Skip to Content

Fusobacterium nucleatum ATCC10953

About the Project

Image of Fusobacterium nucleatum
Fusobacterium nucleatum
George Weinstock (BCM-HGSC)
Susan Kinder Haake (UCLA), Sarah K. Highlander (Dept. of Molecular Virology and Microbiology, BCM)
R01 DE 013759-02
Genome size:
estimated 2.4 Mbp
ATCC 10953

Current Status of the Project

Latest assembly date: 6-13-2006
Total number of reads: 54,948
Coverage: 13x (for 2.4 Mb genome)
Number of contigs: 14
N50 contig size: 387,199 bp
Number of scaffolds: 1
N50 scaffold size: 2,429,598 bp

Search the Sequence

You can download the data from our FTP site.

Related Links

Karpathy SE, Qin X, Gioia J, Jiang H, Liu Y, et al. (2007) Genome Sequence of Fusobacterium nucleatum Subspecies Polymorphum ¿ a Genetically Tractable Fusobacterium. PLoS ONE 2(8): e659. doi:10.1371/journal. pone.0000659

Policy on Data Release

Fusobacterium nucleatum is an anaerobic Gram-negative non-sporeforming bacterium, and the type species for the genus Fuosbacterium. The species has a low G+C content (27 to 28%), and phylogenetic studies group the fusobacteria as a branch among the high and low G+C Gram-positive bacteria.

The cells of F. nucleatum are spindle-shaped or fusiform rods of variable length. All strains obtain energy from the fermentation of sugars or amino acids, and produce butyric acid as a major metabolic by-product. F. nucleatum is found in the dental plaque of primates, including man. This microorganism has been postulated to play a central role in dental plaque formation, based on its ability to adhere to a wide range of both Gram-positive and Gram-negative plaque microorganisms. F. nucleatum is frequently associated with periodontitis, as well as invasive human infections of the head and neck, chest, lung, liver and abdomen. Properties of F. nucleatum that may be related to virulence include it's adherence to and invasion of host tissue cells, and modulation of the host immune response. Native plasmids have been identified in strains of F. nucleatum, and an F. nucleatum - E. coli shuttle vector has been developed using the native plasmid pFN1.

Bolstad, A. I., H. B. Jensen, and V. Bakken. 1996. Taxonomy, biology, and periodontal aspects of Fusobacterium nucleatum. Clinical Microbiology Reviews 9(1):55-71.

Brook, I. 1988. Recovery of anaerobic bacteria from clinical specimens in 12 years at two military hospitals. Journal of Clinical Microbiology 26(6):1181-1188.

Civen, R., H. Jousimies-Somer, M. Marina, L. Borenstein, H. Shah, and S. M. Finegold. 1995. A retrospective review of cases of anaerobic empyema and update of bacteriology. Clinical Infectious Diseases 20 (Suppl 2):S224-S229.

Civen, R., M.-L. Visnen, and S. M. Finegold. 1993. Peritonsillar abscess, retropharyngeal abscess, mediastinitis, and nonclostridial anaerobic myonecrosis: A case report. Clinical Infectious Diseases 16 (Suppl. 4):S299-303.

Demuth, D. R., R. Savary, E. Golub, and B. J. Shenker. 1996. Identification and analysis of fipA, a Fusobacterium nucleatum immunosuppressive factor gene. Infection and Immunity 64(4):1335-1341.

Dzink, J. L., M. T. Sheenan, and S. S. Socransky. 1990. Proposal of three subspecies of Fusobacterium nucleatum Knorr 1922: Fusobacterium nucleatum subsp. nucleatum subsp. nov., comb. nov.; Fusobacterium nucleatum subsp. polymorphum subsp. nov., nom. rev., comb. nov.; and Fusobacterium nucleatum subsp. vincentii subsp. nov., nom. rev., comb. nov. International Journal of Systematic Bacteriology 40(1):74-78.

Goldstein, E. J. C., P. H. Summanen, D. M. Citron, M. H. Rosove, and S. M. Finegold. 1995. Fatal sepsis due to a b-lactamase-producing strain of Fusobacterium nucleatum subspecies polymorphum. Clinical Infectious Diseases 20:797-800.

Han, Y. W., W. Shi, G. T. Huang, S. Kinder Haake, N. H. Park, H. Kuramitsu, and R. J. Genco. 2000. Interactions between periodontal bacteria and human oral epithelial cells: Fusobacterium nucleatum adheres to and invades epithelial cells. Infect Immun 68(6):3140-6.

Jewett, A., W. R. Hume, H. Le, T. N. Huynh, Y. W. Han, G. Cheng, and W. Shi. 2000. Induction of apoptotic cell death in peripheral blood mononuclear and polymorphonuclear cells by an oral bacterium, Fusobacterium nucleatum. Infect Immun 68(4):1893-8.

Jousimies-Somer, H., S. Savolainen, A. M?kitie, and J. Ylikoski. 1993. Bacteriologic findings in peritonsillar abscesses in young adults. Clinical Infectious Diseases 16 (Suppl. 4):S292-298.

Kinder Haake, S., and R. A. Lindemann. 1997. Fusobacterium nucleatum T18 aggregates human mononuclear cells and inhibits their PHA-stimulated proliferation. Journal of Periodontology 68:39-44.

Kinder Haake, S., S. C. Yoder, G. Attarian, and K. Podkaminer. 2000. Native plasmids of Fusobacterium nucleatum: Characterization and use in development of genetic systems. Journal of Bacteriology 182(4):1176-1180.

Kolenbrander, P. E., and J. London. 1993. Adhere today, here tomorrow: Oral bacterial adherence. Journal of Bacteriology 175(11):3247-3252.

McKay, T. L., J. Ko, Y. Bilalis, and J. M. DiRienzo. 1995. Mobile genetic elements of Fusobacterium nucleatum. Plasmid 33:15-20.

Moore, W. E. C., L. V. Holdeman, and R. W. Kelley. 1984. Genus II. Fusobacterium, p. 631-637. In N. R. Krieg (ed.), Bergey's manual of systematic bacteriology, vol. 1. Williams and Wilkins, Baltimore.

Olsen, G. J., C. R. Woese, and R. Overbeek. 1994. The winds of (evolutionary) change: Breathing new life into microbiology. Journal of Bacteriology 176(1):1-6.

Ozaki, M., Y. Miyake, M. Shirakawa, T. Takemoto, H. Okamoto, and H. Suginaka. 1990. Binding specificity of Fusobacterium nucleatum to human erythrocytes, polymorphonuclear leukocytes, fibroblasts, and HeLa cells. Journal of Periodontal Research 25:129-134.

Robrish, S. A., and J. Thompson. 1990. Regulation of fructose metabolism and polymer synthesis by Fusobacterium nucleatum ATCC 10953. 172(10):5714-5723.

Rogers, A. H. 1998. Studies on fusobacteria associated with periodontal diseases. Aust Dent J 43(2):105-9.

Shenker, B. J., and S. Datar. 1995. Fusobacterium nucleatum inhibits human T-cell activation by arresting cells in the mid-G1 phase of the cell cycle. Infection and Immunity 63(12):4830-4836.

Tuttle, R. S., N. A. Strubel, J. Mourad, and D. F. Mangan. 1992. A non-lectin-like mechanism by which Fusobacterium nucleatum 10953 adheres to and activates human lymphocytes. Oral Microbiology and Immunology 7:78-83.

Related Publications

16S gut community of the Cameron County Hispanic Cohort., Ross, Matthew C., Muzny Donna M., McCormick Joseph B., Gibbs Richard A., Fisher-Hoch Susan P., and Petrosino Joseph F. , Microbiome, 2015, Volume 3, p.7, (2015) Abstract
Structure and function of the healthy pre-adolescent pediatric gut microbiome., Hollister, Emily B., Riehle Kevin, Luna Ruth Ann, Weidler Erica M., Rubio-Gonzales Michelle, Mistretta Toni-Ann, Raza Sabeen, Doddapaneni Harsha V., Metcalf Ginger A., Muzny Donna M., et al. , Microbiome, 2015, Volume 3, p.36, (2015) Abstract
Human Metabolome Associates With Dietary Intake Habits Among African Americans in the Atherosclerosis Risk in Communities Study., Zheng, Yan, Yu Bing, Alexander Danny, Steffen Lyn M., and Boerwinkle Eric , American journal of epidemiology, 2014 May 6, (2014) Abstract
Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment., Bull-Otterson, Lara, Feng Wenke, Kirpich Irina, Wang Yuhua, Qin Xiang, Liu Yanlong, Gobejishvili Leila, Joshi-Barve Swati, Ayvaz Tulin, Petrosino Joseph, et al. , PloS one, 2013, Volume 8, Issue 1, p.e53028, (2013) Abstract
Bioactivity and Bioavailability of Ginsenosides are Dependent on the Glycosidase Activities of the A/J Mouse Intestinal Microbiome Defined by Pyrosequencing., Niu, Tao, Smith Diane L., Yang Zhen, Gao Song, Yin Taijun, Jiang Zhi-Hong, You Ming, Gibbs Richard A., Petrosino Joseph F., and Hu Ming , Pharmaceutical research, 2013 Mar, Volume 30, Issue 3, p.836-46, (2013) Abstract
High throughput sequencing methods for microbiome profiling: application to food animal systems., Highlander, Sarah K. , Animal health research reviews / Conference of Research Workers in Animal Diseases, 2012 Jun, Volume 13, Issue 1, p.40-53, (2012) Abstract
A framework for human microbiome research., , Nature, 2012 Jun 14, Volume 486, Issue 7402, p.215-21, (2012) Abstract
Structure, function and diversity of the healthy human microbiome., , Nature, 2012 Jun 14, Volume 486, Issue 7402, p.207-14, (2012) Abstract
Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome., Saulnier, Delphine M., Riehle Kevin, Mistretta Toni-Ann, Diaz Maria-Alejandra, Mandal Debasmita, Raza Sabeen, Weidler Erica M., Qin Xiang, Coarfa Cristian, Milosavljevic Aleksandar, et al. , Gastroenterology, 2011 Nov, Volume 141, Issue 5, p.1782-91, (2011) Abstract
A catalog of reference genomes from the human microbiome., Nelson, Karen E., Weinstock George M., Highlander Sarah K., Worley Kim C., Creasy Heather Huot, Wortman Jennifer Russo, Rusch Douglas B., Mitreva Makedonka, Sodergren Erica, Chinwalla Asif T., et al. , Science (New York, N.Y.), 2010 May 21, Volume 328, Issue 5981, p.994-9, (2010) Abstract
Metagenomic pyrosequencing and microbial identification., Petrosino, Joseph F., Highlander Sarah, Luna Ruth Ann, Gibbs Richard A., and Versalovic James , Clinical chemistry, 2009 May, Volume 55, Issue 5, p.856-66, (2009) Abstract
about seo | page