WormBase: a multi-species resource for nematode biology and genomics.

TitleWormBase: a multi-species resource for nematode biology and genomics.
Publication TypeJournal Article
Year of Publication2004
AuthorsHarris, TW, Chen, N, Cunningham, F, Tello-Ruiz, M, Antoshechkin, I, Bastiani, C, Bieri, T, Blasiar, D, Bradnam, K, Chan, J, Chen, C-K, Chen, WJ, Davis, P, Kenny, E, Kishore, R, Lawson, D, Lee, R, Muller, H-M, Nakamura, C, Ozersky, P, Petcherski, A, Rogers, A, Sabo, A, Schwarz, EM, Van Auken, K, Wang, Q, Durbin, R, Spieth, J, Sternberg, PW, Stein, LD
JournalNucleic Acids Res
Volume32
IssueDatabase issue
PaginationD411-7
Date Published2004 Jan 01
ISSN1362-4962
KeywordsAnimals, Caenorhabditis, Caenorhabditis elegans, Computational Biology, Databases, Genetic, Genomics, Information Storage and Retrieval, Internet, User-Computer Interface
Abstract

WormBase (http://www.wormbase.org/) is the central data repository for information about Caenorhabditis elegans and related nematodes. As a model organism database, WormBase extends beyond the genomic sequence, integrating experimental results with extensively annotated views of the genome. The WormBase Consortium continues to expand the biological scope and utility of WormBase with the inclusion of large-scale genomic analyses, through active data and literature curation, through new analysis and visualization tools, and through refinement of the user interface. Over the past year, the nearly complete genomic sequence and comparative analyses of the closely related species Caenorhabditis briggsae have been integrated into WormBase, including gene predictions, ortholog assignments and a new synteny viewer to display the relationships between the two species. Extensive site-wide refinement of the user interface now provides quick access to the most frequently accessed resources and a consistent browsing experience across the site. Unified single-page views now provide complete summaries of commonly accessed entries like genes. These advances continue to increase the utility of WormBase for C.elegans researchers, as well as for those researchers exploring problems in functional and comparative genomics in the context of a powerful genetic system.

DOI10.1093/nar/gkh066
Alternate JournalNucleic Acids Res.
PubMed ID14681445
PubMed Central IDPMC308800
Grant ListP41 HG002223 / HG / NHGRI NIH HHS / United States
P41-HG02223 / HG / NHGRI NIH HHS / United States