Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.

 
TitleUnraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.
Publication TypeJournal Article
Year of Publication2019
AuthorsYee, SWah, Stecula, A, Chien, H-C, Zou, L, Feofanova, EV, van Borselen, M, Cheung, KWun Kathy, Yousri, NA, Suhre, K, Kinchen, JM, Boerwinkle, E, Irannejad, R, Yu, B, Giacomini, KM
JournalPLoS Genet
Volume15
Issue9
Paginatione1008208
Date Published2019 Sep
ISSN1553-7404
Abstract

Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects. Beginning with metabolomic data from genome-wide association studies (GWAS), we observed that genetic variants in the orphan transporter, SLC22A24 were significantly associated with levels of androsterone glucuronide and etiocholanolone glucuronide (sentinel SNPs p-value

DOI10.1371/journal.pgen.1008208
Alternate JournalPLoS Genet.
PubMed ID31553721