Zoonotic Potential of Simian Arteriviruses.

TitleZoonotic Potential of Simian Arteriviruses.
Publication TypeJournal Article
Year of Publication2015
AuthorsBailey, AL, Lauck, M, Sibley, SD, Friedrich, TC, Kuhn, JH, Freimer, NB, Jasinska, AJ, Phillips-Conroy, JE, Jolly, CJ, Marx, PA, Apetrei, C, Rogers, J, Goldberg, TL, O'Connor, DH
JournalJ Virol
Date Published2015 Nov 11
KeywordsAnimals, Arterivirus, Arterivirus Infections, Haplorhini, Humans, Primate Diseases, Zoonoses

Wild nonhuman primates are immediate sources and long-term reservoirs of human pathogens. However, ethical and technical challenges have hampered the identification of novel blood-borne pathogens in these animals. We recently examined RNA viruses in plasma from wild African monkeys and discovered several novel, highly divergent viruses belonging to the family Arteriviridae. Close relatives of these viruses, including simian hemorrhagic fever virus, have caused sporadic outbreaks of viral hemorrhagic fever in captive macaque monkeys since the 1960s. However, arterivirus infection in wild nonhuman primates had not been described prior to 2011. The arteriviruses recently identified in wild monkeys have high sequence and host species diversity, maintain high viremia, and are prevalent in affected populations. Taken together, these features suggest that the simian arteriviruses may be "preemergent" zoonotic pathogens. If not, this would imply that biological characteristics of RNA viruses thought to facilitate zoonotic transmission may not, by themselves, be sufficient for such transmission to occur.

Alternate JournalJ. Virol.
PubMed ID26559828
PubMed Central IDPMC4702702
Grant ListRR15459-01 / RR / NCRR NIH HHS / United States
RR020141-01 / RR / NCRR NIH HHS / United States
R01OD010980 / OD / NIH HHS / United States
P51RR000167 / RR / NCRR NIH HHS / United States
T32 GM008692 / GM / NIGMS NIH HHS / United States
P51 OD011104 / OD / NIH HHS / United States
TW009237 / TW / FIC NIH HHS / United States
R01RR016300 / RR / NCRR NIH HHS / United States
R01AI084787 / AI / NIAID NIH HHS / United States
HHSN272200700016I / / PHS HHS / United States
R01 AI116382 / AI / NIAID NIH HHS / United States
R01RR025781 / RR / NCRR NIH HHS / United States
P01AI088564 / AI / NIAID NIH HHS / United States
R01AI077376-01 / AI / NIAID NIH HHS / United States
T32 AI55397 / AI / NIAID NIH HHS / United States

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