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Richard Gibbs, Ph.D.

Director, Baylor College of Medicine Human Genome Sequencing Center

image: Richard Gibbs, Ph.D.Contact information

agibbs@bcm.edu

Other positions

Wofford Cain Chair in Molecular and Human Genetics

Professor, Department of Molecular and Human Genetics

Professor, Programs in Integrative Molecular and Biomedical Sciences and Translational Biology & Molecular Medicine

Education

B.Sc., University of Melbourne, 1979

Ph.D., University of Melbourne, 1985

Postdoc, Baylor College of Medicine, 1990

Awards and honors

2011: Elected to membership in the Institute of Medicine

2001: LSU Chancellor's Distinguished Lectureship

2000: Michael E. DeBakey, M.D., Excellence in Research Award

1988-1989: George R. Sampson Distinguished Research Fellowship, Muscular Dystrophy Association

1987: American Arthritis Foundation, Postdoctoral Fellowship

1986: Muscular Dystrophy Association of America, Postdoctoral Fellowship

Research interests

Richard Gibbs is the Founder and Director of the BCM-HGSC, established at BCM in 1996. The BCM-HGSC has a core mission of advancing medical care through research and translation of genomics. The group was one of the five worldwide sites to undertake and complete the Human Genome Project, culminating in contribution of approximately ten percent of the sequence in 2003. The group subsequently collaborated to sequence many key species (Drosophila melanogaster, the Brown Norway rat, rhesus macaque, bovine, Dictyostelium discoideum, sea urchin and honey bee genomes) and to generate the first comprehensive map of human genetic variation (the HapMap project). The BCM-HGSC now employs more than 180 staff, including eighteen faculty.

Since 2007, new technologies have allowed unprecedented advances in human genetics. The BCM-HGSC pioneered whole exome capture methods and published the first diploid sequence of a human, James Watson. Next we demonstrated the utility of whole genome sequencing for genetic disease discovery and for guiding effective clinical treatments. In 2011, we began deploying these methods into routine clinical practice and now provide full gene sequencing to hundreds of individual patients each month.

Current research within the BCM-HGSC is focused upon the genomics of cancer, heart disease and autism. To achieve this the group is sequencing single human genomes at an increasing rate. New molecular technologies are being developed for the mapping and sequencing, for exploring novel chemistries for DNA tagging, and to enable development of instrumentation for DNA manipulation. The HGSC is also part of the national program for systematic discovery of the cause of human single genome defects and has an active bioinformatics program, with research projects involving biologists and computer scientists. Problems under study focus on developing tools for generating, manipulating, and analyzing genome data.

Publications

Expression of human immunodeficiency virus type 1 reverse transcriptase in trans during virion release and after infection., Ansari-Lari, M. A., and Gibbs R. A. , Journal of virology, 1996 Jun, Volume 70, Issue 6, p.3870-5, (1996) Abstract
A recombination hotspot responsible for two inherited peripheral neuropathies is located near a mariner transposon-like element., Reiter, L. T., Murakami T., Koeuth T., Pentao L., Muzny D. M., Gibbs R. A., and Lupski J. R. , Nature genetics, 1996 Mar, Volume 12, Issue 3, p.288-97, (1996) Abstract
Electrophoretically uniform fluorescent dyes for automated DNA sequencing., Metzker, M. L., Lu J., and Gibbs R. A. , Science (New York, N.Y.), 1996 Mar 8, Volume 271, Issue 5254, p.1420-2, (1996) Abstract
Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island., Gu, Y., Shen Y., Gibbs R. A., and Nelson D. L. , Nature genetics, 1996 May, Volume 13, Issue 1, p.109-13, (1996) Abstract
Genomic organization of the mouse double minute 2 gene., Jones, S. N., Ansari-Lari M. A., Hancock A. R., Jones W. J., Gibbs R. A., Donehower L. A., and Bradley A. , Gene, 1996 Oct 10, Volume 175, Issue 1-2, p.209-13, (1996) Abstract
Complete sequence of a 38.4-kb human cosmid insert containing the polymorphic marker DXS455 from Xq28., Andersson, B., Lu F., Muzny D. M., Warren S. T., and Gibbs R. A. , DNA sequence : the journal of DNA sequencing and mapping, 1995, Volume 5, Issue 4, p.219-23, (1995) Abstract
Detection and genetic analysis of beta-thalassemia mutations by competitive oligopriming., Athanassiadou, A., Papachatzopoulou A., and Gibbs R. A. , Human mutation, 1995, Volume 6, Issue 1, p.30-5, (1995) Abstract
Accurate determination of DNA in agarose gels using the novel algorithm GelScann(1.0)., Metzker, M. L., Allain K. M., and Gibbs R. A. , Computer applications in the biosciences : CABIOS, 1995 Apr, Volume 11, Issue 2, p.187-94, (1995) Abstract
Working on the assembly line., Gibbs, R. A., and Cockerill M. , Trends in biochemical sciences, 1995 Apr, Volume 20, Issue 4, p.162-3, (1995)
130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus., Timms, K. M., Lu F., Shen Y., Pierson C. A., Muzny D. M., Gu Y., Nelson D. L., and Gibbs R. A. , Genome research, 1995 Aug, Volume 5, Issue 1, p.71-8, (1995) Abstract
Analysis of human immunodeficiency virus type 1 integrase mutants., Ansari-Lari, M. A., Donehower L. A., and Gibbs R. A. , Virology, 1995 Aug 1, Volume 211, Issue 1, p.332-5, (1995) Abstract
Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci., Oeltjen, J. C., Liu X., Lu J., Allen R. C., Muzny D., Belmont J. W., and Gibbs R. A. , Mammalian genome : official journal of the International Mammalian Genome Society, 1995 May, Volume 6, Issue 5, p.334-8, (1995) Abstract
Pressing ahead with human genome sequencing., Gibbs, R. A. , Nature genetics, 1995 Oct, Volume 11, Issue 2, p.121-5, (1995) Abstract
Fine structure of the human FMR1 gene., Eichler, E. E., Richards S., Gibbs R. A., and Nelson D. L. , Human molecular genetics, 1994 Apr, Volume 3, Issue 4, p.684-5, (1994)
Multiplex PCR: advantages, development, and applications., Edwards, M. C., and Gibbs R. A. , PCR methods and applications, 1994 Feb, Volume 3, Issue 4, p.S65-75, (1994)
Adaptor-based uracil DNA glycosylase cloning simplifies shotgun library construction for large-scale sequencing., Andersson, B., Povinelli C. M., Wentland M. A., Shen Y., Muzny D. M., and Gibbs R. A. , Analytical biochemistry, 1994 May 1, Volume 218, Issue 2, p.300-8, (1994) Abstract
A novel beta-thalassaemia mutation in the 5' untranslated region of the beta-globin gene., Athanassiadou, A., Papachatzopoulou A., Zoumbos N., Maniatis G. M., and Gibbs R. , British journal of haematology, 1994 Oct, Volume 88, Issue 2, p.307-10, (1994) Abstract
Termination of DNA synthesis by novel 3'-modified-deoxyribonucleoside 5'-triphosphates., Metzker, M. L., Raghavachari R., Richards S., Jacutin S. E., Civitello A., Burgess K., and Gibbs R. A. , Nucleic acids research, 1994 Oct 11, Volume 22, Issue 20, p.4259-67, (1994) Abstract
Analysis of HIV type 1 reverse transcriptase expression in a human cell line., Ansari-Lari, M. A., and Gibbs R. A. , AIDS research and human retroviruses, 1994 Sep, Volume 10, Issue 9, p.1117-24, (1994) Abstract
Detection and significance of HIV sequences in HIV infection., Lewis, D. E., and Gibbs R. A. , Progress in medical virology. Fortschritte der medizinischen Virusforschung. Progrès en virologie médicale, 1993, Volume 40, p.19-47, (1993)
Large-scale sequencing library production: an adaptor-based strategy., Povinelli, C. M., and Gibbs R. A. , Analytical biochemistry, 1993 Apr, Volume 210, Issue 1, p.16-26, (1993) Abstract
Decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy., Fu, Y. H., Friedman D. L., Richards S., Pearlman J. A., Gibbs R. A., Pizzuti A., Ashizawa T., Perryman M. B., Scarlato G., and Fenwick R. G. , Science (New York, N.Y.), 1993 Apr 9, Volume 260, Issue 5105, p.235-8, (1993) Abstract
Fine structure of the human FMR1 gene., Eichler, E. E., Richards S., Gibbs R. A., and Nelson D. L. , Human molecular genetics, 1993 Aug, Volume 2, Issue 8, p.1147-53, (1993) Abstract
Multiplex DNA amplification and solid-phase direct sequencing for mutation analysis at the hprt locus in Chinese hamster cells., Zu, Z., Yu Y., Gibbs R. A., Caskey C. T., and Hsie A. W. , Mutation research, 1993 Aug, Volume 288, Issue 2, p.237-48, (1993) Abstract
Rapid characterization of HIV-1 sequence diversity using denaturing gradient gel electrophoresis and direct automated DNA sequencing of PCR products., Andersson, B., Ying J. H., Lewis D. E., and Gibbs R. A. , PCR methods and applications, 1993 May, Volume 2, Issue 4, p.293-300, (1993) Abstract


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