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Aniko Sabo, Ph.D.

Research Assistant Professor, Department of Molecular and Human Genetics

image: Aniko Sabo, Ph.D.Contact information


Ph.D., Purdue University, 2002

B.S., University of Novi Sad, Serbia, Yugoslavia, 1997

Research Interests

Aniko Sabo received her Ph.D. in the field of molecular phylogenetics from Purdue University in 2002 and has been doing research in the field of genomics for the last 12 years. She worked for three years as a Research Associate at the Genome Center at Washington University in St. Louis working on microbial and human annotation projects.

Since she joined the BCM-HGSC nine years ago, she has worked as a bioinformatics programmer and project manager and analysis lead for several projects.

She has extensive knowledge of capture methodology and the analysis of the next generation sequencing data.

Dr. Sabo has led the genome-level data analysis for several projects at the BCM-HGSC, including leading the validation efforts for several large-scale projects.

As the BCM-HGSC lead for the NIMH-funded Autism Genetics Project, she played a major role in the data analysis, development of initial genome variant lists, integration strategies for datasets from different sequencing and capture platforms, as well as interacting with collaborating groups and project investigators.

She has also been leading the analysis of exome sequencing data from atypical ciliopathy trios that resulted in discovery of several candidate genes that are currently undergoing functional validation follow-up.



Assessing structural variation in a personal genome-towards a human reference diploid genome., English, Adam C., Salerno William J., Hampton Oliver A., Gonzaga-Jauregui Claudia, Ambreth Shruthi, Ritter Deborah I., Beck Christine R., Davis Caleb F., Dahdouli Mahmoud, Ma Singer, et al. , BMC genomics, 2015 Apr 11, Volume 16, Issue 1, p.286, (2015) Abstract
Recurrent CNVs and SNVs at the NPHP1 Locus Contribute Pathogenic Alleles to Bardet-Biedl Syndrome, Lindstrand, Anna, Davis Erica E., Carvalho Claudia M.B., Pehlivan Davut, Willer Jason R., Tsai I-Chun, Ramanathan Subhadra, Zuppan Craig, Sabo Aniko, Muzny Donna, et al. , The American Journal of Human Genetics, 05/2014, Volume 94, Issue 5, p.745 - 754, (2014)
Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia., Sheehan, Vivien A., Crosby Jacy R., Sabo Aniko, Mortier Nicole A., Howard Thad A., Muzny Donna M., Dugan-Perez Shannon, Aygun Banu, Nottage Kerri A., Boerwinkle Eric, et al. , PloS one, 2014, Volume 9, Issue 10, p.e110740, (2014) Abstract
A framework for the interpretation of de novo mutation in human disease, Samocha, Kaitlin E., Robinson Elise B., Sanders Stephan J., Stevens Christine, Sabo Aniko, McGrath Lauren M., Kosmicki Jack A., Rehnström Karola, Mallick Swapan, Kirby Andrew, et al. , Nature Genetics, 8/2014, Volume 46, Issue 9, p.944 - 950, (2014)
Analysis of rare, exonic variation amongst subjects with autism spectrum disorders and population controls., Liu, Li, Sabo Aniko, Neale Benjamin M., Nagaswamy Uma, Stevens Christine, Lim Elaine, Bodea Corneliu A., Muzny Donna, Reid Jeffrey G., Banks Eric, et al. , PLoS genetics, 2013 Apr, Volume 9, Issue 4, p.e1003443, (2013) Abstract
Deep resequencing and association analysis of schizophrenia candidate genes., Crowley, J. J., Hilliard C. E., Kim Y., Morgan M. B., Lewis L. R., Muzny D. M., Hawes A. C., Sabo A., Wheeler D. A., Lieberman J. A., et al. , Molecular psychiatry, 2013 Feb, Volume 18, Issue 2, p.138-40, (2013)
Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders., Lim, Elaine T., Raychaudhuri Soumya, Sanders Stephan J., Stevens Christine, Sabo Aniko, MacArthur Daniel G., Neale Benjamin M., Kirby Andrew, Ruderfer Douglas M., Fromer Menachem, et al. , Neuron, 2013 Jan 23, Volume 77, Issue 2, p.235-42, (2013) Abstract
Patterns and rates of exonic de novo mutations in autism spectrum disorders., Neale, Benjamin M., Kou Yan, Liu Li, Ma'ayan Avi, Samocha Kaitlin E., Sabo Aniko, Lin Chiao-Feng, Stevens Christine, Wang Li-San, Makarov Vladimir, et al. , Nature, 2012 May 10, Volume 485, Issue 7397, p.242-5, (2012) Abstract
Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model., McIntyre, Jeremy C., Davis Erica E., Joiner Ariell, Williams Corey L., Tsai I-Chun, Jenkins Paul M., McEwen Dyke P., Zhang Lian, Escobado John, Thomas Sophie, et al. , Nature medicine, 2012 Sep, Volume 18, Issue 9, p.1423-8, (2012) Abstract
Oligogenic heterozygosity in individuals with high-functioning autism spectrum disorders., Schaaf, Christian P., Sabo Aniko, Sakai Yasunari, Crosby Jacy, Muzny Donna, Hawes Alicia, Lewis Lora, Akbar Humeira, Varghese Robin, Boerwinkle Eric, et al. , Human molecular genetics, 2011 Sep 1, Volume 20, Issue 17, p.3366-75, (2011) Abstract
Deep resequencing reveals excess rare recent variants consistent with explosive population growth., Coventry, Alex, Bull-Otterson Lara M., Liu Xiaoming, Clark Andrew G., Maxwell Taylor J., Crosby Jacy, Hixson James E., Rea Thomas J., Muzny Donna M., Lewis Lora R., et al. , Nature communications, 2010, Volume 1, p.131, (2010) Abstract
Genetic diversity in India and the inference of Eurasian population expansion., Xing, Jinchuan, Watkins Scott W., Hu Ya, Huff Chad D., Sabo Aniko, Muzny Donna M., Bamshad Michael J., Gibbs Richard A., Jorde Lynn B., and Yu Fuli , Genome biology, 2010, Volume 11, Issue 11, p.R113, (2010) Abstract
The genome sequence of taurine cattle: a window to ruminant biology and evolution., Elsik, Christine G., Tellam Ross L., Worley Kim C., Gibbs Richard A., Muzny Donna M., Weinstock George M., Adelson David L., Eichler Evan E., Elnitski Laura, Guigó Roderic, et al. , Science (New York, N.Y.), 2009 Apr 24, Volume 324, Issue 5926, p.522-8, (2009) Abstract
The genome sequence of taurine cattle: a window to ruminant biology and evolution., Elsik, Christine G., Tellam Ross L., Worley Kim C., Gibbs Richard A., Muzny Donna M., Weinstock George M., Adelson David L., Eichler Evan E., Elnitski Laura, Guigó Roderic, et al. , Science (New York, N.Y.), 2009 Apr 24, Volume 324, Issue 5926, p.522-8, (2009) Abstract
Somatic mutations affect key pathways in lung adenocarcinoma., Ding, Li, Getz Gad, Wheeler David A., Mardis Elaine R., McLellan Michael D., Cibulskis Kristian, Sougnez Carrie, Greulich Heidi, Muzny Donna M., Morgan Margaret B., et al. , Nature, 2008 Oct 23, Volume 455, Issue 7216, p.1069-75, (2008) Abstract
Evolutionary and biomedical insights from the rhesus macaque genome., Gibbs, Richard A., Rogers Jeffrey, Katze Michael G., Bumgarner Roger, Weinstock George M., Mardis Elaine R., Remington Karin A., Strausberg Robert L., Venter Craig J., Wilson Richard K., et al. , Science (New York, N.Y.), 2007 Apr 13, Volume 316, Issue 5822, p.222-34, (2007) Abstract
Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach., Chen, Swaine L., Hung Chia-Seui, Xu Jian, Reigstad Christopher S., Magrini Vincent, Sabo Aniko, Blasiar Darin, Bieri Tamberlyn, Meyer Rekha R., Ozersky Philip, et al. , Proceedings of the National Academy of Sciences of the United States of America, 2006 Apr 11, Volume 103, Issue 15, p.5977-82, (2006) Abstract
Generation and annotation of the DNA sequences of human chromosomes 2 and 4., Hillier, Ladeana W., Graves Tina A., Fulton Robert S., Fulton Lucinda A., Pepin Kymberlie H., Minx Patrick, Wagner-McPherson Caryn, Layman Dan, Wylie Kristine, Sekhon Mandeep, et al. , Nature, 2005 Apr 7, Volume 434, Issue 7034, p.724-31, (2005) Abstract
Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid., McClelland, Michael, Sanderson Kenneth E., Clifton Sandra W., Latreille Phil, Porwollik Steffen, Sabo Aniko, Meyer Rekha, Bieri Tamberlyn, Ozersky Phil, McLellan Michael, et al. , Nature genetics, 2004 Dec, Volume 36, Issue 12, p.1268-74, (2004) Abstract
EAnnot: a genome annotation tool using experimental evidence., Ding, Li, Sabo Aniko, Berkowicz Nicolas, Meyer Rekha R., Shotland Yoram, Johnson Mark R., Pepin Kymberlie H., Wilson Richard K., and Spieth John , Genome research, 2004 Dec, Volume 14, Issue 12, p.2503-9, (2004) Abstract
WormBase: a multi-species resource for nematode biology and genomics., Harris, Todd W., Chen Nansheng, Cunningham Fiona, Tello-Ruiz Marcela, Antoshechkin Igor, Bastiani Carol, Bieri Tamberlyn, Blasiar Darin, Bradnam Keith, Chan Juancarlos, et al. , Nucleic acids research, 2004 Jan 1, Volume 32, Issue Database issue, p.D411-7, (2004) Abstract

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