X-linked genetic associations in sporadic thoracic aortic dissection.

TitleX-linked genetic associations in sporadic thoracic aortic dissection.
Publication TypeJournal Article
Year of Publication2024
AuthorsMusfee, FI, Jun, G, Mitchell, LE, Chen, H, Guo, D, Prakash, SK, Adkar, SSanjay, Grove, ML, Choi, RBohyun, Klarin, D, Boerwinkle, E, Milewicz, DM
Corporate AuthorsMillion Veteran Program
JournalAm J Med Genet A
Volume194
Issue9
Paginatione63644
Date Published2024 Sep
ISSN1552-4833
KeywordsAged, Aortic Aneurysm, Thoracic, Case-Control Studies, Chromosomes, Human, X, Cohort Studies, Dissection, Thoracic Aorta, Female, Gene Frequency, Genes, X-Linked, Genetic Association Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide
Abstract

The male predominance in sporadic thoracic aortic aneurysm and dissection (TAD) suggests that the X chromosome contributes to TAD, but this has not been tested. We investigated whether X-linked variation-common (minor allele frequency [MAF] ≥0.01) and rare (MAF

DOI10.1002/ajmg.a.63644
Alternate JournalAm J Med Genet A
PubMed ID38688863
PubMed Central IDPMC11315632
Grant ListRC2 HL102419 / HL / NHLBI NIH HHS / United States
/ / Baszucki Research Initiative /
R01 HL062594 / HL / NHLBI NIH HHS / United States
/ / American Heart Association /
R01 DK118631 / DK / NIDDK NIH HHS / United States
HHSN268201700002C / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
R03 HD098552 / HD / NICHD NIH HHS / United States
HHSN268201700004C / HL / NHLBI NIH HHS / United States
P50 HL083794 / HL / NHLBI NIH HHS / United States
R01 HL109942 / HL / NHLBI NIH HHS / United States
IK2 BX005759 / BX / BLRD VA / United States
/ / U.S. Department of Veterans Affairs /
HHSN268201700005C / HL / NHLBI NIH HHS / United States
HHSN268201700003C / HL / NHLBI NIH HHS / United States
/ NH / NIH HHS / United States
HHSN268201700001C / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
P01 HL110869 / HL / NHLBI NIH HHS / United States

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