Unique features of a global human ectoparasite identified through sequencing of the bed bug genome.

TitleUnique features of a global human ectoparasite identified through sequencing of the bed bug genome.
Publication TypeJournal Article
Year of Publication2016
AuthorsBenoit, JB, Adelman, ZN, Reinhardt, K, Dolan, A, Poelchau, M, Jennings, EC, Szuter, EM, Hagan, RW, Gujar, H, Shukla, JNath, Zhu, F, Mohan, M, Nelson, DR, Rosendale, AJ, Derst, C, Resnik, V, Wernig, S, Menegazzi, P, Wegener, C, Peschel, N, Hendershot, JM, Blenau, W, Predel, R, Johnston, PR, Ioannidis, P, Waterhouse, RM, Nauen, R, Schorn, C, Ott, M-C, Maiwald, F, J Johnston, S, Gondhalekar, AD, Scharf, ME, Peterson, BF, Raje, KR, Hottel, BA, Armisén, D, Crumière, AJean Johan, Refki, PNagui, Santos, MEmilia, Sghaier, E, Viala, S, Khila, A, Ahn, S-J, Childers, C, Lee, C-Y, Lin, H, Hughes, DST, Duncan, EJ, Murali, SC, Qu, J, Dugan, S, Lee, SL, Chao, H, Dinh, H, Han, Y, Doddapaneni, HV, Worley, KC, Muzny, DM, Wheeler, DA, Panfilio, KA, Jentzsch, IMVargas, Vargo, EL, Booth, W, Friedrich, M, Weirauch, MT, Anderson, MAE, Jones, JW, Mittapalli, O, Zhao, C, Zhou, J-J, Evans, JD, Attardo, GM, Robertson, HM, Zdobnov, EM, Ribeiro, JMC, Gibbs, RA, Werren, JH, Palli, SR, Schal, C, Richards, S
JournalNat Commun
Volume7
Pagination10165
Date Published2016 Feb 02
ISSN2041-1723
KeywordsAnimals, Bedbugs, Ectoparasitic Infestations, Feeding Behavior, Gene Transfer, Horizontal, Genome, Host-Parasite Interactions, Humans, Insecticide Resistance, Insecticides, Sequence Analysis, DNA
Abstract

The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host-symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human-bed bug and symbiont-bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite.

DOI10.1038/ncomms10165
Alternate JournalNat Commun
PubMed ID26836814
PubMed Central IDPMC4740739
Grant ListGM070559-9 / GM / NIGMS NIH HHS / United States
R01 GM070559 / GM / NIGMS NIH HHS / United States
U54 HG003273 / HG / NHGRI NIH HHS / United States
ERC_260986 / / European Research Council / International
ERC_616346 / / European Research Council / International