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Richard Gibbs, Ph.D.

Director, Baylor College of Medicine Human Genome Sequencing Center

image: Richard Gibbs, Ph.D.Contact information

agibbs@bcm.edu

Other positions

Wofford Cain Chair in Molecular and Human Genetics

Professor, Department of Molecular and Human Genetics

Professor, Programs in Integrative Molecular and Biomedical Sciences and Translational Biology & Molecular Medicine

Education

B.Sc., University of Melbourne, 1979

Ph.D., University of Melbourne, 1985

Postdoc, Baylor College of Medicine, 1990

Awards and honors

2011: Elected to membership in the Institute of Medicine

2001: LSU Chancellor's Distinguished Lectureship

2000: Michael E. DeBakey, M.D., Excellence in Research Award

1988-1989: George R. Sampson Distinguished Research Fellowship, Muscular Dystrophy Association

1987: American Arthritis Foundation, Postdoctoral Fellowship

1986: Muscular Dystrophy Association of America, Postdoctoral Fellowship

Research interests

Richard Gibbs is the Founder and Director of the BCM-HGSC, established at BCM in 1996. The BCM-HGSC has a core mission of advancing medical care through research and translation of genomics. The group was one of the five worldwide sites to undertake and complete the Human Genome Project, culminating in contribution of approximately ten percent of the sequence in 2003. The group subsequently collaborated to sequence many key species (Drosophila melanogaster, the Brown Norway rat, rhesus macaque, bovine, Dictyostelium discoideum, sea urchin and honey bee genomes) and to generate the first comprehensive map of human genetic variation (the HapMap project). The BCM-HGSC now employs more than 180 staff, including eighteen faculty.

Since 2007, new technologies have allowed unprecedented advances in human genetics. The BCM-HGSC pioneered whole exome capture methods and published the first diploid sequence of a human, James Watson. Next we demonstrated the utility of whole genome sequencing for genetic disease discovery and for guiding effective clinical treatments. In 2011, we began deploying these methods into routine clinical practice and now provide full gene sequencing to hundreds of individual patients each month.

Current research within the BCM-HGSC is focused upon the genomics of cancer, heart disease and autism. To achieve this the group is sequencing single human genomes at an increasing rate. New molecular technologies are being developed for the mapping and sequencing, for exploring novel chemistries for DNA tagging, and to enable development of instrumentation for DNA manipulation. The HGSC is also part of the national program for systematic discovery of the cause of human single genome defects and has an active bioinformatics program, with research projects involving biologists and computer scientists. Problems under study focus on developing tools for generating, manipulating, and analyzing genome data.

Publications

Comparison of gene indexing databases., Bouck, J., Yu W., Gibbs R., and Worley K. , Trends in genetics : TIG, 1999 Apr, Volume 15, Issue 4, p.159-62, (1999)
Somatic sequence variation at the Friedreich ataxia locus includes complete contraction of the expanded GAA triplet repeat, significant length variation in serially passaged lymphoblasts and enhanced mutagenesis in the flanking sequence., Bidichandani, S. I., Purandare S. M., Taylor E. E., Gumin G., Machkhas H., Harati Y., Gibbs R. A., Ashizawa T., and Patel P. I. , Human molecular genetics, 1999 Dec, Volume 8, Issue 13, p.2425-36, (1999) Abstract
The weed paves the way., Gibbs, R. A. , Nature genetics, 1999 Jul, Volume 22, Issue 3, p.219-20, (1999)
An allylic/acyclic adenosine nucleoside triphosphate for termination of DNA synthesis by DNA template-dependent polymerases., Martinez, C. I., Thoresen L. H., Gibbs R. A., and Burgess K. , Nucleic acids research, 1999 Mar 1, Volume 27, Issue 5, p.1271-4, (1999) Abstract
DNA deletion confined to the iduronate-2-sulfatase promoter abolishes IDS gene expression., Timms, K. M., Huckett L. E., Belmont J. W., Shapira S. K., and Gibbs R. A. , Human mutation, 1998, Volume 11, Issue 2, p.121-6, (1998) Abstract
Reassessment of biochemically determined Hunter syndrome carrier status by DNA testing., Timms, K. M., Edwards F. J., Belmont J. W., Yates J. R., and Gibbs R. A. , Journal of medical genetics, 1998 Aug, Volume 35, Issue 8, p.646-9, (1998) Abstract
Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6., Ansari-Lari, M. A., Oeltjen J. C., Schwartz S., Zhang Z., Muzny D. M., Lu J., Gorrell J. H., Chinault A. C., Belmont J. W., Miller W., et al. , Genome research, 1998 Jan, Volume 8, Issue 1, p.29-40, (1998) Abstract
Elimination of residual natural nucleotides from 3'-O-modified-dNTP syntheses by enzymatic mop-up., Metzker, M. L., Raghavachari R., Burgess K., and Gibbs R. A. , BioTechniques, 1998 Nov, Volume 25, Issue 5, p.814-7, (1998) Abstract
Using BODIPY dye-primer chemistry in large-scale sequencing., Muzny, D. M., Metzker M. L., Bouck J., Gorrell J. H., Ding Y., Maxim E., and Gibbs R. A. , IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society, 1998 Nov-Dec, Volume 17, Issue 6, p.88-93, (1998)
Analysis of the quality and utility of random shotgun sequencing at low redundancies., Bouck, J., Miller W., Gorrell J. H., Muzny D., and Gibbs R. A. , Genome research, 1998 Oct, Volume 8, Issue 10, p.1074-84, (1998) Abstract
Quantitation of mixed-base populations of HIV-1 variants by automated DNA sequencing with BODIPY dye-labeled primers., Metzker, M. L., Ansari-Lari M. A., Liu X. M., Holder D. J., and Gibbs R. A. , BioTechniques, 1998 Sep, Volume 25, Issue 3, p.446-7, 450-2, 454, passim, (1998) Abstract
The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP)., Timms, K. M., Ansari-Lari M. A., Morris W., Brown S. N., and Gibbs R. A. , Gene, 1998 Sep 14, Volume 217, Issue 1-2, p.101-6, (1998) Abstract
Simultaneous shotgun sequencing of multiple cDNA clones., Andersson, B., Lu J., Shen Y., Wentland M. A., and Gibbs R. A. , DNA sequence : the journal of DNA sequencing and mapping, 1997, Volume 7, Issue 2, p.63-70, (1997) Abstract
Large-scale concatenation cDNA sequencing., Yu, W., Andersson B., Worley K. C., Muzny D. M., Ding Y., Liu W., Ricafrente J. Y., Wentland M. A., Lennon G., and Gibbs R. A. , Genome research, 1997 Apr, Volume 7, Issue 4, p.353-8, (1997) Abstract
Large-scale concatenation cDNA sequencing., Yu, W., Andersson B., Worley K. C., Muzny D. M., Ding Y., Liu W., Ricafrente J. Y., Wentland M. A., Lennon G., and Gibbs R. A. , Genome research, 1997 Apr, Volume 7, Issue 4, p.353-8, (1997) Abstract
Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains., Oeltjen, J. C., Malley T. M., Muzny D. M., Miller W., Gibbs R. A., and Belmont J. W. , Genome research, 1997 Apr, Volume 7, Issue 4, p.315-29, (1997) Abstract
Test of the potential of a dATP surrogate for sequencing via MALDI-MS., Jacutin, S., Zhang A. J., Russell D. H., Gibbs R. A., and Burgess K. , Nucleic acids research, 1997 Dec 15, Volume 25, Issue 24, p.5072-6, (1997) Abstract
The extent of genetic variation in the CCR5 gene., Ansari-Lari, M. A., Liu X. M., Metzker M. L., Rut A. R., and Gibbs R. A. , Nature genetics, 1997 Jul, Volume 16, Issue 3, p.221-2, (1997)
Sequencing and functional analysis of the SNRPN promoter: in vitro methylation abolishes promoter activity., Huq, A. H., Sutcliffe J. S., Nakao M., Shen Y., Gibbs R. A., and Beaudet A. L. , Genome research, 1997 Jun, Volume 7, Issue 6, p.642-8, (1997) Abstract
Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination., Ansari-Lari, M. A., Shen Y., Muzny D. M., Lee W., and Gibbs R. A. , Genome research, 1997 Mar, Volume 7, Issue 3, p.268-80, (1997) Abstract
Molecular and phenotypic variation in patients with severe Hunter syndrome., Timms, K. M., Bondeson M. L., Ansari-Lari M. A., Lagerstedt K., Muzny D. M., Dugan-Rocha S. P., Nelson D. L., Pettersson U., and Gibbs R. A. , Human molecular genetics, 1997 Mar, Volume 6, Issue 3, p.479-86, (1997) Abstract
Hares and tortoises in the race to sequence the human genome: expectations and realities., Gibbs, R. A. , Trends in genetics : TIG, 1997 Oct, Volume 13, Issue 10, p.381-3, (1997)
The human COX10 gene is disrupted during homologous recombination between the 24 kb proximal and distal CMT1A-REPs., Reiter, L. T., Murakami T., Koeuth T., Gibbs R. A., and Lupski J. R. , Human molecular genetics, 1997 Sep, Volume 6, Issue 9, p.1595-603, (1997) Abstract
A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13., Ansari-Lari, M. A., Muzny D. M., Lu J., Lu F., Lilley C. E., Spanos S., Malley T., and Gibbs R. A. , Genome research, 1996 Apr, Volume 6, Issue 4, p.314-26, (1996) Abstract
A "double adaptor" method for improved shotgun library construction., Andersson, B., Wentland M. A., Ricafrente J. Y., Liu W., and Gibbs R. A. , Analytical biochemistry, 1996 Apr 5, Volume 236, Issue 1, p.107-13, (1996) Abstract


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