Therapy-related Acute Leukemia With Mixed Phenotype and Novel t(1: 6)(q25;p23) After Treatment for High-risk Neuroblastoma.

TitleTherapy-related Acute Leukemia With Mixed Phenotype and Novel t(1: 6)(q25;p23) After Treatment for High-risk Neuroblastoma.
Publication TypeJournal Article
Year of Publication2017
AuthorsWhittle, SB, Punia, JN, López-Terrada, D, Gaikwad, A, Hampton, OA, Heczey, A
JournalJ Pediatr Hematol Oncol
Volume39
Issue8
Paginatione486-e488
Date Published2017 11
ISSN1536-3678
KeywordsAntineoplastic Combined Chemotherapy Protocols, Biopsy, Bone Marrow, Child, Preschool, Chromosome Banding, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 6, Fatal Outcome, Female, Hematopoietic Stem Cell Transplantation, Humans, Immunophenotyping, Leukemia, Myeloid, Acute, Myelodysplastic Syndromes, Neoplasms, Second Primary, Neuroblastoma, Phenotype, Translocation, Genetic, Transplantation Conditioning
Abstract

Neuroblastoma is the most common extracranial malignancy of childhood. Patients with high-risk disease receive multimodal treatment including chemotherapy combinations containing alkylating agents and topoisomerase inhibitors with potential for inducing therapy-related malignancy later in life. Most commonly, cytogenetic changes of pediatric therapy-related myelodysplastic syndrome/acute myeloid leukemia involve chromosome 5 or 7. Here we report a novel case of therapy-related myelodysplastic syndrome/acute myeloid leukemia 30 months after treatment for high-risk neuroblastoma with biphenotypic cell surface markers and a not yet described translocation t(1;6)(q25;p23).

DOI10.1097/MPH.0000000000000956
Alternate JournalJ Pediatr Hematol Oncol
PubMed ID28902076

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