Assistant Professor of Molecular and Human Genetics
Assistant Professor, Computational and Integrative Biomedical Research Center and Human Genome Sequencing Center
Ph.D., Baylor College of Medicine, 2005
Postdoc, Harvard Medical School, 2008
My research program is centered around high throughput DNA technologies. One major area that I focus on is computational tool development for next-generation sequencing (NGS) data analysis. We have developed two software packages (Atlas2 and SNPTools) for variation analysis in both personal genomic data and population sequencing data. They have been applied in a number of large-scale projects, including the 1000 Genomes Project, the Cancer Genome Atlas Project, CHARGE-S, and Autisms. Atlas2 also powers the backend of the BCM Whole Genome Laboratory (WGL) pipeline.
My close affiliation with the BCM Human Genome Sequencing Center allows me to stay updated on technologies in both the bench side and the computational side. My group interacts with others in the Center to drive the development and dissemination of the technologies. For example, we are in the process of developing an AWS Cloud based environment to address the genomic BIG DATA challenge.
I am also interested in both population genetics and human genetics. They are very active fields because of the abundance of datasets, and technological revolution in the sequencing arena. I have a number of ongoing collaborative projects in these areas.Fuli Yu, Ph.D.