Whole-genome sequencing study of serum peptide levels: the Atherosclerosis Risk in Communities study.

TitleWhole-genome sequencing study of serum peptide levels: the Atherosclerosis Risk in Communities study.
Publication TypeJournal Article
Year of Publication2017
Authorsde Vries, PS, Yu, B, Feofanova, EV, Metcalf, GA, Brown, MR, Zeighami, AL, Liu, X, Muzny, DM, Gibbs, RA, Boerwinkle, E, Morrison, AC
JournalHum Mol Genet
Volume26
Issue17
Pagination3442-3450
Date Published2017 Sep 01
ISSN1460-2083
Abstract

Oligopeptides are important markers of protein metabolism, as they are cleaved from larger polypeptides and proteins. Genetic association studies may help elucidate their origin and function. In 1,552 European Americans and 1,872 African Americans of the Atherosclerosis Risk in Communities study, we performed whole-genome and whole-exome sequencing and measured serum levels of 25 peptides. Common variants (minor allele frequency > 5%) were analysed individually. We grouped low-frequency variants (minor allele frequency ≤ 5%) by a genome-wide sliding window using region-based aggregate tests. Furthermore, low-frequency regulatory variants were grouped by gene, as were functional coding variants. All analyses were performed separately in each ancestry group and then meta-analysed. We identified 22 common variant associations with peptide levels (P-value 

DOI10.1093/hmg/ddx266
Alternate JournalHum. Mol. Genet.
PubMed ID28854705