What everybody should know about the rat genome and its online resources.

TitleWhat everybody should know about the rat genome and its online resources.
Publication TypeJournal Article
Year of Publication2008
AuthorsTwigger, SN, Pruitt, KD, Fernandez-Suarez, XM, Karolchik, D, Worley, KC, Maglott, DR, Brown, G, Weinstock, G, Gibbs, RA, Kent, J, Birney, E, Jacob, HJ
JournalNat Genet
Volume40
Issue5
Pagination523-7
Date Published2008 May
ISSN1546-1718
KeywordsAnimals, Computational Biology, Databases, Genetic, Disease Models, Animal, Genetic Diseases, Inborn, Genetic Variation, Genome, Genomics, Haplotypes, Humans, Internet, Polymorphism, Single Nucleotide, Rats, Rats, Mutant Strains, Sequence Analysis, DNA
Abstract

It has been four years since the original publication of the draft sequence of the rat genome. Five groups are now working together to assemble, annotate and release an updated version of the rat genome. As the prevailing model for physiology, complex disease and pharmacological studies, there is an acute need for the rat's genomic resources to keep pace with the rat's prominence in the laboratory. In this commentary, we describe the current status of the rat genome sequence and the plans for its impending 'upgrade'. We then cover the key online resources providing access to the rat genome, including the new SNP views at Ensembl, the RefSeq and Genes databases at the US National Center for Biotechnology Information, Genome Browser at the University of California Santa Cruz and the disease portals for cardiovascular disease and obesity at the Rat Genome Database.

DOI10.1038/ng0508-523
Alternate JournalNat. Genet.
PubMed ID18443589
PubMed Central IDPMC2505193
Grant ListR01 HL064541 / HL / NHLBI NIH HHS / United States
Z99 LM999999 / / Intramural NIH HHS / United States
U41 HG002273 / HG / NHGRI NIH HHS / United States
HL-64541 / HL / NHLBI NIH HHS / United States
U54 HG003273 / HG / NHGRI NIH HHS / United States
HG-002273 / HG / NHGRI NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
R01 HG002273 / HG / NHGRI NIH HHS / United States
HG-003273 / HG / NHGRI NIH HHS / United States
P41 HG002273 / HG / NHGRI NIH HHS / United States