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Richard Gibbs, Ph.D.

Director, Baylor College of Medicine Human Genome Sequencing Center

image: Richard Gibbs, Ph.D.Contact information

Other positions

Wofford Cain Chair in Molecular and Human Genetics

Professor, Department of Molecular and Human Genetics

Professor, Programs in Integrative Molecular and Biomedical Sciences and Translational Biology & Molecular Medicine


B.Sc., University of Melbourne, 1979

Ph.D., University of Melbourne, 1985

Postdoc, Baylor College of Medicine, 1990

Awards and honors

2011: Elected to membership in the Institute of Medicine

2001: LSU Chancellor's Distinguished Lectureship

2000: Michael E. DeBakey, M.D., Excellence in Research Award

1988-1989: George R. Sampson Distinguished Research Fellowship, Muscular Dystrophy Association

1987: American Arthritis Foundation, Postdoctoral Fellowship

1986: Muscular Dystrophy Association of America, Postdoctoral Fellowship

Research interests

Richard Gibbs is the Founder and Director of the BCM-HGSC, established at BCM in 1996. The BCM-HGSC has a core mission of advancing medical care through research and translation of genomics. The group was one of the five worldwide sites to undertake and complete the Human Genome Project, culminating in contribution of approximately ten percent of the sequence in 2003. The group subsequently collaborated to sequence many key species (Drosophila melanogaster, the Brown Norway rat, rhesus macaque, bovine, Dictyostelium discoideum, sea urchin and honey bee genomes) and to generate the first comprehensive map of human genetic variation (the HapMap project). The BCM-HGSC now employs more than 180 staff, including eighteen faculty.

Since 2007, new technologies have allowed unprecedented advances in human genetics. The BCM-HGSC pioneered whole exome capture methods and published the first diploid sequence of a human, James Watson. Next we demonstrated the utility of whole genome sequencing for genetic disease discovery and for guiding effective clinical treatments. In 2011, we began deploying these methods into routine clinical practice and now provide full gene sequencing to hundreds of individual patients each month.

Current research within the BCM-HGSC is focused upon the genomics of cancer, heart disease and autism. To achieve this the group is sequencing single human genomes at an increasing rate. New molecular technologies are being developed for the mapping and sequencing, for exploring novel chemistries for DNA tagging, and to enable development of instrumentation for DNA manipulation. The HGSC is also part of the national program for systematic discovery of the cause of human single genome defects and has an active bioinformatics program, with research projects involving biologists and computer scientists. Problems under study focus on developing tools for generating, manipulating, and analyzing genome data.


Sequencing and functional analysis of the SNRPN promoter: in vitro methylation abolishes promoter activity., Huq, A. H., Sutcliffe J. S., Nakao M., Shen Y., Gibbs R. A., and Beaudet A. L. , Genome research, 1997 Jun, Volume 7, Issue 6, p.642-8, (1997) Abstract
Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination., Ansari-Lari, M. A., Shen Y., Muzny D. M., Lee W., and Gibbs R. A. , Genome research, 1997 Mar, Volume 7, Issue 3, p.268-80, (1997) Abstract
Molecular and phenotypic variation in patients with severe Hunter syndrome., Timms, K. M., Bondeson M. L., Ansari-Lari M. A., Lagerstedt K., Muzny D. M., Dugan-Rocha S. P., Nelson D. L., Pettersson U., and Gibbs R. A. , Human molecular genetics, 1997 Mar, Volume 6, Issue 3, p.479-86, (1997) Abstract
Hares and tortoises in the race to sequence the human genome: expectations and realities., Gibbs, R. A. , Trends in genetics : TIG, 1997 Oct, Volume 13, Issue 10, p.381-3, (1997)
The human COX10 gene is disrupted during homologous recombination between the 24 kb proximal and distal CMT1A-REPs., Reiter, L. T., Murakami T., Koeuth T., Gibbs R. A., and Lupski J. R. , Human molecular genetics, 1997 Sep, Volume 6, Issue 9, p.1595-603, (1997) Abstract
A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13., Ansari-Lari, M. A., Muzny D. M., Lu J., Lu F., Lilley C. E., Spanos S., Malley T., and Gibbs R. A. , Genome research, 1996 Apr, Volume 6, Issue 4, p.314-26, (1996) Abstract
A "double adaptor" method for improved shotgun library construction., Andersson, B., Wentland M. A., Ricafrente J. Y., Liu W., and Gibbs R. A. , Analytical biochemistry, 1996 Apr 5, Volume 236, Issue 1, p.107-13, (1996) Abstract
Improved ligation-anchored PCR strategy for identification of 5' ends of transcripts., Ansari-Lari, M. A., Jones S. N., Timms K. M., and Gibbs R. A. , BioTechniques, 1996 Jul, Volume 21, Issue 1, p.34-6, 38, (1996)
Duplication of a gene-rich cluster between 16p11.1 and Xq28: a novel pericentromeric-directed mechanism for paralogous genome evolution., Eichler, E. E., Lu F., Shen Y., Antonacci R., Jurecic V., Doggett N. A., Moyzis R. K., Baldini A., Gibbs R. A., and Nelson D. L. , Human molecular genetics, 1996 Jul, Volume 5, Issue 7, p.899-912, (1996) Abstract
Method for 96-well M13 DNA template preparations for large-scale sequencing., Andersson, B., Lu J., Edwards K. E., Muzny D. M., and Gibbs R. A. , BioTechniques, 1996 Jun, Volume 20, Issue 6, p.1022-7, (1996) Abstract
Expression of human immunodeficiency virus type 1 reverse transcriptase in trans during virion release and after infection., Ansari-Lari, M. A., and Gibbs R. A. , Journal of virology, 1996 Jun, Volume 70, Issue 6, p.3870-5, (1996) Abstract
A recombination hotspot responsible for two inherited peripheral neuropathies is located near a mariner transposon-like element., Reiter, L. T., Murakami T., Koeuth T., Pentao L., Muzny D. M., Gibbs R. A., and Lupski J. R. , Nature genetics, 1996 Mar, Volume 12, Issue 3, p.288-97, (1996) Abstract
Electrophoretically uniform fluorescent dyes for automated DNA sequencing., Metzker, M. L., Lu J., and Gibbs R. A. , Science (New York, N.Y.), 1996 Mar 8, Volume 271, Issue 5254, p.1420-2, (1996) Abstract
Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island., Gu, Y., Shen Y., Gibbs R. A., and Nelson D. L. , Nature genetics, 1996 May, Volume 13, Issue 1, p.109-13, (1996) Abstract
Genomic organization of the mouse double minute 2 gene., Jones, S. N., Ansari-Lari M. A., Hancock A. R., Jones W. J., Gibbs R. A., Donehower L. A., and Bradley A. , Gene, 1996 Oct 10, Volume 175, Issue 1-2, p.209-13, (1996) Abstract
Complete sequence of a 38.4-kb human cosmid insert containing the polymorphic marker DXS455 from Xq28., Andersson, B., Lu F., Muzny D. M., Warren S. T., and Gibbs R. A. , DNA sequence : the journal of DNA sequencing and mapping, 1995, Volume 5, Issue 4, p.219-23, (1995) Abstract
Detection and genetic analysis of beta-thalassemia mutations by competitive oligopriming., Athanassiadou, A., Papachatzopoulou A., and Gibbs R. A. , Human mutation, 1995, Volume 6, Issue 1, p.30-5, (1995) Abstract
Accurate determination of DNA in agarose gels using the novel algorithm GelScann(1.0)., Metzker, M. L., Allain K. M., and Gibbs R. A. , Computer applications in the biosciences : CABIOS, 1995 Apr, Volume 11, Issue 2, p.187-94, (1995) Abstract
Working on the assembly line., Gibbs, R. A., and Cockerill M. , Trends in biochemical sciences, 1995 Apr, Volume 20, Issue 4, p.162-3, (1995)
130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus., Timms, K. M., Lu F., Shen Y., Pierson C. A., Muzny D. M., Gu Y., Nelson D. L., and Gibbs R. A. , Genome research, 1995 Aug, Volume 5, Issue 1, p.71-8, (1995) Abstract
Analysis of human immunodeficiency virus type 1 integrase mutants., Ansari-Lari, M. A., Donehower L. A., and Gibbs R. A. , Virology, 1995 Aug 1, Volume 211, Issue 1, p.332-5, (1995) Abstract
Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci., Oeltjen, J. C., Liu X., Lu J., Allen R. C., Muzny D., Belmont J. W., and Gibbs R. A. , Mammalian genome : official journal of the International Mammalian Genome Society, 1995 May, Volume 6, Issue 5, p.334-8, (1995) Abstract
Pressing ahead with human genome sequencing., Gibbs, R. A. , Nature genetics, 1995 Oct, Volume 11, Issue 2, p.121-5, (1995) Abstract
Fine structure of the human FMR1 gene., Eichler, E. E., Richards S., Gibbs R. A., and Nelson D. L. , Human molecular genetics, 1994 Apr, Volume 3, Issue 4, p.684-5, (1994)
Multiplex PCR: advantages, development, and applications., Edwards, M. C., and Gibbs R. A. , PCR methods and applications, 1994 Feb, Volume 3, Issue 4, p.S65-75, (1994)

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