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Richard Gibbs, Ph.D.

Director, Baylor College of Medicine Human Genome Sequencing Center

image: Richard Gibbs, Ph.D.Contact information

agibbs@bcm.edu

Other positions

Wofford Cain Chair in Molecular and Human Genetics

Professor, Department of Molecular and Human Genetics

Professor, Programs in Integrative Molecular and Biomedical Sciences and Translational Biology & Molecular Medicine

Education

B.Sc., University of Melbourne, 1979

Ph.D., University of Melbourne, 1985

Postdoc, Baylor College of Medicine, 1990

Awards and honors

2011: Elected to membership in the Institute of Medicine

2001: LSU Chancellor's Distinguished Lectureship

2000: Michael E. DeBakey, M.D., Excellence in Research Award

1988-1989: George R. Sampson Distinguished Research Fellowship, Muscular Dystrophy Association

1987: American Arthritis Foundation, Postdoctoral Fellowship

1986: Muscular Dystrophy Association of America, Postdoctoral Fellowship

Research interests

Richard Gibbs is the Founder and Director of the BCM-HGSC, established at BCM in 1996. The BCM-HGSC has a core mission of advancing medical care through research and translation of genomics. The group was one of the five worldwide sites to undertake and complete the Human Genome Project, culminating in contribution of approximately ten percent of the sequence in 2003. The group subsequently collaborated to sequence many key species (Drosophila melanogaster, the Brown Norway rat, rhesus macaque, bovine, Dictyostelium discoideum, sea urchin and honey bee genomes) and to generate the first comprehensive map of human genetic variation (the HapMap project). The BCM-HGSC now employs more than 180 staff, including eighteen faculty.

Since 2007, new technologies have allowed unprecedented advances in human genetics. The BCM-HGSC pioneered whole exome capture methods and published the first diploid sequence of a human, James Watson. Next we demonstrated the utility of whole genome sequencing for genetic disease discovery and for guiding effective clinical treatments. In 2011, we began deploying these methods into routine clinical practice and now provide full gene sequencing to hundreds of individual patients each month.

Current research within the BCM-HGSC is focused upon the genomics of cancer, heart disease and autism. To achieve this the group is sequencing single human genomes at an increasing rate. New molecular technologies are being developed for the mapping and sequencing, for exploring novel chemistries for DNA tagging, and to enable development of instrumentation for DNA manipulation. The HGSC is also part of the national program for systematic discovery of the cause of human single genome defects and has an active bioinformatics program, with research projects involving biologists and computer scientists. Problems under study focus on developing tools for generating, manipulating, and analyzing genome data.

Publications

Whole-genome sequencing in a patient with Charcot-Marie-Tooth neuropathy., Lupski, James R., Reid Jeffrey G., Gonzaga-Jauregui Claudia, Rio Deiros David, Chen David C. Y., Nazareth Lynne, Bainbridge Matthew, Dinh Huyen, Jing Chyn, Wheeler David A., et al. , The New England journal of medicine, 2010 Apr 1, Volume 362, Issue 13, p.1181-91, (2010) Abstract
A SNP discovery method to assess variant allele probability from next-generation resequencing data., Shen, Yufeng, Wan Zhengzheng, Coarfa Cristian, Drabek Rafal, Chen Lei, Ostrowski Elizabeth A., Liu Yue, Weinstock George M., Wheeler David A., Gibbs Richard A., et al. , Genome research, 2010 Feb, Volume 20, Issue 2, p.273-80, (2010) Abstract
Complete Khoisan and Bantu genomes from southern Africa., Schuster, Stephan C., Miller Webb, Ratan Aakrosh, Tomsho Lynn P., Giardine Belinda, Kasson Lindsay R., Harris Robert S., Petersen Desiree C., Zhao Fangqing, Qi Ji, et al. , Nature, 2010 Feb 18, Volume 463, Issue 7283, p.943-7, (2010) Abstract
Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children., Cole, Shelley A., Butte Nancy F., Voruganti Saroja V., Cai Guowen, Haack Karin, Kent Jack W., Blangero John, Comuzzie Anthony G., McPherson John D., and Gibbs Richard A. , The American journal of clinical nutrition, 2010 Jan, Volume 91, Issue 1, p.191-9, (2010) Abstract
Functional and evolutionary insights from the genomes of three parasitoid Nasonia species., Werren, John H., Richards Stephen, Desjardins Christopher A., Niehuis Oliver, Gadau Jürgen, Colbourne John K., Werren John H., Richards Stephen, Desjardins Christopher A., Niehuis Oliver, et al. , Science (New York, N.Y.), 2010 Jan 15, Volume 327, Issue 5963, p.343-8, (2010) Abstract
Genetics: Decoding a national treasure., Worley, Kim C., and Gibbs Richard A. , Nature, 2010 Jan 21, Volume 463, Issue 7279, p.303-4, (2010)
Rapid identification of heterozygous mutations in Drosophila melanogaster using genomic capture sequencing., Wang, Hui, Chattopadhyay Abanti, Li Zhe, Daines Bryce, Li Yumei, Gao Chunxu, Gibbs Richard, Zhang Kun, and Chen Rui , Genome research, 2010 Jul, Volume 20, Issue 7, p.981-8, (2010) Abstract
A full-length cDNA resource for the pea aphid, Acyrthosiphon pisum., Shigenobu, S., Richards S., Cree A. G., Morioka M., Fukatsu T., Kudo T., Miyagishima S., Gibbs R. A., Stern D. L., and Nakabachi A. , Insect molecular biology, 2010 Mar, Volume 19 Suppl 2, p.23-31, (2010) Abstract
Taking DNA from the dead., McGuire, Amy L., Majumder Mary A., Halpern Scott D., Swindell J. S., Yaeger Laura V., Gibbs Richard A., and Wheeler Thomas M. , Nature reviews. Genetics, 2010 May, Volume 11, Issue 5, p.318, (2010)
A catalog of reference genomes from the human microbiome., Nelson, Karen E., Weinstock George M., Highlander Sarah K., Worley Kim C., Creasy Heather Huot, Wortman Jennifer Russo, Rusch Douglas B., Mitreva Makedonka, Sodergren Erica, Chinwalla Asif T., et al. , Science (New York, N.Y.), 2010 May 21, Volume 328, Issue 5981, p.994-9, (2010) Abstract
A map of human genome variation from population-scale sequencing., Abecasis, Gonçalo R., Altshuler David, Auton Adam, Brooks Lisa D., Durbin Richard M., Gibbs Richard A., Hurles Matt E., and McVean Gil A. , Nature, 2010 Oct 28, Volume 467, Issue 7319, p.1061-73, (2010) Abstract
Integrating common and rare genetic variation in diverse human populations., Altshuler, David M., Gibbs Richard A., Peltonen Leena, Altshuler David M., Gibbs Richard A., Peltonen Leena, Dermitzakis Emmanouil, Schaffner Stephen F., Yu Fuli, Peltonen Leena, et al. , Nature, 2010 Sep 2, Volume 467, Issue 7311, p.52-8, (2010) Abstract
Bos taurus genome assembly., Liu, Yue, Qin Xiang, Song Xing-Zhi Henry, Jiang Huaiyang, Shen Yufeng, Durbin James K., Lien Sigbjørn, Kent Matthew Peter, Sodeland Marte, Ren Yanru, et al. , BMC genomics, 2009, Volume 10, p.180, (2009) Abstract
Basic principles and technologies for deciphering the genetic map of cancer., Voidonikolas, Georgios, Kreml Stephanie S., Chen Changyi, Fisher William E., Brunicardi Charles F., Gibbs Richard A., and Gingras Marie-Claude , World journal of surgery, 2009 Apr, Volume 33, Issue 4, p.615-29, (2009) Abstract
Sequencing the full-length of the phosphatase and tensin homolog (PTEN) gene in hepatocellular carcinoma (HCC) using the 454 GS20 and Illumina GA DNA sequencing platforms., Rodriguez, Joel A., Guiteau Jacfranz J., Nazareth Lynne, Reid Jeff G., Goss John A., Gibbs Richard A., and Gingras Marie-Claude , World journal of surgery, 2009 Apr, Volume 33, Issue 4, p.647-52, (2009) Abstract
Microarray analysis of somatostatin receptor 5-regulated gene expression profiles in murine pancreas., Patel, Sanjeet G., Zhou Guisheng, Liu Shi-He, Li Min, Jeong Jae-Wook, DeMayo Francesco J., Gingras Marie-Claude, Gibbs Richard A., Fisher William E., and Brunicardi Charles F. , World journal of surgery, 2009 Apr, Volume 33, Issue 4, p.630-7, (2009) Abstract
Developing a tissue resource to characterize the genome of pancreatic cancer., Voidonikolas, Georgios, Gingras Marie-Claude, Hodges Sally, McGuire Amy L., Chen Changyi, Gibbs Richard A., Brunicardi Charles F., and Fisher William E. , World journal of surgery, 2009 Apr, Volume 33, Issue 4, p.723-31, (2009) Abstract
The genome sequence of taurine cattle: a window to ruminant biology and evolution., Elsik, Christine G., Tellam Ross L., Worley Kim C., Gibbs Richard A., Muzny Donna M., Weinstock George M., Adelson David L., Eichler Evan E., Elnitski Laura, Guigó Roderic, et al. , Science (New York, N.Y.), 2009 Apr 24, Volume 324, Issue 5926, p.522-8, (2009) Abstract
The genome sequence of taurine cattle: a window to ruminant biology and evolution., Elsik, Christine G., Tellam Ross L., Worley Kim C., Gibbs Richard A., Muzny Donna M., Weinstock George M., Adelson David L., Eichler Evan E., Elnitski Laura, Guigó Roderic, et al. , Science (New York, N.Y.), 2009 Apr 24, Volume 324, Issue 5926, p.522-8, (2009) Abstract
Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds., Gibbs, Richard A., Taylor Jeremy F., Van Tassell Curtis P., Barendse William, Eversole Kellye A., Gill Clare A., Green Ronnie D., Hamernik Debora L., Kappes Steven M., Lien Sigbjørn, et al. , Science (New York, N.Y.), 2009 Apr 24, Volume 324, Issue 5926, p.528-32, (2009) Abstract
High-throughput multiplex sequencing to discover copy number variants in Drosophila., Daines, Bryce, Wang Hui, Li Yumei, Han Yi, Gibbs Richard, and Chen Rui , Genetics, 2009 Aug, Volume 182, Issue 4, p.935-41, (2009) Abstract
Single nucleotide polymorphism in RECQL and survival in resectable pancreatic adenocarcinoma., Cotton, Ronald T., Li Donghui, Scherer Steven E., Muzny Donna M., Hodges Sally E., Catania Robbi L., Witkiewicz Agnieszka K., Brody Jonathan R., Kennedy Eugene P., Yeo Charles J., et al. , HPB : the official journal of the International Hepato Pancreato Biliary Association, 2009 Aug, Volume 11, Issue 5, p.435-44, (2009) Abstract
The completion of the Mammalian Gene Collection (MGC)., Temple, Gary, Gerhard Daniela S., Rasooly Rebekah, Feingold Elise A., Good Peter J., Robinson Cristen, Mandich Allison, Derge Jeffrey G., Lewis Jeanne, Shoaf Debonny, et al. , Genome research, 2009 Dec, Volume 19, Issue 12, p.2324-33, (2009) Abstract
A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome., Hampton, Oliver A., Den Hollander Petra, Miller Christopher A., Delgado David A., Li Jian, Coarfa Cristian, Harris Ronald A., Richards Stephen, Scherer Steven E., Muzny Donna M., et al. , Genome research, 2009 Feb, Volume 19, Issue 2, p.167-77, (2009) Abstract
A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies., Khanna, Hemant, Davis Erica E., Murga-Zamalloa Carlos A., Estrada-Cuzcano Alejandro, Lopez Irma, den Hollander Anneke I., Zonneveld Marijke N., Othman Mohammad I., Waseem Naushin, Chakarova Christina F., et al. , Nature genetics, 2009 Jun, Volume 41, Issue 6, p.739-45, (2009) Abstract


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