| Title | Therapy-related Acute Leukemia With Mixed Phenotype and Novel t(1: 6)(q25;p23) After Treatment for High-risk Neuroblastoma. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Whittle, SB, Punia, JN, López-Terrada, D, Gaikwad, A, Hampton, OA, Heczey, A |
| Journal | J Pediatr Hematol Oncol |
| Volume | 39 |
| Issue | 8 |
| Pagination | e486-e488 |
| Date Published | 2017 Nov |
| ISSN | 1536-3678 |
| Keywords | Antineoplastic Combined Chemotherapy Protocols, Biopsy, Bone Marrow, Child, Preschool, Chromosome Banding, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 6, Fatal Outcome, Female, Hematopoietic Stem Cell Transplantation, Humans, Immunophenotyping, Leukemia, Myeloid, Acute, Myelodysplastic Syndromes, Neoplasms, Second Primary, Neuroblastoma, Phenotype, Translocation, Genetic, Transplantation Conditioning |
| Abstract | Neuroblastoma is the most common extracranial malignancy of childhood. Patients with high-risk disease receive multimodal treatment including chemotherapy combinations containing alkylating agents and topoisomerase inhibitors with potential for inducing therapy-related malignancy later in life. Most commonly, cytogenetic changes of pediatric therapy-related myelodysplastic syndrome/acute myeloid leukemia involve chromosome 5 or 7. Here we report a novel case of therapy-related myelodysplastic syndrome/acute myeloid leukemia 30 months after treatment for high-risk neuroblastoma with biphenotypic cell surface markers and a not yet described translocation t(1;6)(q25;p23).
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| DOI | 10.1097/MPH.0000000000000956 |
| Alternate Journal | J Pediatr Hematol Oncol |
| PubMed ID | 28902076 |
| Grant List | K12 CA090433 / CA / NCI NIH HHS / United States |