Mouse Genome Project

Image source: George Shuklin (Own work) [CC-BY-SA-1.0], via Wikimedia Commons

About the Project

The BCM-HGSC has sequenced chromosomes 6 and 10 of the laboratory mouse (Mus musculus).

The genome sequence of the mouse was produced by the Mouse Genome Sequencing Consortium. BCM-HGSC finished 178Mb of redundant sequence or ~120 Mb of unique sequence for the mouse project that was completed in December 2005.

Funding for this project was provided by the NIH.

Genomic Resources

Access to the Data

Individual matched sequences (reads or assemblies) can be retrieved from the BCM-HGSC FTP site or from the NCBI Trace Archive using links below.

A three-way comparison of rat and human to mouse chromosomes found using Pash is available for browsing.

Additional Resources

Related Publications

Vetrini F, D'Alessandro LCA, Akdemir ZC, Braxton A, Azamian MS, Eldomery MK, et al.. Bi-allelic Mutations in PKD1L1 Are Associated with Laterality Defects in Humans. Am J Hum Genet. 2016 ;99(4):886-893.

Loviglio MNicla, Beck CR, White JJ, Leleu M, Harel T, Guex N, et al.. Identification of a RAI1-associated disease network through integration of exome sequencing, transcriptomics, and 3D genomics. Genome Med. 2016 ;8(1):105.

Sorte HS, Osnes LT, Fevang B, Aukrust P, Erichsen HC, Backe PH, et al.. A potential founder variant in in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction. Mol Genet Genomic Med. 2016 ;4(6):604-616.

Chitsazzadeh V, Coarfa C, Drummond JA, Nguyen T, Joseph A, Chilukuri S, et al.. Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates. Nat Commun. 2016 ;7:12601.

Bayram Y, Gulsuner S, Guran T, Abaci A, Yesil G, Gulsuner HUnal, et al.. Homozygous loss-of-function mutations in SOHLH1 in patients with nonsyndromic hypergonadotropic hypogonadism. J Clin Endocrinol Metab. 2015 ;100(5):E808-14.

Mayle A, Yang L, Rodriguez B, Zhou T, Chang E, Curry CV, et al.. Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. Blood. 2015 ;125(4):629-38.

Xu M, Gelowani V, Eblimit A, Wang F, Young MP, Sawyer BL, et al.. ATF6 Is Mutated in Early Onset Photoreceptor Degeneration With Macular Involvement. Invest Ophthalmol Vis Sci. 2015 ;56(6):3889-95.

Zhong H, Eblimit A, Moayedi Y, Boye SL, Chiodo VA, Chen Y, et al.. AAV8(Y733F)-mediated gene therapy in a Spata7 knockout mouse model of Leber congenital amaurosis and retinitis pigmentosa. Gene Ther. 2015 ;22(8):619-27.

Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez-Pulido L, Williamson KA, et al.. Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations. Am J Hum Genet. 2014 ;94(6):915-23.

Yu Z, Kim J, He L, Creighton CJ, Gunaratne PH, Hawkins SM, et al.. Functional analysis of miR-34c as a putative tumor suppressor in high-grade serous ovarian cancer. Biol Reprod. 2014 ;91(5):113.