Variation in predicted COVID-19 risk among lemurs and lorises.

TitleVariation in predicted COVID-19 risk among lemurs and lorises.
Publication TypeJournal Article
Year of Publication2021
AuthorsMelin, AD, Orkin, JD, Janiak, MC, Valenzuela, A, Kuderna, L, Marrone, F, Ramangason, H, Horvath, JE, Roos, C, Kitchener, AC, Khor, CChuen, Lim, WKhong, Lee, JGH, Tan, P, Umapathy, G, Raveendran, M, Harris, RA, Gut, I, Gut, M, Lizano, E, Nadler, T, Zinner, D, Le, MD, Manu, S, Rabarivola, CJ, Zaramody, A, Andriaholinirina, N, Johnson, SE, Jarvis, ED, Fedrigo, O, Wu, D, Zhang, G, Farh, KKai-How, Rogers, J, Marques-Bonet, T, Navarro, A, Juan, D, Arora, PS, Higham, JP
JournalAm J Primatol
Paginatione23255
Date Published2021 Apr 01
ISSN1098-2345
Abstract

The novel coronavirus SARS-CoV-2, which in humans leads to the disease COVID-19, has caused global disruption and more than 2 million fatalities since it first emerged in late 2019. As we write, infection rates are at their highest point globally and are rising extremely rapidly in some areas due to more infectious variants. The primary target of SARS-CoV-2 is the cellular receptor angiotensin-converting enzyme-2 (ACE2). Recent sequence analyses of the ACE2 gene predict that many nonhuman primates are also likely to be highly susceptible to infection. However, the anticipated risk is not equal across the Order. Furthermore, some taxonomic groups show high ACE2 amino acid conservation, while others exhibit high variability at this locus. As an example of the latter, analyses of strepsirrhine primate ACE2 sequences to date indicate large variation among lemurs and lorises compared to other primate clades despite low sampling effort. Here, we report ACE2 gene and protein sequences for 71 individual strepsirrhines, spanning 51 species and 19 genera. Our study reinforces previous results while finding additional variability in other strepsirrhine species, and suggests several clades of lemurs have high potential susceptibility to SARS-CoV-2 infection. Troublingly, some species, including the rare and endangered aye-aye (Daubentonia madagascariensis), as well as those in the genera Avahi and Propithecus, may be at high risk. Given that lemurs are endemic to Madagascar and among the primates at highest risk of extinction globally, further understanding of the potential threat of COVID-19 to their health should be a conservation priority. All feasible actions should be taken to limit their exposure to SARS-CoV-2.

DOI10.1002/ajp.23255
Alternate JournalAm J Primatol
PubMed ID33792947
Grant ListGRC 2017 SGR 880 / / CERCA Programme del Departament d'Economia i Coneixement de la Generalitat de Catalunya /
/ / Secretaria d'Universitats i Recerca /
/ / Spanish Ministry of Science and Innovation - Instituto de Salud Carlos III /
/ / Rockefeller University /
/ / Centro de Excelencia Severo Ochoa /
/ / Natural Sciences and Engineering Research Council of Canada (NSERC Discovery Grant) /
/ / Generalitat de Catalunya (Departament de Salut, Departament d'Empresa i Coneixement) /
R35GM130333 / NH / NIH HHS / United States
BFU2017-86471-P (MINECO/FEDER / / CERCA /
UE) / / CERCA /
864203 / / European Research Council (ERC) - European Union's Horizon 2020 research and innovation programme /
/ / Smart Growth Operating Program (2014-2020) /
CGL2017-82654-P / / MINECO/FEDER, UE /
AEI (CEX2018-000792-M) / / Unidad de Excelencia María de Maeztu /
/ / Canada Research Chairs Program /
MINECO/FEDER / / European Regional Development Fund /
BIO2015-71792-P / / European Regional Development Fund /
/ HHMI / Howard Hughes Medical Institute / United States
/ / Obra Social "La Caixa" /
NERC NE/T000341/1 / / Natural Environment Research Council /
/ / Howard Hughes International Early Career /