The trans-ancestral genomic architecture of glycemic traits.

TitleThe trans-ancestral genomic architecture of glycemic traits.
Publication TypeJournal Article
Year of Publication2021
AuthorsChen, J, Spracklen, CN, Marenne, G, Varshney, A, Corbin, LJ, Luan, J'an, Willems, SM, Wu, Y, Zhang, X, Horikoshi, M, Boutin, TS, Mägi, R, Waage, J, Li-Gao, R, Chan, KHang Katie, Yao, J, Anasanti, MD, Chu, AY, Claringbould, A, Heikkinen, J, Hong, J, Hottenga, J-J, Huo, S, Kaakinen, MA, Louie, T, Marz, W, Moreno-Macias, H, Ndungu, A, Nelson, SC, Nolte, IM, North, KE, Raulerson, CK, Ray, D, Rohde, R, Rybin, D, Schurmann, C, Sim, X, Southam, L, Stewart, ID, Wang, CA, Wang, Y, Wu, P, Zhang, W, Ahluwalia, TS, Appel, EVR, Bielak, LF, Brody, JA, Burtt, NP, Cabrera, CP, Cade, BE, Chai, JFang, Chai, X, Chang, L-C, Chen, C-H, Chen, BH, Chitrala, KNaidu, Chiu, Y-F, de Haan, HG, Delgado, GE, Demirkan, A, Duan, Q, Engmann, J, Fatumo, SA, Gayán, J, Giulianini, F, Gong, JHo, Gustafsson, S, Hai, Y, Hartwig, FP, He, J, Heianza, Y, Huang, T, Huerta-Chagoya, A, Hwang, MYeong, Jensen, RA, Kawaguchi, T, Kentistou, KA, Kim, YJin, Kleber, ME, Kooner, IK, Lai, S, Lange, LA, Langefeld, CD, Lauzon, M, Li, M, Ligthart, S, Liu, J, Loh, M, Long, J, Lyssenko, V, Mangino, M, Marzi, C, Montasser, ME, Nag, A, Nakatochi, M, Noce, D, Noordam, R, Pistis, G, Preuss, M, Raffield, L, Rasmussen-Torvik, LJ, Rich, SS, Robertson, NR, Rueedi, R, Ryan, K, Sanna, S, Saxena, R, Schraut, KE, Sennblad, B, Setoh, K, Smith, AV, Sparsø, T, Strawbridge, RJ, Takeuchi, F, Tan, J, Trompet, S, van den Akker, E, van der Most, PJ, Verweij, N, Vogel, M, Wang, H, Wang, C, Wang, N, Warren, HR, Wen, W, Wilsgaard, T, Wong, A, Wood, AR, Xie, T, Zafarmand, MHadi, Zhao, J-H, Zhao, W, Amin, N, Arzumanyan, Z, Astrup, A, Bakker, SJL, Baldassarre, D, Beekman, M, Bergman, RN, Bertoni, A, Blüher, M, Bonnycastle, LL, Bornstein, SR, Bowden, DW, Cai, Q, Campbell, A, Campbell, H, Chang, YCheng, de Geus, EJC, Dehghan, A, Du, S, Eiriksdottir, G, Farmaki, AEleni, Frånberg, M, Fuchsberger, C, Gao, Y, Gjesing, AP, Goel, A, Han, S, Hartman, CA, Herder, C, Hicks, AA, Hsieh, C-H, Hsueh, WA, Ichihara, S, Igase, M, M Ikram, A, W Johnson, C, Jørgensen, ME, Joshi, PK, Kalyani, RR, Kandeel, FR, Katsuya, T, Khor, CChuen, Kiess, W, Kolcic, I, Kuulasmaa, T, Kuusisto, J, Läll, K, Lam, K, Lawlor, DA, Lee, NR, Lemaitre, RN, Li, H, Lin, S-Y, Lindström, J, Linneberg, A, Liu, J, Lorenzo, C, Matsubara, T, Matsuda, F, Mingrone, G, Mooijaart, S, Moon, S, Nabika, T, Nadkarni, GN, Nadler, JL, Nelis, M, Neville, MJ, Norris, JM, Ohyagi, Y, Peters, A, Peyser, PA, Polasek, O, Qi, Q, Raven, D, Reilly, DF, Reiner, A, Rivideneira, F, Roll, K, Rudan, I, Sabanayagam, C, Sandow, K, Sattar, N, Schürmann, A, Shi, J, Stringham, HM, Taylor, KD, Teslovich, TM, Thuesen, B, Timmers, PRHJ, Tremoli, E, Tsai, MY, Uitterlinden, A, van Dam, RM, van Heemst, D, Vlieg, Avan Hylcka, Van Vliet-Ostaptchouk, JV, Vangipurapu, J, Vestergaard, H, Wang, T, van Dijk, KWillems, Zemunik, T, Abecasis, GR, Adair, LS, Aguilar-Salinas, CAlberto, Alarcón-Riquelme, ME, An, P, Aviles-Santa, L, Becker, DM, Beilin, LJ, Bergmann, S, Bisgaard, H, Black, C, Boehnke, M, Boerwinkle, E, Böhm, BO, Bønnelykke, K, Boomsma, DI, Bottinger, EP, Buchanan, TA, Canouil, M, Caulfield, MJ, Chambers, JC, Chasman, DI, Chen, Y-DIda, Cheng, C-Y, Collins, FS, Correa, A, Cucca, F, H de Silva, J, Dedoussis, G, Elmståhl, S, Evans, MK, Ferrannini, E, Ferrucci, L, Florez, JC, Franks, PW, Frayling, TM, Froguel, P, Gigante, B, Goodarzi, MO, Gordon-Larsen, P, Grallert, H, Grarup, N, Grimsgaard, S, Groop, L, Gudnason, V, Guo, X, Hamsten, A, Hansen, T, Hayward, C, Heckbert, SR, Horta, BL, Huang, W, Ingelsson, E, James, PS, Jarvelin, M-R, Jonas, JB, J Jukema, W, Kaleebu, P, Kaplan, R, Kardia, SLR, Kato, N, Keinanen-Kiukaanniemi, SM, Kim, B-J, Kivimaki, M, Koistinen, HA, Kooner, JS, Körner, A, Kovacs, P, Kuh, D, Kumari, M, Kutalik, Z, Laakso, M, Lakka, TA, Launer, LJ, Leander, K, Li, H, Lin, X, Lind, L, Lindgren, C, Liu, S, Loos, RJF, Magnusson, PKE, Mahajan, A, Metspalu, A, Mook-Kanamori, DO, Mori, TA, Munroe, PB, Njølstad, I, O'Connell, JR, Oldehinkel, AJ, Ong, KK, Padmanabhan, S, Palmer, CNA, Palmer, ND, Pedersen, O, Pennell, CE, Porteous, DJ, Pramstaller, PP, Province, MA, Psaty, BM, Qi, L, Raffel, LJ, Rauramaa, R, Redline, S, Ridker, PM, Rosendaal, FR, Saaristo, TE, Sandhu, M, Saramies, J, Schneiderman, N, Schwarz, P, Scott, LJ, Selvin, E, Sever, P, Shu, X-O, P Slagboom, E, Small, KS, Smith, BH, Snieder, H, Sofer, T, Sørensen, TIA, Spector, TD, Stanton, A, Steves, CJ, Stumvoll, M, Sun, L, Tabara, Y, E Tai, S, Timpson, NJ, Tonjes, A, Tuomilehto, J, Tusie, T, Uusitupa, M, van der Harst, P, van Duijn, C, Vitart, V, Vollenweider, P, Vrijkotte, TGM, Wagenknecht, LE, Walker, M, Wang, YX, Wareham, NJ, Watanabe, RM, Watkins, H, Wei, WB, Wickremasinghe, AR, Willemsen, G, Wilson, JF, Wong, T-Y, Wu, J-Y, Xiang, AH, Yanek, LR, Yengo, L, Yokota, M, Zeggini, E, Zheng, W, Zonderman, AB, Rotter, JI, Gloyn, AL, McCarthy, MI, Dupuis, J, Meigs, JB, Scott, RA, Prokopenko, I, Leong, A, Liu, C-T, Parker, SCJ, Mohlke, KL, Langenberg, C, Wheeler, E, Morris, AP, Barroso, I
Corporate AuthorsLifeLines Cohort Study, Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC)
JournalNat Genet
Date Published2021 May 31
ISSN1546-1718
Abstract

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P 

DOI10.1038/s41588-021-00852-9
Alternate JournalNat Genet
PubMed ID34059833