Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium.

TitleTargeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium.
Publication TypeJournal Article
Year of Publication2015
AuthorsJalali, A, E Amirian, S, Bainbridge, MN, Armstrong, GN, Liu, Y, Tsavachidis, S, Jhangiani, SN, Plon, SE, Lau, CC, Claus, EB, Barnholtz-Sloan, JS, Il'yasova, D, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Johansen, C, Houlston, RS, Jenkins, RB, Lachance, D, Olson, SH, Bernstein, JL, Merrell, RT, Wrensch, MR, Davis, FG, Lai, R, Shete, S, Aldape, K, Amos, CI, Muzny, DM, Gibbs, RA, Melin, BS, Bondy, ML
JournalSci Rep
Volume5
Pagination8278
Date Published2015 Feb 05
ISSN2045-2322
KeywordsAdult, Brain Neoplasms, Chromosomes, Human, Pair 17, Family, Female, Genetic Linkage, Genetic Variation, Glioma, Humans, Male, Middle Aged, Mutation, Pedigree, Sequence Analysis, DNA, Young Adult
Abstract

Glioma is a rare, but highly fatal, cancer that accounts for the majority of malignant primary brain tumors. Inherited predisposition to glioma has been consistently observed within non-syndromic families. Our previous studies, which involved non-parametric and parametric linkage analyses, both yielded significant linkage peaks on chromosome 17q. Here, we use data from next generation and Sanger sequencing to identify familial glioma candidate genes and variants on chromosome 17q for further investigation. We applied a filtering schema to narrow the original list of 4830 annotated variants down to 21 very rare (

DOI10.1038/srep08278
Alternate JournalSci Rep
PubMed ID25652157
PubMed Central IDPMC4317686
Grant ListR01CA126831 / CA / NCI NIH HHS / United States
P30 CA016672 / CA / NCI NIH HHS / United States
R01CA070917 / CA / NCI NIH HHS / United States
U54HG003273 / HG / NHGRI NIH HHS / United States
K23 CA158148 / CA / NCI NIH HHS / United States
5 P30CA125123 / CA / NCI NIH HHS / United States
R01 CA126831 / CA / NCI NIH HHS / United States
P30CA125123 / CA / NCI NIH HHS / United States
U54 HG003273 / HG / NHGRI NIH HHS / United States
R25 NS070694 / NS / NINDS NIH HHS / United States
P30 CA023108 / CA / NCI NIH HHS / United States
5 R01CA138836 / CA / NCI NIH HHS / United States
R01 CA138836 / CA / NCI NIH HHS / United States
P30 CA125123 / CA / NCI NIH HHS / United States
P50 CA097257 / CA / NCI NIH HHS / United States
R01 CA070917 / CA / NCI NIH HHS / United States
R25NS070694 / NS / NINDS NIH HHS / United States
R01 CA119215 / CA / NCI NIH HHS / United States
R01CA52689 / CA / NCI NIH HHS / United States
R01CA119215 / CA / NCI NIH HHS / United States
P50097257 / / PHS HHS / United States
K23CA158148 / CA / NCI NIH HHS / United States
R01 CA052689 / CA / NCI NIH HHS / United States