X-linked genetic associations in sporadic thoracic aortic dissection.

TitleX-linked genetic associations in sporadic thoracic aortic dissection.
Publication TypeJournal Article
Year of Publication2024
AuthorsMusfee, FI, Jun, G, Mitchell, LE, Chen, H, Guo, D, Prakash, SK, Adkar, SSanjay, Grove, ML, Choi, RBohyun, Klarin, D, Boerwinkle, E, Milewicz, DM
Corporate AuthorsMillion Veteran Program
JournalAm J Med Genet A
Paginatione63644
Date Published2024 Apr 30
ISSN1552-4833
Abstract

The male predominance in sporadic thoracic aortic aneurysm and dissection (TAD) suggests that the X chromosome contributes to TAD, but this has not been tested. We investigated whether X-linked variation-common (minor allele frequency [MAF] ≥0.01) and rare (MAF

DOI10.1002/ajmg.a.63644
Alternate JournalAm J Med Genet A
PubMed ID38688863
Grant List / NH / NIH HHS / United States