The Human Genome Sequencing Center (HGSC) at Baylor College of Medicine is now seeking an ACMG Board Certified Director of its HGSC-Clinical Laboratory (HGSC-CL) to oversee the finalization of HGSC-CL diagnostic reports and to develop research collaborations with partner institutions.
In 2016 the HGSC has opened a CAP/CLIA laboratory (called the HGSC-CL) with the mission of carrying out high-throughput clinical research sequencing programs. The HGSC-CL is currently heavily involved in the All of Us Research Program, and anticipates signing-out a high volume of health-related results reports, based on whole genome sequence data, over the coming years. This role offers ample opportunity to develop new research directions at the interface between research investigation and clinical care.
This position provides a unique opportunity to work on the cutting-edge of genomic science at the center of Houston's Texas Medical Center. With approximately 200 employees and occupying 36,000 square feet of BCM's Alkek Building, the HGSC boasts state-of-the-art sequencing and High Performance Computing technology. Over the next five years the HGSC will sequence more than 100,000 samples and manage close to 100 PB of data for both our research efforts and our clinical lab. The successful applicant will work with the entire HGSC including laboratory process development groups, high performance computing specialists and investigative biologists.
Baylor college of Medicine (BCM) is a health sciences university within the Texas Medical Center, Houston, Texas. BCM recently developed a relationship with the Baylor-Scott-White Research Institute in Dallas Texas, consolidating research and clinical care across the state. The Human Genome Sequencing Center (HGSC) at Baylor College of Medicine was founded in 1996 under the leadership of Dr. Richard Gibbs and is a world leader in genomics, having previously developed whole exome capture (WES) and collaboratively pioneered the first clinical exome laboratory. The primary mission of the HGSC is actionable translational research across the full spectrum of human health and disease using large-scale genomic data to drive collaborative analytics, gene-phenotype discovery and clinical innovation. The HGSC is funded from multiple National Institutes of Health sources, including the Center for Common Disease Genomics (CCDG) and the electronic Research in Medical Records (eMERGE) programs, funded by the National Human Genome Research Institute (NHGRI).
• Leads a team of variant interpretation specialists to review variants for clinical reporting.
• Plans and organizes the flow of samples through variant interpretation.
• Plans and reviews validations for new clinical testing efforts
• Finalizes ("signs-out") clinical reports prior to their release to clinical partners.
• May participate in the development of departmental grant budgets; the overseeing of expenditures of grant monies; performing accounting functions; producing expenditure reports.
• Interprets rules, regulations, and policies for faculty and laboratory staff and ensures compliance.
• May conduct laboratory research with principal investigators.
• Stays abreast of the latest guidance from ClinGen, ACMG, AMP and other expert groups to ensure the HGSC-CL remains on the cutting edge of genomic variant interpretation.
- Bachelor's degree in a Basic Science or a related field.
- Five years of relevant experience.
- An M.D. or PH.D. and Board Certification from the American College of Medical Genetics (ACMG).
- Relevant research experience and ambitions.
- Willingness to lead and oversee genetic diagnostics.
- Demonstrated experience in genetic counselling and delivery of genetic diagnostic data.
- Willingness to build collaborative relationships with a sister institution.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.