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Quantitative loci regulating plasma levels of gamma glutamyl transferase and albumin and their genetic correlations with cardiovascular risk factors.

TitleQuantitative loci regulating plasma levels of gamma glutamyl transferase and albumin and their genetic correlations with cardiovascular risk factors.
Publication TypeJournal Article
Year of Publication2009
AuthorsBose, Tanushree, Voruganti Saroja V., Tejero Elizabeth M., Proffitt Michael J., Cox Laura A., VandeBerg John L., Mahaney Michael C., Rogers Jeffrey, Freeland-Graves Jeanne H., Cole Shelley A., and Comuzzie Anthony G.
JournalExperimental biology and medicine (Maywood, N.J.)
Volume234
Issue12
Paginationvi, 1519-24
Date Published2009 Dec
ISSN1535-3699
KeywordsAnimals, Biological Markers, Cardiovascular Diseases, gamma-Glutamyltransferase, Genetic Markers, Genetic Predisposition to Disease, Humans, Liver, Lod Score, Papio hamadryas, Pedigree, Phenotype, Quantitative Trait Loci, Risk Factors, Serum Albumin
Abstractgamma Glutamyl transferase (GGT) and albumin (ALB) are two markers of liver function. These two proteins have been associated with non-alcoholic fatty liver disease and cardiovascular disease. The objectives of this study were to explore the genetic factors that influence variation in the plasma levels of GGT and ALB and to evaluate their genetic correlations with cardiovascular risk factors. Baboons from the Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX, were used as an animal model. The baboons were fed a standard monkey chow diet ad libitum. Fasting plasma concentrations of GGT, ALB, triglycerides, total cholesterol and LDL cholesterol were measured in 350 pedigreed adult baboons by standard assay procedures. A maximum likelihood-based variance decomposition approach implemented in the computer program SOLAR was used to conduct genetic analyses. The heritabilities of GGT (h(2) = 0.55; P < 0.0001) and ALB (h(2) = 0.42; P < 0.01) were significant. No statistically significant associations were found between GGT and the cardiovascular-related phenotypes. Genetic correlations between ALB and total cholesterol, LDL cholesterol and triglycerides were significant. A QTL (LOD = 2.8) for GGT plasma levels was identified on the baboon homologue of human chromosome 22 between markers D22S304 and D22S280. A QTL (LOD = 2.3) near marker D10S1432 was detected on the baboon homologue of human chromosome 10 for ALB. These results imply that variations in the plasma levels of GGT and ALB are under significant genetic regulation and that a common genetic component influences ALB and cardiovascular risk factor phenotypes.
DOI10.1371/journal.pgen.1000346
Alternate JournalExp. Biol. Med. (Maywood)


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