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Richard Gibbs, Ph.D.

Director, Baylor College of Medicine Human Genome Sequencing Center

image: Richard Gibbs, Ph.D.Contact information

agibbs@bcm.edu

Other positions

Wofford Cain Chair in Molecular and Human Genetics

Professor, Department of Molecular and Human Genetics

Professor, Programs in Integrative Molecular and Biomedical Sciences and Translational Biology & Molecular Medicine

Education

B.Sc., University of Melbourne, 1979

Ph.D., University of Melbourne, 1985

Postdoc, Baylor College of Medicine, 1990

Awards and honors

2011: Elected to membership in the Institute of Medicine

2001: LSU Chancellor's Distinguished Lectureship

2000: Michael E. DeBakey, M.D., Excellence in Research Award

1988-1989: George R. Sampson Distinguished Research Fellowship, Muscular Dystrophy Association

1987: American Arthritis Foundation, Postdoctoral Fellowship

1986: Muscular Dystrophy Association of America, Postdoctoral Fellowship

Research interests

Richard Gibbs is the Founder and Director of the BCM-HGSC, established at BCM in 1996. The BCM-HGSC has a core mission of advancing medical care through research and translation of genomics. The group was one of the five worldwide sites to undertake and complete the Human Genome Project, culminating in contribution of approximately ten percent of the sequence in 2003. The group subsequently collaborated to sequence many key species (Drosophila melanogaster, the Brown Norway rat, rhesus macaque, bovine, Dictyostelium discoideum, sea urchin and honey bee genomes) and to generate the first comprehensive map of human genetic variation (the HapMap project). The BCM-HGSC now employs more than 180 staff, including eighteen faculty.

Since 2007, new technologies have allowed unprecedented advances in human genetics. The BCM-HGSC pioneered whole exome capture methods and published the first diploid sequence of a human, James Watson. Next we demonstrated the utility of whole genome sequencing for genetic disease discovery and for guiding effective clinical treatments. In 2011, we began deploying these methods into routine clinical practice and now provide full gene sequencing to hundreds of individual patients each month.

Current research within the BCM-HGSC is focused upon the genomics of cancer, heart disease and autism. To achieve this the group is sequencing single human genomes at an increasing rate. New molecular technologies are being developed for the mapping and sequencing, for exploring novel chemistries for DNA tagging, and to enable development of instrumentation for DNA manipulation. The HGSC is also part of the national program for systematic discovery of the cause of human single genome defects and has an active bioinformatics program, with research projects involving biologists and computer scientists. Problems under study focus on developing tools for generating, manipulating, and analyzing genome data.

Publications

Demographic history and rare allele sharing among human populations., Gravel, Simon, Henn Brenna M., Gutenkunst Ryan N., Indap Amit R., Marth Gabor T., Clark Andrew G., Yu Fuli, Gibbs Richard A., and Bustamante Carlos D. , Proceedings of the National Academy of Sciences of the United States of America, 2011 Jul 19, Volume 108, Issue 29, p.11983-8, (2011) Abstract
Whole-genome sequencing for optimized patient management., Bainbridge, Matthew N., Wiszniewski Wojciech, Murdock David R., Friedman Jennifer, Gonzaga-Jauregui Claudia, Newsham Irene, Reid Jeffrey G., Fink John K., Morgan Margaret B., Gingras Marie-Claude, et al. , Science translational medicine, 2011 Jun 15, Volume 3, Issue 87, p.87re3, (2011) Abstract
Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy., Klassen, Tara, Davis Caleb F., Goldman Alica, Burgess Dan, Chen Tim, Wheeler David, McPherson John, Bourquin Traci, Lewis Lora, Villasana Donna, et al. , Cell, 2011 Jun 24, Volume 145, Issue 7, p.1036-48, (2011) Abstract
TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum., Davis, Erica E., Zhang Qi, Liu Qin, Diplas Bill H., Davey Lisa M., Hartley Jane, Stoetzel Corinne, Szymanska Katarzyna, Ramaswami Gokul, Logan Clare V., et al. , Nature genetics, 2011 Mar, Volume 43, Issue 3, p.189-96, (2011) Abstract
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase., Sun, Tingting, Aceto Nicola, Meerbrey Kristen L., Kessler Jessica D., Zhou Chunshui, Migliaccio Ilenia, Nguyen Don X., Pavlova Natalya N., Botero Maria, Huang Jian, et al. , Cell, 2011 Mar 4, Volume 144, Issue 5, p.703-18, (2011) Abstract
Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications., Yilmaz, Pelin, Kottmann Renzo, Field Dawn, Knight Rob, Cole James R., Amaral-Zettler Linda, Gilbert Jack A., Karsch-Mizrachi Ilene, Johnston Anjanette, Cochrane Guy, et al. , Nature biotechnology, 2011 May, Volume 29, Issue 5, p.415-20, (2011) Abstract
Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome., Saulnier, Delphine M., Riehle Kevin, Mistretta Toni-Ann, Diaz Maria-Alejandra, Mandal Debasmita, Raza Sabeen, Weidler Erica M., Qin Xiang, Coarfa Cristian, Milosavljevic Aleksandar, et al. , Gastroenterology, 2011 Nov, Volume 141, Issue 5, p.1782-91, (2011) Abstract
Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer., Sano, Daisuke, Xie Tong-Xin, Ow Thomas J., Zhao Mei, Pickering Curtis R., Zhou Ge, Sandulache Vlad C., Wheeler David A., Gibbs Richard A., Caulin Carlos, et al. , Clinical cancer research : an official journal of the American Association for Cancer Research, 2011 Nov 1, Volume 17, Issue 21, p.6658-70, (2011) Abstract
Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion., Xi, Ruibin, Hadjipanayis Angela G., Luquette Lovelace J., Kim Tae-Min, Lee Eunjung, Zhang Jianhua, Johnson Mark D., Muzny Donna M., Wheeler David A., Gibbs Richard A., et al. , Proceedings of the National Academy of Sciences of the United States of America, 2011 Nov 15, Volume 108, Issue 46, p.E1128-36, (2011) Abstract
A high-resolution map of human evolutionary constraint using 29 mammals., Lindblad-Toh, Kerstin, Garber Manuel, Zuk Or, Lin Michael F., Parker Brian J., Washietl Stefan, Kheradpour Pouya, Ernst Jason, Jordan Gregory, Mauceli Evan, et al. , Nature, 2011 Oct 27, Volume 478, Issue 7370, p.476-82, (2011) Abstract
Whole-exome sequencing identifies compound heterozygous mutations in WDR62 in siblings with recurrent polymicrogyria., Murdock, David R., Clark Gary D., Bainbridge Matthew N., Newsham Irene, Wu Yuan-Qing, Muzny Donna M., Cheung Sau Wai, Gibbs Richard A., and Ramocki Melissa B. , American journal of medical genetics. Part A, 2011 Sep, Volume 155A, Issue 9, p.2071-7, (2011) Abstract
Oligogenic heterozygosity in individuals with high-functioning autism spectrum disorders., Schaaf, Christian P., Sabo Aniko, Sakai Yasunari, Crosby Jacy, Muzny Donna, Hawes Alicia, Lewis Lora, Akbar Humeira, Varghese Robin, Boerwinkle Eric, et al. , Human molecular genetics, 2011 Sep 1, Volume 20, Issue 17, p.3366-75, (2011) Abstract
Resequencing of IRS2 reveals rare variants for obesity but not fasting glucose homeostasis in Hispanic children., Butte, Nancy F., Voruganti Saroja V., Cole Shelley A., Haack Karin, Comuzzie Anthony G., Muzny Donna M., Wheeler David A., Chang Kyle, Hawes Alicia, and Gibbs Richard A. , Physiological genomics, 2011 Sep 22, Volume 43, Issue 18, p.1029-37, (2011) Abstract
Clan genomics and the complex architecture of human disease., Lupski, James R., Belmont John W., Boerwinkle Eric, and Gibbs Richard A. , Cell, 2011 Sep 30, Volume 147, Issue 1, p.32-43, (2011) Abstract
Deep resequencing reveals excess rare recent variants consistent with explosive population growth., Coventry, Alex, Bull-Otterson Lara M., Liu Xiaoming, Clark Andrew G., Maxwell Taylor J., Crosby Jacy, Hixson James E., Rea Thomas J., Muzny Donna M., Lewis Lora R., et al. , Nature communications, 2010, Volume 1, p.131, (2010) Abstract
Genetic diversity in India and the inference of Eurasian population expansion., Xing, Jinchuan, Watkins Scott W., Hu Ya, Huff Chad D., Sabo Aniko, Muzny Donna M., Bamshad Michael J., Gibbs Richard A., Jorde Lynn B., and Yu Fuli , Genome biology, 2010, Volume 11, Issue 11, p.R113, (2010) Abstract
Comparative genomics of Gardnerella vaginalis strains reveals substantial differences in metabolic and virulence potential., Yeoman, Carl J., Yildirim Suleyman, Thomas Susan M., Durkin Scott A., Torralba Manolito, Sutton Granger, Buhay Christian J., Ding Yan, Dugan-Rocha Shannon P., Muzny Donna M., et al. , PloS one, 2010, Volume 5, Issue 8, p.e12411, (2010) Abstract
Whole exome capture in solution with 3 Gbp of data., Bainbridge, Matthew N., Wang Min, Burgess Daniel L., Kovar Christie, Rodesch Matthew J., D'Ascenzo Mark, Kitzman Jacob, Wu Yuan-Qing, Newsham Irene, Richmond Todd A., et al. , Genome biology, 2010, Volume 11, Issue 6, p.R62, (2010) Abstract
Whole-genome sequencing in a patient with Charcot-Marie-Tooth neuropathy., Lupski, James R., Reid Jeffrey G., Gonzaga-Jauregui Claudia, Rio Deiros David, Chen David C. Y., Nazareth Lynne, Bainbridge Matthew, Dinh Huyen, Jing Chyn, Wheeler David A., et al. , The New England journal of medicine, 2010 Apr 1, Volume 362, Issue 13, p.1181-91, (2010) Abstract
A SNP discovery method to assess variant allele probability from next-generation resequencing data., Shen, Yufeng, Wan Zhengzheng, Coarfa Cristian, Drabek Rafal, Chen Lei, Ostrowski Elizabeth A., Liu Yue, Weinstock George M., Wheeler David A., Gibbs Richard A., et al. , Genome research, 2010 Feb, Volume 20, Issue 2, p.273-80, (2010) Abstract
Complete Khoisan and Bantu genomes from southern Africa., Schuster, Stephan C., Miller Webb, Ratan Aakrosh, Tomsho Lynn P., Giardine Belinda, Kasson Lindsay R., Harris Robert S., Petersen Desiree C., Zhao Fangqing, Qi Ji, et al. , Nature, 2010 Feb 18, Volume 463, Issue 7283, p.943-7, (2010) Abstract
Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children., Cole, Shelley A., Butte Nancy F., Voruganti Saroja V., Cai Guowen, Haack Karin, Kent Jack W., Blangero John, Comuzzie Anthony G., McPherson John D., and Gibbs Richard A. , The American journal of clinical nutrition, 2010 Jan, Volume 91, Issue 1, p.191-9, (2010) Abstract
Functional and evolutionary insights from the genomes of three parasitoid Nasonia species., Werren, John H., Richards Stephen, Desjardins Christopher A., Niehuis Oliver, Gadau Jürgen, Colbourne John K., Werren John H., Richards Stephen, Desjardins Christopher A., Niehuis Oliver, et al. , Science (New York, N.Y.), 2010 Jan 15, Volume 327, Issue 5963, p.343-8, (2010) Abstract
Genetics: Decoding a national treasure., Worley, Kim C., and Gibbs Richard A. , Nature, 2010 Jan 21, Volume 463, Issue 7279, p.303-4, (2010)
Rapid identification of heterozygous mutations in Drosophila melanogaster using genomic capture sequencing., Wang, Hui, Chattopadhyay Abanti, Li Zhe, Daines Bryce, Li Yumei, Gao Chunxu, Gibbs Richard, Zhang Kun, and Chen Rui , Genome research, 2010 Jul, Volume 20, Issue 7, p.981-8, (2010) Abstract


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