The trans-ancestral genomic architecture of glycemic traits.

TitleThe trans-ancestral genomic architecture of glycemic traits.
Publication TypeJournal Article
Year of Publication2021
AuthorsChen, J, Spracklen, CN, Marenne, G, Varshney, A, Corbin, LJ, Luan, J'an, Willems, SM, Wu, Y, Zhang, X, Horikoshi, M, Boutin, TS, Mägi, R, Waage, J, Li-Gao, R, Chan, KHang Katie, Yao, J, Anasanti, MD, Chu, AY, Claringbould, A, Heikkinen, J, Hong, J, Hottenga, J-J, Huo, S, Kaakinen, MA, Louie, T, Marz, W, Moreno-Macias, H, Ndungu, A, Nelson, SC, Nolte, IM, North, KE, Raulerson, CK, Ray, D, Rohde, R, Rybin, D, Schurmann, C, Sim, X, Southam, L, Stewart, ID, Wang, CA, Wang, Y, Wu, P, Zhang, W, Ahluwalia, TS, Appel, EVR, Bielak, LF, Brody, JA, Burtt, NP, Cabrera, CP, Cade, BE, Chai, JFang, Chai, X, Chang, L-C, Chen, C-H, Chen, BH, Chitrala, KNaidu, Chiu, Y-F, de Haan, HG, Delgado, GE, Demirkan, A, Duan, Q, Engmann, J, Fatumo, SA, Gayán, J, Giulianini, F, Gong, JHo, Gustafsson, S, Hai, Y, Hartwig, FP, He, J, Heianza, Y, Huang, T, Huerta-Chagoya, A, Hwang, MYeong, Jensen, RA, Kawaguchi, T, Kentistou, KA, Kim, YJin, Kleber, ME, Kooner, IK, Lai, S, Lange, LA, Langefeld, CD, Lauzon, M, Li, M, Ligthart, S, Liu, J, Loh, M, Long, J, Lyssenko, V, Mangino, M, Marzi, C, Montasser, ME, Nag, A, Nakatochi, M, Noce, D, Noordam, R, Pistis, G, Preuss, M, Raffield, L, Rasmussen-Torvik, LJ, Rich, SS, Robertson, NR, Rueedi, R, Ryan, K, Sanna, S, Saxena, R, Schraut, KE, Sennblad, B, Setoh, K, Smith, AV, Sparsø, T, Strawbridge, RJ, Takeuchi, F, Tan, J, Trompet, S, van den Akker, E, van der Most, PJ, Verweij, N, Vogel, M, Wang, H, Wang, C, Wang, N, Warren, HR, Wen, W, Wilsgaard, T, Wong, A, Wood, AR, Xie, T, Zafarmand, MHadi, Zhao, J-H, Zhao, W, Amin, N, Arzumanyan, Z, Astrup, A, Bakker, SJL, Baldassarre, D, Beekman, M, Bergman, RN, Bertoni, A, Blüher, M, Bonnycastle, LL, Bornstein, SR, Bowden, DW, Cai, Q, Campbell, A, Campbell, H, Chang, YCheng, de Geus, EJC, Dehghan, A, Du, S, Eiriksdottir, G, Farmaki, AEleni, Frånberg, M, Fuchsberger, C, Gao, Y, Gjesing, AP, Goel, A, Han, S, Hartman, CA, Herder, C, Hicks, AA, Hsieh, C-H, Hsueh, WA, Ichihara, S, Igase, M, M Ikram, A, W Johnson, C, Jørgensen, ME, Joshi, PK, Kalyani, RR, Kandeel, FR, Katsuya, T, Khor, CChuen, Kiess, W, Kolcic, I, Kuulasmaa, T, Kuusisto, J, Läll, K, Lam, K, Lawlor, DA, Lee, NR, Lemaitre, RN, Li, H, Lin, S-Y, Lindström, J, Linneberg, A, Liu, J, Lorenzo, C, Matsubara, T, Matsuda, F, Mingrone, G, Mooijaart, S, Moon, S, Nabika, T, Nadkarni, GN, Nadler, JL, Nelis, M, Neville, MJ, Norris, JM, Ohyagi, Y, Peters, A, Peyser, PA, Polasek, O, Qi, Q, Raven, D, Reilly, DF, Reiner, A, Rivideneira, F, Roll, K, Rudan, I, Sabanayagam, C, Sandow, K, Sattar, N, Schürmann, A, Shi, J, Stringham, HM, Taylor, KD, Teslovich, TM, Thuesen, B, Timmers, PRHJ, Tremoli, E, Tsai, MY, Uitterlinden, A, van Dam, RM, van Heemst, D, Vlieg, Avan Hylcka, Van Vliet-Ostaptchouk, JV, Vangipurapu, J, Vestergaard, H, Wang, T, van Dijk, KWillems, Zemunik, T, Abecasis, GR, Adair, LS, Aguilar-Salinas, CAlberto, Alarcón-Riquelme, ME, An, P, Aviles-Santa, L, Becker, DM, Beilin, LJ, Bergmann, S, Bisgaard, H, Black, C, Boehnke, M, Boerwinkle, E, Böhm, BO, Bønnelykke, K, Boomsma, DI, Bottinger, EP, Buchanan, TA, Canouil, M, Caulfield, MJ, Chambers, JC, Chasman, DI, Chen, Y-DIda, Cheng, C-Y, Collins, FS, Correa, A, Cucca, F, H de Silva, J, Dedoussis, G, Elmståhl, S, Evans, MK, Ferrannini, E, Ferrucci, L, Florez, JC, Franks, PW, Frayling, TM, Froguel, P, Gigante, B, Goodarzi, MO, Gordon-Larsen, P, Grallert, H, Grarup, N, Grimsgaard, S, Groop, L, Gudnason, V, Guo, X, Hamsten, A, Hansen, T, Hayward, C, Heckbert, SR, Horta, BL, Huang, W, Ingelsson, E, James, PS, Jarvelin, M-R, Jonas, JB, J Jukema, W, Kaleebu, P, Kaplan, R, Kardia, SLR, Kato, N, Keinanen-Kiukaanniemi, SM, Kim, B-J, Kivimaki, M, Koistinen, HA, Kooner, JS, Körner, A, Kovacs, P, Kuh, D, Kumari, M, Kutalik, Z, Laakso, M, Lakka, TA, Launer, LJ, Leander, K, Li, H, Lin, X, Lind, L, Lindgren, C, Liu, S, Loos, RJF, Magnusson, PKE, Mahajan, A, Metspalu, A, Mook-Kanamori, DO, Mori, TA, Munroe, PB, Njølstad, I, O'Connell, JR, Oldehinkel, AJ, Ong, KK, Padmanabhan, S, Palmer, CNA, Palmer, ND, Pedersen, O, Pennell, CE, Porteous, DJ, Pramstaller, PP, Province, MA, Psaty, BM, Qi, L, Raffel, LJ, Rauramaa, R, Redline, S, Ridker, PM, Rosendaal, FR, Saaristo, TE, Sandhu, M, Saramies, J, Schneiderman, N, Schwarz, P, Scott, LJ, Selvin, E, Sever, P, Shu, X-O, P Slagboom, E, Small, KS, Smith, BH, Snieder, H, Sofer, T, Sørensen, TIA, Spector, TD, Stanton, A, Steves, CJ, Stumvoll, M, Sun, L, Tabara, Y, E Tai, S, Timpson, NJ, Tonjes, A, Tuomilehto, J, Tusie, T, Uusitupa, M, van der Harst, P, van Duijn, C, Vitart, V, Vollenweider, P, Vrijkotte, TGM, Wagenknecht, LE, Walker, M, Wang, YX, Wareham, NJ, Watanabe, RM, Watkins, H, Wei, WB, Wickremasinghe, AR, Willemsen, G, Wilson, JF, Wong, T-Y, Wu, J-Y, Xiang, AH, Yanek, LR, Yengo, L, Yokota, M, Zeggini, E, Zheng, W, Zonderman, AB, Rotter, JI, Gloyn, AL, McCarthy, MI, Dupuis, J, Meigs, JB, Scott, RA, Prokopenko, I, Leong, A, Liu, C-T, Parker, SCJ, Mohlke, KL, Langenberg, C, Wheeler, E, Morris, AP, Barroso, I
Corporate AuthorsLifeLines Cohort Study, Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC)
JournalNat Genet
Volume53
Issue6
Pagination840-860
Date Published2021 Jun
ISSN1546-1718
KeywordsAlleles, Blood Glucose, Epigenesis, Genetic, Gene Expression Profiling, Genome, Human, Genome-Wide Association Study, Glycated Hemoglobin, Humans, Multifactorial Inheritance, Physical Chromosome Mapping, Quantitative Trait Loci, Quantitative Trait, Heritable, White People
Abstract

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P 

DOI10.1038/s41588-021-00852-9
Alternate JournalNat Genet
PubMed ID34059833
PubMed Central IDPMC7610958
Grant ListD43 TW009077 / TW / FIC NIH HHS / United States
R01 DK093757 / DK / NIDDK NIH HHS / United States
U24 MH068457 / MH / NIMH NIH HHS / United States
RP-PG-0407-10371 / DH_ / Department of Health / United Kingdom
MC_UU_00006/1 / MRC_ / Medical Research Council / United Kingdom
K013351 / MRC_ / Medical Research Council / United Kingdom
G0601966 / MRC_ / Medical Research Council / United Kingdom
CZB/4/710 / CSO_ / Chief Scientist Office / United Kingdom
N01HC85080 / HL / NHLBI NIH HHS / United States
MC_UU_12019/1 / MRC_ / Medical Research Council / United Kingdom
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G952010 / MRC_ / Medical Research Council / United Kingdom
UM1 CA173640 / CA / NCI NIH HHS / United States
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MC_PC_U127592696 / MRC_ / Medical Research Council / United Kingdom
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PG/11/63/29011 / BHF_ / British Heart Foundation / United Kingdom
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