|Title||Serum prostate specific antigen changes in cynomolgus monkeys (Macaca fascicularis) on a high sugar high fat diet. |
|Publication Type||Journal Article |
|Year of Publication||2012 |
|Authors||Mubiru, James N., Garcia-Forey Magdalena, Cavazos Nicole, Hemmat Peggah, Dick Edward J., Owston Michael A., Bauer Cassondra A., Shade Robert E., and Rogers Jeffrey |
|Journal||The Prostate |
|Date Published||2012 Apr |
|Keywords||Absorptiometry, Photon, Animals, Blood Glucose, Body Mass Index, Body Weight, Dietary Carbohydrates, Dietary Fats, Disease Models, Animal, Insulin, Insulin Resistance, Macaca fascicularis, Male, Obesity, Organ Size, Prostate, Prostate-Specific Antigen |
|Abstract||BACKGROUND: An inverse relationship between serum prostate specific antigen (PSA) levels and body mass index (BMI) has been reported in men but not in any animal model.
METHODS: Serum PSA in a colony of cynomolgus monkeys was assayed and correlated to body weight, prostate weight, and age. In addition, 15 animals were selected and fed a high sugar high fat (HSHF) diet for 49 weeks to increase their BMI and correlate it to PSA RESULTS: Serum PSA levels were positively correlated to prostate weight (r = 0.515, P = 0.025) and age (r = 0.548, P = 0.00072) but was not significantly correlated to body weight (r = -0.032, P = 0.419). For the animals on the HSHF diet, body weight, lean mass, fat mass, and BMI were significantly higher at 49 weeks than at baseline (P < 0.01). PSA was not significantly correlated to body weight and insulin at both baseline and 49 weeks. PSA was negatively correlated to BMI and insulin resistance (HOMA-IR) at 49 weeks but not at baseline. In addition, we observed hepatic steatosis and increases in serum liver enzymes.
CONCLUSIONS: Increases in BMI in cynomolgus monkeys as a result of consuming a HSHF diet resulted in PSA changes similar to those in humans with increased BMI. Cynomolgus monkeys are a useful model for investigating the relationship between obesity, diabetes, and PSA changes resulting from prostate gland pathology. |
|Alternate Journal||Prostate |