Skip to Content

Richard Gibbs, Ph.D.

Director, Baylor College of Medicine Human Genome Sequencing Center

image: Richard Gibbs, Ph.D.Contact information

agibbs@bcm.edu

Other positions

Wofford Cain Chair in Molecular and Human Genetics

Professor, Department of Molecular and Human Genetics

Professor, Programs in Integrative Molecular and Biomedical Sciences and Translational Biology & Molecular Medicine

Education

B.Sc., University of Melbourne, 1979

Ph.D., University of Melbourne, 1985

Postdoc, Baylor College of Medicine, 1990

Awards and honors

2011: Elected to membership in the Institute of Medicine

2001: LSU Chancellor's Distinguished Lectureship

2000: Michael E. DeBakey, M.D., Excellence in Research Award

1988-1989: George R. Sampson Distinguished Research Fellowship, Muscular Dystrophy Association

1987: American Arthritis Foundation, Postdoctoral Fellowship

1986: Muscular Dystrophy Association of America, Postdoctoral Fellowship

Research interests

Richard Gibbs is the Founder and Director of the BCM-HGSC, established at BCM in 1996. The BCM-HGSC has a core mission of advancing medical care through research and translation of genomics. The group was one of the five worldwide sites to undertake and complete the Human Genome Project, culminating in contribution of approximately ten percent of the sequence in 2003. The group subsequently collaborated to sequence many key species (Drosophila melanogaster, the Brown Norway rat, rhesus macaque, bovine, Dictyostelium discoideum, sea urchin and honey bee genomes) and to generate the first comprehensive map of human genetic variation (the HapMap project). The BCM-HGSC now employs more than 180 staff, including eighteen faculty.

Since 2007, new technologies have allowed unprecedented advances in human genetics. The BCM-HGSC pioneered whole exome capture methods and published the first diploid sequence of a human, James Watson. Next we demonstrated the utility of whole genome sequencing for genetic disease discovery and for guiding effective clinical treatments. In 2011, we began deploying these methods into routine clinical practice and now provide full gene sequencing to hundreds of individual patients each month.

Current research within the BCM-HGSC is focused upon the genomics of cancer, heart disease and autism. To achieve this the group is sequencing single human genomes at an increasing rate. New molecular technologies are being developed for the mapping and sequencing, for exploring novel chemistries for DNA tagging, and to enable development of instrumentation for DNA manipulation. The HGSC is also part of the national program for systematic discovery of the cause of human single genome defects and has an active bioinformatics program, with research projects involving biologists and computer scientists. Problems under study focus on developing tools for generating, manipulating, and analyzing genome data.

Publications

Novel microRNA candidates and miRNA-mRNA pairs in embryonic stem (ES) cells., Gu, Peili, Reid Jeffrey G., Gao Xiaolian, Shaw Chad A., Creighton Chad, Tran Peter L., Zhou Xiaochuan, Drabek Rafal B., Steffen David L., Hoang David M., et al. , PloS one, 2008, Volume 3, Issue 7, p.e2548, (2008) Abstract
High-precision, whole-genome sequencing of laboratory strains facilitates genetic studies., Srivatsan, Anjana, Han Yi, Peng Jianlan, Tehranchi Ashley K., Gibbs Richard, Wang Jue D., and Chen Rui , PLoS genetics, 2008, Volume 4, Issue 8, p.e1000139, (2008) Abstract
Analysis of transcriptome data in the red flour beetle, Tribolium castaneum., Park, Yoonseong, Aikins Jamie, Wang L. J., Beeman Richard W., Oppert Brenda, Lord Jeffrey C., Brown Susan J., Lorenzen Marcé D., Richards Stephen, Weinstock George M., et al. , Insect biochemistry and molecular biology, 2008 Apr, Volume 38, Issue 4, p.380-6, (2008) Abstract
The complete genome sequence of Escherichia coli DH10B: insights into the biology of a laboratory workhorse., Durfee, Tim, Nelson Richard, Baldwin Schuyler, Plunkett Guy, Burland Valerie, Mau Bob, Petrosino Joseph F., Qin Xiang, Muzny Donna M., Ayele Mulu, et al. , Journal of bacteriology, 2008 Apr, Volume 190, Issue 7, p.2597-606, (2008) Abstract
The complete genome of an individual by massively parallel DNA sequencing., Wheeler, David A., Srinivasan Maithreyan, Egholm Michael, Shen Yufeng, Chen Lei, McGuire Amy, He Wen, Chen Yi-Ju, Makhijani Vinod, Roth Thomas G., et al. , Nature, 2008 Apr 17, Volume 452, Issue 7189, p.872-6, (2008) Abstract
The genome of the model beetle and pest Tribolium castaneum., Richards, Stephen, Gibbs Richard A., Weinstock George M., Brown Susan J., Denell Robin, Beeman Richard W., Gibbs Richard, Beeman Richard W., Brown Susan J., Bucher Gregor, et al. , Nature, 2008 Apr 24, Volume 452, Issue 7190, p.949-55, (2008) Abstract
PDX-1 acts as a potential molecular target for treatment of human pancreatic cancer., Liu, Shihe, Ballian Nikiforos, Belaguli Narasimhaswamy S., Patel Sanjeet, Li Min, Templeton Nancy Smyth, Gingras Marie-Claude, Gibbs Richard, Fisher William, and Brunicardi Charles F. , Pancreas, 2008 Aug, Volume 37, Issue 2, p.210-20, (2008) Abstract
Rats in the genomic era., Worley, K. C., Weinstock G. M., and Gibbs R. A. , Physiological genomics, 2008 Feb 19, Volume 32, Issue 3, p.273-82, (2008) Abstract
What everybody should know about the rat genome and its online resources., Twigger, Simon N., Pruitt Kim D., Fernández-Suárez Xosé M., Karolchik Donna, Worley Kim C., Maglott Donna R., Brown Garth, Weinstock George, Gibbs Richard A., Kent Jim, et al. , Nature genetics, 2008 May, Volume 40, Issue 5, p.523-7, (2008) Abstract
Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1., Martinez-Moczygemba, Margarita, Doan Minh L., Elidemir Okan, Fan Leland L., Cheung Sau Wai, Lei Jonathan T., Moore James P., Tavana Ghamartaj, Lewis Lora R., Zhu Yiming, et al. , The Journal of experimental medicine, 2008 Nov 24, Volume 205, Issue 12, p.2711-6, (2008) Abstract
Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes., Reid, Jeffrey G., Nagaraja Ankur K., Lynn Francis C., Drabek Rafal B., Muzny Donna M., Shaw Chad A., Weiss Michelle K., Naghavi Arash O., Khan Mahjabeen, Zhu Huifeng, et al. , Genome research, 2008 Oct, Volume 18, Issue 10, p.1571-81, (2008) Abstract
Somatic mutations affect key pathways in lung adenocarcinoma., Ding, Li, Getz Gad, Wheeler David A., Mardis Elaine R., McLellan Michael D., Cibulskis Kristian, Sougnez Carrie, Greulich Heidi, Muzny Donna M., Morgan Margaret B., et al. , Nature, 2008 Oct 23, Volume 455, Issue 7216, p.1069-75, (2008) Abstract
Rats in the genomic era, Worley, K. C., Weinstock G. M., and Gibbs R. A. , Physiological Genomics, 11/2007, Volume 32, Issue 3, p.273 - 282, (2007)
The genome of Apis mellifera: dialog between linkage mapping and sequence assembly., Solignac, Michel, Zhang Lan, Mougel Florence, Li Bingshan, Vautrin Dominique, Monnerot Monique, Cornuet Jean-Marie, Worley Kim C., Weinstock George M., and Gibbs Richard A. , Genome biology, 2007, Volume 8, Issue 3, p.403, (2007) Abstract
Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques., Hernandez, Ryan D., Hubisz Melissa J., Wheeler David A., Smith David G., Ferguson Betsy, Rogers Jeffrey, Nazareth Lynne, Indap Amit, Bourquin Traci, McPherson John, et al. , Science (New York, N.Y.), 2007 Apr 13, Volume 316, Issue 5822, p.240-3, (2007) Abstract
Evolutionary and biomedical insights from the rhesus macaque genome., Gibbs, Richard A., Rogers Jeffrey, Katze Michael G., Bumgarner Roger, Weinstock George M., Mardis Elaine R., Remington Karin A., Strausberg Robert L., Venter Craig J., Wilson Richard K., et al. , Science (New York, N.Y.), 2007 Apr 13, Volume 316, Issue 5822, p.222-34, (2007) Abstract
28-way vertebrate alignment and conservation track in the UCSC Genome Browser., Miller, Webb, Rosenbloom Kate, Hardison Ross C., Hou Minmei, Taylor James, Raney Brian, Burhans Richard, King David C., Baertsch Robert, Blankenberg Daniel, et al. , Genome research, 2007 Dec, Volume 17, Issue 12, p.1797-808, (2007) Abstract
Characterizing the cancer genome in lung adenocarcinoma., Weir, Barbara A., Woo Michele S., Getz Gad, Perner Sven, Ding Li, Beroukhim Rameen, Lin William M., Province Michael A., Kraja Aldi, Johnson Laura A., et al. , Nature, 2007 Dec 6, Volume 450, Issue 7171, p.893-8, (2007) Abstract
Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome., Margulies, Elliott H., Cooper Gregory M., Asimenos George, Thomas Daryl J., Dewey Colin N., Siepel Adam, Birney Ewan, Keefe Damian, Schwartz Ariel S., Hou Minmei, et al. , Genome research, 2007 Jun, Volume 17, Issue 6, p.760-74, (2007) Abstract
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project., Birney, Ewan, Stamatoyannopoulos John A., Dutta Anindya, Guigó Roderic, Gingeras Thomas R., Margulies Elliott H., Weng Zhiping, Snyder Michael, Dermitzakis Emmanouil T., Thurman Robert E., et al. , Nature, 2007 Jun 14, Volume 447, Issue 7146, p.799-816, (2007) Abstract
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project., Birney, Ewan, Stamatoyannopoulos John A., Dutta Anindya, Guigó Roderic, Gingeras Thomas R., Margulies Elliott H., Weng Zhiping, Snyder Michael, Dermitzakis Emmanouil T., Thurman Robert E., et al. , Nature, 2007 Jun 14, Volume 447, Issue 7146, p.799-816, (2007) Abstract
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project., Birney, Ewan, Stamatoyannopoulos John A., Dutta Anindya, Guigó Roderic, Gingeras Thomas R., Margulies Elliott H., Weng Zhiping, Snyder Michael, Dermitzakis Emmanouil T., Thurman Robert E., et al. , Nature, 2007 Jun 14, Volume 447, Issue 7146, p.799-816, (2007) Abstract
Direct selection of human genomic loci by microarray hybridization., Albert, Thomas J., Molla Michael N., Muzny Donna M., Nazareth Lynne, Wheeler David, Song Xingzhi, Richmond Todd A., Middle Chris M., Rodesch Matthew J., Packard Charles J., et al. , Nature methods, 2007 Nov, Volume 4, Issue 11, p.903-5, (2007) Abstract
Sequence variation in DOCK9 and heterogeneity in bipolar disorder., Detera-Wadleigh, Sevilla D., Liu Chun-yu, Maheshwari Manjula, Cardona Imer, Corona Winston, Akula Nirmala, Steele C. J. M., Badner Judith A., Kundu Mukta, Kassem Layla, et al. , Psychiatric genetics, 2007 Oct, Volume 17, Issue 5, p.274-86, (2007) Abstract
A second generation human haplotype map of over 3.1 million SNPs., Frazer, Kelly A., Ballinger Dennis G., Cox David R., Hinds David A., Stuve Laura L., Gibbs Richard A., Belmont John W., Boudreau Andrew, Hardenbol Paul, Leal Suzanne M., et al. , Nature, 2007 Oct 18, Volume 449, Issue 7164, p.851-61, (2007) Abstract


about seo | people