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Richard Gibbs, Ph.D.

Director, Baylor College of Medicine Human Genome Sequencing Center

image: Richard Gibbs, Ph.D.Contact information

Other positions

Wofford Cain Chair in Molecular and Human Genetics

Professor, Department of Molecular and Human Genetics

Professor, Programs in Integrative Molecular and Biomedical Sciences and Translational Biology & Molecular Medicine


B.Sc., University of Melbourne, 1979

Ph.D., University of Melbourne, 1985

Postdoc, Baylor College of Medicine, 1990

Awards and honors

2011: Elected to membership in the Institute of Medicine

2001: LSU Chancellor's Distinguished Lectureship

2000: Michael E. DeBakey, M.D., Excellence in Research Award

1988-1989: George R. Sampson Distinguished Research Fellowship, Muscular Dystrophy Association

1987: American Arthritis Foundation, Postdoctoral Fellowship

1986: Muscular Dystrophy Association of America, Postdoctoral Fellowship

Research interests

Richard Gibbs is the Founder and Director of the BCM-HGSC, established at BCM in 1996. The BCM-HGSC has a core mission of advancing medical care through research and translation of genomics. The group was one of the five worldwide sites to undertake and complete the Human Genome Project, culminating in contribution of approximately ten percent of the sequence in 2003. The group subsequently collaborated to sequence many key species (Drosophila melanogaster, the Brown Norway rat, rhesus macaque, bovine, Dictyostelium discoideum, sea urchin and honey bee genomes) and to generate the first comprehensive map of human genetic variation (the HapMap project). The BCM-HGSC now employs more than 180 staff, including eighteen faculty.

Since 2007, new technologies have allowed unprecedented advances in human genetics. The BCM-HGSC pioneered whole exome capture methods and published the first diploid sequence of a human, James Watson. Next we demonstrated the utility of whole genome sequencing for genetic disease discovery and for guiding effective clinical treatments. In 2011, we began deploying these methods into routine clinical practice and now provide full gene sequencing to hundreds of individual patients each month.

Current research within the BCM-HGSC is focused upon the genomics of cancer, heart disease and autism. To achieve this the group is sequencing single human genomes at an increasing rate. New molecular technologies are being developed for the mapping and sequencing, for exploring novel chemistries for DNA tagging, and to enable development of instrumentation for DNA manipulation. The HGSC is also part of the national program for systematic discovery of the cause of human single genome defects and has an active bioinformatics program, with research projects involving biologists and computer scientists. Problems under study focus on developing tools for generating, manipulating, and analyzing genome data.


A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome., Hampton, Oliver A., Den Hollander Petra, Miller Christopher A., Delgado David A., Li Jian, Coarfa Cristian, Harris Ronald A., Richards Stephen, Scherer Steven E., Muzny Donna M., et al. , Genome research, 2009 Feb, Volume 19, Issue 2, p.167-77, (2009) Abstract
A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies., Khanna, Hemant, Davis Erica E., Murga-Zamalloa Carlos A., Estrada-Cuzcano Alejandro, Lopez Irma, den Hollander Anneke I., Zonneveld Marijke N., Othman Mohammad I., Waseem Naushin, Chakarova Christina F., et al. , Nature genetics, 2009 Jun, Volume 41, Issue 6, p.739-45, (2009) Abstract
Low frequency of MLL3 mutations in colorectal carcinoma., Vakoc, Christopher R., Wen Yu-Ye, Gibbs Richard A., Johnstone Cameron N., Rustgi Anil K., and Blobel Gerd A. , Cancer genetics and cytogenetics, 2009 Mar, Volume 189, Issue 2, p.140-1, (2009)
Mutation survey of known LCA genes and loci in the Saudi Arabian population., Li, Yumei, Wang Hui, Peng Jianlan, Gibbs Richard A., Lewis Richard Alan, Lupski James R., Mardon Graeme, and Chen Rui , Investigative ophthalmology & visual science, 2009 Mar, Volume 50, Issue 3, p.1336-43, (2009) Abstract
Metagenomic pyrosequencing and microbial identification., Petrosino, Joseph F., Highlander Sarah, Luna Ruth Ann, Gibbs Richard A., and Versalovic James , Clinical chemistry, 2009 May, Volume 55, Issue 5, p.856-66, (2009) Abstract
A collagen-binding adhesin, Acb, and ten other putative MSCRAMM and pilus family proteins of Streptococcus gallolyticus subsp. gallolyticus (Streptococcus bovis Group, biotype I)., Sillanpää, Jouko, Nallapareddy Sreedhar R., Qin Xiang, Singh Kavindra V., Muzny Donna M., Kovar Christie L., Nazareth Lynne V., Gibbs Richard A., Ferraro Mary J., Steckelberg James M., et al. , Journal of bacteriology, 2009 Nov, Volume 191, Issue 21, p.6643-53, (2009) Abstract
Personalized copy number and segmental duplication maps using next-generation sequencing., Alkan, Can, Kidd Jeffrey M., Marques-Bonet Tomas, Aksay Gozde, Antonacci Francesca, Hormozdiari Fereydoun, Kitzman Jacob O., Baker Carl, Malig Maika, Mutlu Onur, et al. , Nature genetics, 2009 Oct, Volume 41, Issue 10, p.1061-7, (2009) Abstract
Common and rare variants of DAOA in bipolar disorder., Maheshwari, Manjula, Shi Jiajun, Badner Judith A., Skol Andrew, Willour Virginia L., Muzny Donna M., Wheeler David A., Gerald Fowler R., Detera-Wadleigh Sevilla, McMahon Francis J., et al. , American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2009 Oct 5, Volume 150B, Issue 7, p.960-6, (2009) Abstract
Genomics. Genome project standards in a new era of sequencing., Chain, P. S. G., Grafham D. V., Fulton R. S., Fitzgerald M. G., Hostetler J., Muzny D., Ali J., Birren B., Bruce D. C., Buhay C., et al. , Science (New York, N.Y.), 2009 Oct 9, Volume 326, Issue 5950, p.236-7, (2009)
Novel microRNA candidates and miRNA-mRNA pairs in embryonic stem (ES) cells., Gu, Peili, Reid Jeffrey G., Gao Xiaolian, Shaw Chad A., Creighton Chad, Tran Peter L., Zhou Xiaochuan, Drabek Rafal B., Steffen David L., Hoang David M., et al. , PloS one, 2008, Volume 3, Issue 7, p.e2548, (2008) Abstract
High-precision, whole-genome sequencing of laboratory strains facilitates genetic studies., Srivatsan, Anjana, Han Yi, Peng Jianlan, Tehranchi Ashley K., Gibbs Richard, Wang Jue D., and Chen Rui , PLoS genetics, 2008, Volume 4, Issue 8, p.e1000139, (2008) Abstract
Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF., Bourgogne, Agathe, Garsin Danielle A., Qin Xiang, Singh Kavindra V., Sillanpaa Jouko, Yerrapragada Shailaja, Ding Yan, Dugan-Rocha Shannon, Buhay Christian, Shen Hua, et al. , Genome biology, 2008, Volume 9, Issue 7, p.R110, (2008) Abstract
Analysis of transcriptome data in the red flour beetle, Tribolium castaneum., Park, Yoonseong, Aikins Jamie, Wang L. J., Beeman Richard W., Oppert Brenda, Lord Jeffrey C., Brown Susan J., Lorenzen Marcé D., Richards Stephen, Weinstock George M., et al. , Insect biochemistry and molecular biology, 2008 Apr, Volume 38, Issue 4, p.380-6, (2008) Abstract
The complete genome sequence of Escherichia coli DH10B: insights into the biology of a laboratory workhorse., Durfee, Tim, Nelson Richard, Baldwin Schuyler, Plunkett Guy, Burland Valerie, Mau Bob, Petrosino Joseph F., Qin Xiang, Muzny Donna M., Ayele Mulu, et al. , Journal of bacteriology, 2008 Apr, Volume 190, Issue 7, p.2597-606, (2008) Abstract
The complete genome of an individual by massively parallel DNA sequencing., Wheeler, David A., Srinivasan Maithreyan, Egholm Michael, Shen Yufeng, Chen Lei, McGuire Amy, He Wen, Chen Yi-Ju, Makhijani Vinod, Roth Thomas G., et al. , Nature, 2008 Apr 17, Volume 452, Issue 7189, p.872-6, (2008) Abstract
The genome of the model beetle and pest Tribolium castaneum., Richards, Stephen, Gibbs Richard A., Weinstock George M., Brown Susan J., Denell Robin, Beeman Richard W., Gibbs Richard, Beeman Richard W., Brown Susan J., Bucher Gregor, et al. , Nature, 2008 Apr 24, Volume 452, Issue 7190, p.949-55, (2008) Abstract
PDX-1 acts as a potential molecular target for treatment of human pancreatic cancer., Liu, Shihe, Ballian Nikiforos, Belaguli Narasimhaswamy S., Patel Sanjeet, Li Min, Templeton Nancy Smyth, Gingras Marie-Claude, Gibbs Richard, Fisher William, and Brunicardi Charles F. , Pancreas, 2008 Aug, Volume 37, Issue 2, p.210-20, (2008) Abstract
Rats in the genomic era., Worley, K. C., Weinstock G. M., and Gibbs R. A. , Physiological genomics, 2008 Feb 19, Volume 32, Issue 3, p.273-82, (2008) Abstract
What everybody should know about the rat genome and its online resources., Twigger, Simon N., Pruitt Kim D., Fernández-Suárez Xosé M., Karolchik Donna, Worley Kim C., Maglott Donna R., Brown Garth, Weinstock George, Gibbs Richard A., Kent Jim, et al. , Nature genetics, 2008 May, Volume 40, Issue 5, p.523-7, (2008) Abstract
Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1., Martinez-Moczygemba, Margarita, Doan Minh L., Elidemir Okan, Fan Leland L., Cheung Sau Wai, Lei Jonathan T., Moore James P., Tavana Ghamartaj, Lewis Lora R., Zhu Yiming, et al. , The Journal of experimental medicine, 2008 Nov 24, Volume 205, Issue 12, p.2711-6, (2008) Abstract
Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes., Reid, Jeffrey G., Nagaraja Ankur K., Lynn Francis C., Drabek Rafal B., Muzny Donna M., Shaw Chad A., Weiss Michelle K., Naghavi Arash O., Khan Mahjabeen, Zhu Huifeng, et al. , Genome research, 2008 Oct, Volume 18, Issue 10, p.1571-81, (2008) Abstract
Somatic mutations affect key pathways in lung adenocarcinoma., Ding, Li, Getz Gad, Wheeler David A., Mardis Elaine R., McLellan Michael D., Cibulskis Kristian, Sougnez Carrie, Greulich Heidi, Muzny Donna M., Morgan Margaret B., et al. , Nature, 2008 Oct 23, Volume 455, Issue 7216, p.1069-75, (2008) Abstract
Rats in the genomic era, Worley, K. C., Weinstock G. M., and Gibbs R. A. , Physiological Genomics, 11/2007, Volume 32, Issue 3, p.273 - 282, (2007)
The genome of Apis mellifera: dialog between linkage mapping and sequence assembly., Solignac, Michel, Zhang Lan, Mougel Florence, Li Bingshan, Vautrin Dominique, Monnerot Monique, Cornuet Jean-Marie, Worley Kim C., Weinstock George M., and Gibbs Richard A. , Genome biology, 2007, Volume 8, Issue 3, p.403, (2007) Abstract
Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques., Hernandez, Ryan D., Hubisz Melissa J., Wheeler David A., Smith David G., Ferguson Betsy, Rogers Jeffrey, Nazareth Lynne, Indap Amit, Bourquin Traci, McPherson John, et al. , Science (New York, N.Y.), 2007 Apr 13, Volume 316, Issue 5822, p.240-3, (2007) Abstract

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