Skip to Content

Jeffrey Rogers, Ph.D.

Associate Professor, Department of Molecular and Human Genetics

image: Jeffrey Rogers, Ph.D.Contact information

jr13@bcm.edu

Other positions

Core Scientist, Wisconsin National Primate Research Center, Madison, WI

Education

B.A., Northwestern University, 1978

Ph.D., Anthropology, Yale University, 1989

Research interests

My research is focused on the genetics and genomics of nonhuman primates. These species are widely used as animal models of disease because they are so similar genetically and physiologically to humans. For studies of neurobiology and behavior, infectious diseases, metabolic diseases and other common health problems, nonhuman primates provide unique and valuable experimental models. As the impact of genetics on biomedical and basic biological research increases, the need for detailed information about the genomics of nonhuman primates also grows.

My laboratory is working on various aspects of primate genomics, including both basic comparative analyses and targeted research using primate models of human disease, with special emphasis on the genetics of brain function and risk factors for psychiatric disorders. As a member of the Baylor College of Medicine Human Genome Sequencing Center (BCM-HGSC), I help to plan and execute various studies of nonhuman primate genomes. Working with other BCM-HGSC faculty and staff, as well as people outside BCM, we are producing de novo whole genome assemblies for several primates, including baboons (Papio anubis), marmosets (Callithrix jacchus), gibbons (Nomascus leucogenys), mouse lemurs (Microcebus murinus), mangabeys (Cercocebus atys) and others. These projects involve deep whole genome sequencing of one individual per species, and computational assembly of the sequence data to produce a reference genome sequence that will be a resource for all future genetic analyses of that species. These projects include the sequencing of additional individuals to identify intra-species genetic variation and RNA sequencing to characterize gene expression. The result is high quality genomic information that facilitates both disease-related research and analyses of genome evolution. We recently began an extensive survey of genomic variation in the most widely used nonhuman primate, the rhesus macaque (Macaca mulatta). By sequencing greater than 100 rhesus monkeys from various research colonies we have discovered functionally significant genetic variation that can be used to examine the effects of specific genes on various disease-related phenotypes. Information regarding genetic variation, and other genomic data, makes all these primate species more useful for future biomedical research projects.

The second major line of research in my laboratory is the genetic analysis of nonhuman primate neurobiology and primate models of risk for psychiatric disease. In collaboration with psychiatrists and neurobiologists, we study individual variation in behavior among macaques and baboons, and the underlying neurobiological mechanisms. The multifaceted behavior of primates, including complex social interactions, makes them outstanding subjects for behavioral and neurogenetics. In one study, we are analyzing the genetics of individual variation among juvenile rhesus monkeys in response to a standardized test procedure, examining genetic effects on behavioral reactivity, brain metabolic activity measured by FDG-PET imaging and structural variation in neural circuits measured by DTI imaging. This project has generated novel information about the effects of specific genes on behavior and brain function that is directly related to the risk for anxiety disorders and depression among humans (Oler et al. 2010; Rogers et al. 2013). The primate models point us to genetic mechanisms that may influence susceptibility to psychiatric disorders in people. We are also analyzing brain structure in baboons (Kochunov et al. 2010; Rogers et al. 2010), behavioral reactivity and response to novelty in macaques, and the genetics of oxytocin and social interactions among adult female macaques.

While most of our effort is focused on the projects above, I also maintain an active interest in genetic analyses of wild primate populations. With several colleagues we are studying wild kinda baboons (Papio kindae) in Zambia (Jolly et al. 2011), a species only recently recognized as distinct from other baboons and which has received little formal scientific attention.

Publications

Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques., Hernandez, Ryan D., Hubisz Melissa J., Wheeler David A., Smith David G., Ferguson Betsy, Rogers Jeffrey, Nazareth Lynne, Indap Amit, Bourquin Traci, McPherson John, et al. , Science (New York, N.Y.), 2007 Apr 13, Volume 316, Issue 5822, p.240-3, (2007) Abstract
Heritability of brain volume, surface area and shape: an MRI study in an extended pedigree of baboons., Rogers, Jeffrey, Kochunov Peter, Lancaster Jack, Shelledy Wendy, Glahn David, Blangero John, and Fox Peter , Human brain mapping, 2007 Jun, Volume 28, Issue 6, p.576-83, (2007) Abstract
Quantitative trait loci for peripheral blood cell counts: a study in baboons., Bertin, Angéline, Mahaney Michael C., Cox Laura A., Rogers Jeffrey, VandeBerg John L., Brugnara Carlo, and Platt Orah S. , Mammalian genome : official journal of the International Mammalian Genome Society, 2007 May, Volume 18, Issue 5, p.361-72, (2007) Abstract
Trisomy 17 in a baboon (Papio hamadryas) with polydactyly, patent foramen ovale and pyelectasis., Moore, Charleen M., Hubbard Gene B., Dick Edward, Dunn Betty G., Raveendran Muthuswamy, Rogers Jeffrey, Williams Vick, Gomez Jeremiah J., Butler Stephanie D., Leland Michelle M., et al. , American journal of primatology, 2007 Oct, Volume 69, Issue 10, p.1105-18, (2007) Abstract
A preliminary study of the baboon prostate pathophysiology., Mubiru, James N., Hubbard Gene B., Dick Edward J., Butler Stephanie D., Valente Anthony J., Troyer Dean A., and Rogers Jeffrey , The Prostate, 2007 Sep 15, Volume 67, Issue 13, p.1421-31, (2007) Abstract
Designing new microsatellite markers for linkage and population genetic analyses in rhesus macaques and other nonhuman primates., Raveendran, Muthuswamy, Harris Alan R., Milosavljevic Aleksandar, Johnson Zach, Shelledy Wendy, Cameron Judy, and Rogers Jeffrey , Genomics, 2006 Dec, Volume 88, Issue 6, p.706-10, (2006) Abstract
Initial sequencing and analysis of the human genome., Lander, E. S., Linton L. M., Birren B., Nusbaum C., Zody M. C., Baldwin J., Devon K., Dewar K., Doyle M., FitzHugh W., et al. , Nature, 2001 Feb 15, Volume 409, Issue 6822, p.860-921, (2001) Abstract
A baboon (Papio hamadryas) with an isochromosome for the long arm of the X., Moore, C. M., Leland M. M., Brzyski R. G., McKeand J., Witte S. M., and Rogers J. , Cytogenetics and cell genetics, 1998, Volume 82, Issue 1-2, p.80-2, (1998) Abstract
Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic studies of bone mineral density., Rosen, C. J., Kurland E. S., Vereault D., Adler R. A., Rackoff P. J., Craig W. Y., Witte S., Rogers J., and Bilezikian J. P. , The Journal of clinical endocrinology and metabolism, 1998 Jul, Volume 83, Issue 7, p.2286-90, (1998) Abstract
Simian T-lymphotropic virus type 1 (STLV-1) infection in wild yellow baboons (Papio hamadryas cynocephalus) from Mikumi National Park, Tanzania., Voevodin, A., Samilchuk E., Allan J., Rogers J., and Broussard S. , Virology, 1997 Feb 17, Volume 228, Issue 2, p.350-9, (1997) Abstract
Beyond one gene-one disease: alternative strategies for deciphering genetic determinants of osteoporosis., Rogers, J., Mahaney M. C., Beamer W. G., Donahue L. R., and Rosen C. J. , Calcified tissue international, 1997 Mar, Volume 60, Issue 3, p.225-8, (1997)
Baboons as an animal model for genetic studies of common human disease., Rogers, J., and Hixson J. E. , American journal of human genetics, 1997 Sep, Volume 61, Issue 3, p.489-93, (1997)
Conservation of human chromosome 18 in baboons (Papio hamadryas): a linkage map of eight human microsatellites., Perelygin, A. A., Kammerer C. M., Stowell N. C., and Rogers J. , Cytogenetics and cell genetics, 1996, Volume 75, Issue 4, p.207-9, (1996) Abstract
Variability of dopamine D4 receptor (DRD4) gene sequence within and among nonhuman primate species., Livak, K. J., Rogers J., and Lichter J. B. , Proceedings of the National Academy of Sciences of the United States of America, 1995 Jan 17, Volume 92, Issue 2, p.427-31, (1995) Abstract
Linkage mapping in Papio baboons: conservation of a syntenic group of six markers on human chromosome 1., Rogers, J., Witte S. M., Kammerer C. M., Hixson J. E., and MacCluer J. W. , Genomics, 1995 Jul 20, Volume 28, Issue 2, p.251-4, (1995) Abstract
When is ancient polymorphism a potential problem for molecular phylogenetics?, Rogers, J., and Comuzzie A. G. , American journal of physical anthropology, 1995 Oct, Volume 98, Issue 2, p.216-8; discussion 224-8, (1995)
Infection of a yellow baboon with simian immunodeficiency virus from African green monkeys: evidence for cross-species transmission in the wild., Jin, M. J., Rogers J., Phillips-Conroy J. E., Allan J. S., Desrosiers R. C., Shaw G. M., Sharp P. M., and Hahn B. H. , Journal of virology, 1994 Dec, Volume 68, Issue 12, p.8454-60, (1994) Abstract
Levels of the genealogical hierarchy and the problem of hominoid phylogeny., Rogers, J. , American journal of physical anthropology, 1994 May, Volume 94, Issue 1, p.81-8, (1994) Abstract
Nuclear DNA polymorphisms in a wild population of yellow baboons (Papio hamadryas cynocephalus) from Mikumi National Park, Tanzania., Rogers, J., and Kidd K. K. , American journal of physical anthropology, 1993 Apr, Volume 90, Issue 4, p.477-86, (1993) Abstract


about seo | people