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Pancreaticobiliary and Duodenal Tumors

Image: adenocarcinoma of Pancreas
Image source: Ed Uthman from Houston, TX, USA (Adenocarcinoma of Pancreas, FNAUploaded by CFCF) [CC-BY-2.0], via Wikimedia Commons

Profiling the genome of the pancreaticobiliary and duodenal tumors

The pancreas is the site of different tumor types originating from different cellular components. The pancreas is connected to the surrounding organs by the pancreatic duct that is fused with the bile duct to form the Ampulla of Vater in the duodenal region. It is a complex environment from which arises some of the deadliest tumors such as the pancreatic ductal adenocarcinoma (PDAC), the 11th most common cancer in the USA but the 4th in fatalities.

The onset and progression of cancer is driven by extensive rearrangement and mutation of the genome. My interest is to detect and characterize the somatic mutation profile of PDAC, pancreatic neuroendocrine tumor, precancerous IPMN, ampullary adenocarcinoma, cholangiocarcinoma, and ductal adenocarcinoma. By collaborating with local and international institutions to obtain representative amount of tumors and comparing the profile of each of these tumors, my collaborators and I are hoping to identify driver genes that can be targeted for personalized treatment.

Related Publications

Genomic profiling guides the choice of molecular targeted therapy of pancreatic cancer., Frank, Thomas S., Sun Xiaotian, Zhang Yuqing, Yang Jingxuan, Fisher William E., Gingras Marie-Claude, and Li Min , Cancer letters, 2015 Apr 15, (2015) Abstract
PDX-1 is a therapeutic target for pancreatic cancer, insulinoma and islet neoplasia using a novel RNA interference platform., Liu, Shi-He, Rao Donald D., Nemunaitis John, Senzer Neil, Zhou Guisheng, Dawson David, Gingras Marie-Claude, Wang Zhaohui, Gibbs Richard, Norman Michael, et al. , PloS one, 2012, Volume 7, Issue 8, p.e40452, (2012) Abstract
Genomic sequencing of key genes in mouse pancreatic cancer cells., Wang, Y., Zhang Y., Yang J., Ni X., Liu S., Li Z., Hodges S. E., Fisher W. E., Brunicardi F. C., Gibbs R. A., et al. , Current molecular medicine, 2012 Mar, Volume 12, Issue 3, p.331-41, (2012) Abstract
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes., Biankin, Andrew V., Waddell Nicola, Kassahn Karin S., Gingras Marie-Claude, Muthuswamy Lakshmi B., Johns Amber L., Miller David K., Wilson Peter J., Patch Ann-Marie, Wu Jianmin, et al. , Nature, 2012 Nov 15, Volume 491, Issue 7424, p.399-405, (2012) Abstract
The hypofunctional effect of P335L single nucleotide polymorphism on SSTR5 function., Zhou, Guisheng, Gingras Marie-Claude, Liu Shi-He, Li Donghui, Li Zhijun, Catania Robbi L., Stehling Kelly M., Li Min, Paganelli Giovanni, Gibbs Richard A., et al. , World journal of surgery, 2011 Aug, Volume 35, Issue 8, p.1715-24, (2011) Abstract
SSTR5 P335L monoclonal antibody differentiates pancreatic neuroendocrine neuroplasms with different SSTR5 genotypes., Zhou, Guisheng, Gingras Marie-Claude, Liu Shi-He, Sanchez Robbi, Edwards Dean, Dawson David, Christensen Kurt, Paganelli Giovanni, Gibbs Richard, Fisher William, et al. , Surgery, 2011 Dec, Volume 150, Issue 6, p.1136-42, (2011) Abstract
PDX-1: demonstration of oncogenic properties in pancreatic cancer., Liu, Shi-He, Patel Sanjeet, Gingras Marie-Claude, Nemunaitis John, Zhou Guisheng, Chen Changyi, Li Min, Fisher William, Gibbs Richard, and Brunicardi Charles F. , Cancer, 2011 Feb 15, Volume 117, Issue 4, p.723-33, (2011) Abstract
Association between somatostatin receptor 5 gene polymorphisms and pancreatic cancer risk and survival., Li, Donghui, Tanaka Motofumi, Brunicardi Charles F., Fisher William E., Gibbs Richard A., and Gingras Marie-Claude , Cancer, 2011 Jul 1, Volume 117, Issue 13, p.2863-72, (2011) Abstract
Microarray analysis of somatostatin receptor 5-regulated gene expression profiles in murine pancreas., Patel, Sanjeet G., Zhou Guisheng, Liu Shi-He, Li Min, Jeong Jae-Wook, DeMayo Francesco J., Gingras Marie-Claude, Gibbs Richard A., Fisher William E., and Brunicardi Charles F. , World journal of surgery, 2009 Apr, Volume 33, Issue 4, p.630-7, (2009) Abstract
Developing a tissue resource to characterize the genome of pancreatic cancer., Voidonikolas, Georgios, Gingras Marie-Claude, Hodges Sally, McGuire Amy L., Chen Changyi, Gibbs Richard A., Brunicardi Charles F., and Fisher William E. , World journal of surgery, 2009 Apr, Volume 33, Issue 4, p.723-31, (2009) Abstract
Basic principles and technologies for deciphering the genetic map of cancer., Voidonikolas, Georgios, Kreml Stephanie S., Chen Changyi, Fisher William E., Brunicardi Charles F., Gibbs Richard A., and Gingras Marie-Claude , World journal of surgery, 2009 Apr, Volume 33, Issue 4, p.615-29, (2009) Abstract
Single nucleotide polymorphism in RECQL and survival in resectable pancreatic adenocarcinoma., Cotton, Ronald T., Li Donghui, Scherer Steven E., Muzny Donna M., Hodges Sally E., Catania Robbi L., Witkiewicz Agnieszka K., Brody Jonathan R., Kennedy Eugene P., Yeo Charles J., et al. , HPB : the official journal of the International Hepato Pancreato Biliary Association, 2009 Aug, Volume 11, Issue 5, p.435-44, (2009) Abstract
PDX-1 acts as a potential molecular target for treatment of human pancreatic cancer., Liu, Shihe, Ballian Nikiforos, Belaguli Narasimhaswamy S., Patel Sanjeet, Li Min, Templeton Nancy Smyth, Gingras Marie-Claude, Gibbs Richard, Fisher William, and Brunicardi Charles F. , Pancreas, 2008 Aug, Volume 37, Issue 2, p.210-20, (2008) Abstract
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