Postdoctoral Associate - Genomics

Vacancy number: 
Human Genome Sequencing Center
Salary range: 
Per NIH Guidelines
Texas Medical Center, Houston, TX


The Human Genome Sequencing Center (HGSC) at Baylor College of Medicine was founded in 1996 under the leadership of Dr. Richard Gibbs and is a world leader in genomics. The primary mission of the HGSC is actionable translational research across the full spectrum of human health and disease using large-scale genomic data to drive collaborative analytics, gene-phenotype discovery, and clinical innovation. The HGSC is funded from multiple National Institutes of Health sources, including the All of Us Research Program (AoURP) as a Genome Center, the Gregor Consortium to elucidate the genetics of rare disease funded by the National Human Genome Research Institute (NHGRI) and as a sequence technology core for the Texas Medical Center Genomic Center for Infectious Disease (GCID) established by the National Institute for Allergy and Infectious Diseases (NIAID). Being a premier large-scale sequencing center, the HGSC provides a unique opportunity to work on the cutting edge of genomic science in a state-of-the-art institution.

As part of a new National Institutes of Health Common Fund program called the Somatic Mosaicism across Human Tissues (SMaHT) Network, BCM-HGSC will establish a genome characterization center (GCC) for the consortium. The GCC will use existing state-of-the-art methodologies and tools as wells a develop new ones to catalog the extent of somatic mosaicism in different cell types, tissues and life stages, to better understand how much somatic mosaicism influences human biology and disease. The Baylor College of Medicine Human Genome Sequencing Center is seeking to recruit a Postdoctoral associate to work on SMaHT project and related activities.

Job Duties

  • Plans, directs and conducts specialized and advanced research experiments.
  • Establishes new laboratory research protocols and procedures. Evaluates different library and sequencing methodologies and analyzes data.
  • Tests, optimizes and scales up new DNA, RNA library and sequencing protocols.  
  • Summarizes research findings and publishes results in research journals. 
  • Conducts literature searches and summarizes information in an appropriate format for a particular study.
  • Reviews quality control checks on sequencing data, troubleshoots any technical issues, and ensures data integrity throughout the process.
  • Documents results of experiments and generate reports and present in internal and external meetings. 
  • Supervises, schedules, and coordinates the activities of less experienced research staff.

Minimum Qualifications

  • MD or Ph.D. in Basic Science, Health Science, or a related field.
  • No experience required.

Preferred Qualifications

  • Strong experience in new laboratory genomics method development; somatic mutation sequencing; duplex sequencing.
  • Hands on experience in qPCR, ddPCR.
  • Familiarity with bioinformatics tools.


Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.