Skip to Content

Identification of a QTL for adipocyte volume and of shared genetic effects with aspartate aminotransferase.

TitleIdentification of a QTL for adipocyte volume and of shared genetic effects with aspartate aminotransferase.
Publication TypeJournal Article
Year of Publication2010
AuthorsBose, Tanushree, Voruganti Saroja V., Tejero Elizabeth M., Proffit Michael J., Cox Laura A., VandeBerg John L., Mahaney Michael C., Rogers Jeffrey, Freeland-Graves Jeanne H., Cole Shelley A., and Comuzzie Anthony G.
JournalBiochemical genetics
Volume48
Issue5-6
Pagination538-47
Date Published2010 Jun
ISSN1573-4927
KeywordsAdipocytes, Animals, Aspartate Aminotransferases, Biological Markers, Cell Size, Female, Genomics, Humans, Male, Obesity, Papio, Quantitative Trait Loci
AbstractPlasma levels of aspartate aminotransferase (AST), a liver enzyme, are elevated in patients with visceral obesity. This study examined whether adipocyte volume is under the influence of genetic factors and evaluated its genetic correlations with AST. Fasting plasma levels of 344 pedigreed baboons from the Southwest National Primate Research Center in San Antonio, TX, USA, were assayed for AST. Adipocyte volume was measured using biopsies of omental adipose tissue. Adipocyte volume, body weight, and plasma AST were heritable. Genetic correlations between the measured adiposity-related phenotypes and AST were significant. A quantitative trait locus (LOD score 3.2) for adipocyte volume was identified on the baboon homolog of human chromosome 6 near marker D6S1028. These results suggest that omental adipocyte volume is under genetic regulation and that shared genetic factors influence adiposity-associated traits and AST.
DOI10.1371/journal.pgen.1000346
Alternate JournalBiochem. Genet.


about seo | biblio