Baboon Genome Project

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Olive baboon. Image source: Stolz, Gary M. [Public domain], via Wikimedia Commons

About the Project

Diversity Panel

Image: Chacma baboon

Chacma baboon

Image source: BBC

 

Image: Guinea baboon

Guinea baboon

Image source: BBC

 

Image: Hamadrayas baboon

Hamadrayas baboon

Image source: Wisconsin National Primate Research Center

 

Image: Kinda baboon

Kinda baboon

 

Image: Yellow baboon

Yellow baboon

The BCM-HGSC is sequencing and analyzing the genome of the baboon (genus Papio). A high quality draft sequence of the reference genome has been produced from an olive baboon (Papio anubis), using read data produced by the Sanger, 454 and Illumina platforms. 

In addition to the deep sequence coverage of the reference olive baboon, BCM-HGSC has generated whole genome coverage from additional olive baboons, as well as individuals representing hamadryas (P. hamadryas), Guinea (P. papio), yellow (P. cynocephalus), chacma (P. ursinus) and kinda (P. kindae) baboons. Comparative analyses of these data are in progress and will result in a description of genomic diversity within and among species of the genus Papio. Comparisons with the human and other nonhuman primate genomes are also in progress.

Baboons are important both as a well-studied and diverse evolutionary radiation of Old World monkeys, and as laboratory primates commonly used in biomedical research. Although closely related, the species within this genus differ in social behavior, ecology, body size and other fundamental characteristics. In the laboratory, baboons are used as models of several human diseases, including cardiovascular disease, obesity, hypertension, epilepsy, infectious disease and various aspects of basic neurobiology.

The project is funded by the National Human Genome Research Institute (NHGRI).

Diversity Panel

  • Chacma baboon (P. ursinus)
  • Guinea baboon (P. papio)
  • Hamadrayas baboon (P. hamadrayas)
  • Kinda baboon (P. kindae)
  • Yellow baboon (P. cynocephalus)
  • Additional Olive baboons (P. anubis)

Genomic Resources

Related Publications

D Miley D, Baumgartner MH, Cheverud JM, Roseman CC, Rogers J, McLeod DE, et al. Heritability of alveolar bone loss from periodontal disease in a baboon population: a pilot study. J Periodontol. 2011 ;82(4):575-80.

Roseman CC, Willmore KE, Rogers J, Hildebolt C, Sadler BE, Richtsmeier JT, et al. Genetic and environmental contributions to variation in baboon cranial morphology. Am J Phys Anthropol. 2010 ;143(1):1-12.

Bose T, V Voruganti S, M Tejero E, J Proffit M, Cox LA, VandeBerg JL, et al. Identification of a QTL for adipocyte volume and of shared genetic effects with aspartate aminotransferase. Biochem Genet. 2010 ;48(5-6):538-47.

Rogers J, Kochunov P, Zilles K, Shelledy W, Lancaster J, Thompson P, et al. On the genetic architecture of cortical folding and brain volume in primates. Neuroimage. 2010 ;53(3):1103-8.

Willmore KE, Roseman CC, Rogers J, Cheverud JM, Richtsmeier JT. Comparison of Mandibular Phenotypic and Genetic Integration between Baboon and Mouse. Evol Biol. 2009 ;36(1):19-36.

Bose T, V Voruganti S, M Tejero E, J Proffitt M, Cox LA, VandeBerg JL, et al. Quantitative loci regulating plasma levels of gamma glutamyl transferase and albumin and their genetic correlations with cardiovascular risk factors. Exp Biol Med (Maywood). 2009 ;234(12):vi, 1519-24.

Li J, Han K, Xing J, Kim H-S, Rogers J, Ryder OA, et al. Phylogeny of the macaques (Cercopithecidae: Macaca) based on Alu elements. Gene. 2009 ;448(2):242-9.

Rainwater DL, Cox LA, Rogers J, VandeBerg JL, Mahaney MC. Localization of multiple pleiotropic genes for lipoprotein metabolism in baboons. J Lipid Res. 2009 ;50(7):1420-8.

Willmore KE, Roseman CC, Rogers J, Richtsmeier JT, Cheverud JM. Genetic variation in baboon craniofacial sexual dimorphism. Evolution. 2009 ;63(3):799-806.