Medical Genetics Technologist II

Texas Medical Center, Houston, TX

The Baylor College of Medicine, Human Genome Sequencing Center-Clinical Laboratory (HGSC-CL) is recruiting for a Medical Genetics Tech II position. The HGSC-Clinical Laboratory is responsible for preparation of samples for NGS using capture methods in support of a number of high throughput clinical programs. The position would principally involve in NGS, library construction, hybrid capture methods, SNP array genotyping, and Sanger pipeline production in a CAP/CLIA environment. The candidate should be able to work independently and within a team to process samples in the production pipeline. Qualified candidates should be good at multi-tasking, problem-solving, and have strong communication skills. He/she should be flexible and adapt to the clinic environment and commit to finishing HGSC-CL goals in a timely manner.

  • Processing samples with robotics for lab procedures including library construction, and hybridization for Next Generation Sequencing (NGS).
  • PCR amplification and Sanger sequencing methods for variant validation.
  • Maintenance of instruments such as Covaris Sonicator, Beckman Robots, Agilent Bioanalyzer.
  • Sequencing on platforms such as Illumina HiSeq 2500, NovaSeq, and ABI 3730 instruments.
  • SNP array genotyping with Illumina and Fluidigm platforms.
  • Update LIMS, sample tracking and project summary using excel sheets.
  • Perform routine laboratory equipment maintenance and log records as required.
  • Collect, compile, evaluate and analyze data. Interpret detailed assay procedures and test results.
  • Troubleshoot problematic results for library construction, capture and sequencing methods.
  • Track the inventory for reagents and report to team lead when furthering order is needed.
  • Assist and train staff for production procedures.
  • Assist team lead in laboratory management.


  • Bachelor’s degree in Biology or related field.
  • One year of directly related experience.
  • Certification/registration as a Medical Technologist by The American Society of Clinical Pathologists (ASCP) or certification as a Clinical Lab Specialist in Genetics (NCA).

Preferred:  Molecular Biology skills including nucleic acid handling, enzymatic reaction, PCR reaction et. al. Sanger sequencing experience.