra, A, McIntosh, AM, Gale, CR, Seshadri, S, Mosley, TH, Bressler, J, Lencz, T, Deary, IJ |
Journal | Nat Commun |
Volume | 9 |
Issue | 1 |
Pagination | 2098 |
Date Published | 2018 05 29 |
ISSN | 2041-1723 |
Keywords | Adolescent, Adult, Aged, Aged, 80 and over, Cognition, Genetic Loci, Genetic Predisposition to Disease, Humans, Mental Disorders, Middle Aged, Multifactorial Inheritance, Neurodegenerative Diseases, Neurodevelopmental Disorders, Polymorphism, Single Nucleotide, Reaction Time, Young Adult |
Abstract | General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P |
DOI | 10.1038/s41467-018-04362-x |
Alternate Journal | Nat Commun |
PubMed ID | 29844566 |
PubMed Central ID | PMC5974083 |
Grant List | MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom MC_U147585827 / MRC_ / Medical Research Council / United Kingdom U01 AG009740 / AG / NIA NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States MC_UU_12011/2 / MRC_ / Medical Research Council / United Kingdom R01 MH085018 / MH / NIMH NIH HHS / United States MR/K026992/1 / MRC_ / Medical Research Council / United Kingdom MR/S015132/1 / MRC_ / Medical Research Council / United Kingdom U01 HL096814 / HL / NHLBI NIH HHS / United States R01 AG055406 / AG / NIA NIH HHS / United States U01 AG052409 / AG / NIA NIH HHS / United States MC_UU_12011/4 / MRC_ / Medical Research Council / United Kingdom U01 AG049505 / AG / NIA NIH HHS / United States U01 HL096812 / HL / NHLBI NIH HHS / United States R01 NS017950 / NS / NINDS NIH HHS / United States R01 AG054076 / AG / NIA NIH HHS / United States R01 AG049789 / AG / NIA NIH HHS / United States RF1 AG015819 / AG / NIA NIH HHS / United States MC_QA137853 / MRC_ / Medical Research Council / United Kingdom U01 HL130114 / HL / NHLBI NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States MC_U147585819 / MRC_ / Medical Research Council / United Kingdom R01 HL105756 / HL / NHLBI NIH HHS / United States MC_UP_A620_1014 / MRC_ / Medical Research Council / United Kingdom P30 AG010161 / AG / NIA NIH HHS / United States R01 AG033193 / AG / NIA NIH HHS / United States MC_UP_A620_1017 / MRC_ / Medical Research Council / United Kingdom MC_UU_12011/1 / MRC_ / Medical Research Council / United Kingdom R01 HL070825 / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States P30 AG010129 / AG / NIA NIH HHS / United States MC_PC_17228 / MRC_ / Medical Research Council / United Kingdom BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom UL1 TR001881 / TR / NCATS NIH HHS / United States G0400491 / MRC_ / Medical Research Council / United Kingdom G0600237 / MRC_ / Medical Research Council / United Kingdom G0100594 / MRC_ / Medical Research Council / United Kingdom U54 GM115428 / GM / NIGMS NIH HHS / United States MC_U147585824 / MRC_ / Medical Research Council / United Kingdom BB/F022441/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom G0901461 / MRC_ / Medical Research Council / United Kingdom |