Mouse Genome Project

Image source: George Shuklin (Own work) [CC-BY-SA-1.0], via Wikimedia Commons

About the Project

The BCM-HGSC has sequenced chromosomes 6 and 10 of the laboratory mouse (Mus musculus).

The genome sequence of the mouse was produced by the Mouse Genome Sequencing Consortium. BCM-HGSC finished 178Mb of redundant sequence or ~120 Mb of unique sequence for the mouse project that was completed in December 2005.

Funding for this project was provided by the NIH.

Genomic Resources

Access to the Data

Individual matched sequences (reads or assemblies) can be retrieved from the BCM-HGSC FTP site or from the NCBI Trace Archive using links below.

A three-way comparison of rat and human to mouse chromosomes found using Pash is available for browsing.

Additional Resources

Related Publications

Chen C-A, Pal R, Yin J, Tao H, Amawi A, Sabo A, et al.. Combination of whole exome sequencing and animal modeling identifies TMPRSS9 as a candidate gene for autism spectrum disorder. Hum Mol Genet. 2020 ;29(3):459-470.

Liu S, Tian M, He F, Li J, Xie H, Liu W, et al.. Mutations in ASH1L confer susceptibility to Tourette syndrome. Mol Psychiatry. 2020 ;25(2):476-490.

Liu J, Wu N, Yang N, Takeda K, Chen W, Li W, et al.. TBX6-associated congenital scoliosis (TACS) as a clinically distinguishable subtype of congenital scoliosis: further evidence supporting the compound inheritance and TBX6 gene dosage model. Genet Med. 2019 ;21(7):1548-1558.

Liang Q, Dharmat R, Owen L, Shakoor A, Li Y, Kim S, et al.. Single-nuclei RNA-seq on human retinal tissue provides improved transcriptome profiling. Nat Commun. 2019 ;10(1):5743.

Zaneveld SAgrawal, Eblimit A, Liang Q, Bertrand R, Wu N, Liu H, et al.. Gene Therapy Rescues Retinal Degeneration in Receptor Expression-Enhancing Protein 6 Mutant Mice. Hum Gene Ther. 2019 ;30(3):302-315.

Park YH, Snook JD, Ostrin EJ, Kim S, Chen R, Frankfort BJ. Transcriptomic profiles of retinal ganglion cells are defined by the magnitude of intraocular pressure elevation in adult mice. Sci Rep. 2019 ;9(1):2594.

Eblimit A, Zaneveld SAgrawal, Liu W, Thomas K, Wang K, Li Y, et al.. NMNAT1 E257K variant, associated with Leber Congenital Amaurosis (LCA9), causes a mild retinal degeneration phenotype. Exp Eye Res. 2018 ;173:32-43.

Guo L, Akahori H, Harari E, Smith SL, Polavarapu R, Karmali V, et al.. CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis. J Clin Invest. 2018 ;128(3):1106-1124.

Zhang L, Sun Z, Zhao P, Huang L, Xu M, Yang Y, et al.. Whole-exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa. Hum Mol Genet. 2018 ;27(23):4157-4168.

Eblimit A, Agrawal SAkshay, Thomas K, Anastassov IAssenov, Abulikemu T, Moayedi Y, et al.. Conditional loss of Spata7 in photoreceptors causes progressive retinal degeneration in mice. Exp Eye Res. 2018 ;166:120-130.