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The Cancer Genome Atlas Pan-Cancer analysis project.

TitleThe Cancer Genome Atlas Pan-Cancer analysis project.
Publication TypeJournal Article
Year of Publication2013
AuthorsWeinstein, John N., Collisson Eric A., Mills Gordon B., Shaw Kenna Mills R., Ozenberger Brad A., Ellrott Kyle, Shmulevich Ilya, Sander Chris, and Stuart Joshua M.
Corporate AuthorsCancer Genome Atlas Research Network
JournalNature genetics
Date Published2013 Oct
KeywordsGene Expression Profiling, Genome, Humans, Neoplasms
AbstractThe Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile.
Alternate JournalNat. Genet.

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