Harsha Doddapaneni, Ph.D.

Assistant Professor, Department of Molecular and Human Genetics

Image: Harsha Doddapaneni, Ph.D.Contact information

doddapan@bcm.edu

Education

2004: Ph. D, Genetics, Osmania University/ICRISAT, Hyderabad, India

2002 - 2005: Visiting Scholar, Fungal Genomics, University of Cincinnati, Cincinnati, USA

2005 – 2008: PostDoc, Plant-Bacterial Genomics, University of California, Davis, USDA/ARS, Parlier, California, USA

Awards and honors

1996-2002 National CSIR-UGC Research Fellowship, India

Research Interests

I have a broad background in molecular biology and genomics, with specific training and expertise in key research areas of NGS sample preparation and management of large scale sample preparation operations. Since joining the BCM-HGSC in 2012, I have directed the front-end procedures of sample intake, DNA and RNA library construction for next-gen platforms and exome capture. My team has built automated library preparation pipelines for HiSeq and NovaSeq platforms, and developed multiple protocols for DNA and RNA sequencing from challenging samples. I also have considerable experience in evaluation of emerging technologies in the genomics space. I am currently leading long read sequencing effort for large scale sequencing programs and also providing technical support to the HGSC-Clinical Laboratory for sample preparation and sequencing.

Before joining HGSC, I served as the director for Carver Center for Genomics (CCG) at the University of Iowa (2008-2012), where I oversaw genomics projects and managed the center’s ‘Certified Service Provider’ program for Roche NimbleGen microarray applications.

Publications

Harrison MC, Jongepier E, Robertson HM, et al. Hemimetabolous genomes reveal molecular basis of termite eusociality. Nat Ecol Evol. 2018;2(3):557-566. doi:10.1038/s41559-017-0459-1.

Tanner J-A, Zhu AZ, Claw KG, et al. Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism. Pharmacogenet Genomics. 2018;28(1):7-16. doi:10.1097/FPC.0000000000000317.

Lindsey ARI, Kelkar YD, Wu X, et al. Comparative genomics of the miniature wasp and pest control agent Trichogramma pretiosum. BMC Biol. 2018;16(1):54. doi:10.1186/s12915-018-0520-9.

Poynton HC, Hasenbein S, Benoit JB, et al. The Toxicogenome of Hyalella azteca: A Model for Sediment Ecotoxicology and Evolutionary Toxicology. Environ Sci Technol. 2018;52(10):6009-6022. doi:10.1021/acs.est.8b00837.

Dinckan N, Du R, Akdemir ZC, et al. A biallelic ANTXR1 variant expands the anthrax toxin receptor associated phenotype to tooth agenesis. Am J Med Genet A. 2018;176(4):1015-1022. doi:10.1002/ajmg.a.38625.

Eldomery MK, Coban-Akdemir Z, Harel T, et al. Lessons learned from additional research analyses of unsolved clinical exome cases. Genome Med. 2017;9(1):26. doi:10.1186/s13073-017-0412-6.

Dinckan N, Du R, Petty LE, et al. Whole-Exome Sequencing Identifies Novel Variants for Tooth Agenesis. J Dent Res. 2017:22034517724149. doi:10.1177/0022034517724149.

Schwager EE, Sharma PP, Clarke T, et al. The house spider genome reveals an ancient whole-genome duplication during arachnid evolution. BMC Biol. 2017;15(1):62. doi:10.1186/s12915-017-0399-x.