David Wheeler, Ph.D.

Professor, Department of Molecular and Human Genetics

image: David Wheeler, Ph.D.Contact Information

wheeler@bcm.edu

Publications

2020
Midorikawa Y, Yamamoto S, Tatsuno K, Renard-Guillet C, Tsuji S, Hayashi A, et al.. Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression. Cancer Res. 2020;80(18):3810-3819.

A Khan B, Gadot R, Shetty A, Bayley JC, Hadley CC, Cardenas MF, et al.. Identification of novel fusion transcripts in meningioma. J Neurooncol. 2020;149(2):219-230.

Conley BA, Staudt L, Takebe N, Wheeler DA, Wang L, Cardenas MF, et al.. The Exceptional Responders Initiative: Feasibility of A National Cancer Institute Pilot Study. J Natl Cancer Inst. 2020;.

Bailey MH, Meyerson WU, Dursi LJonathan, Wang L-B, Dong G, Liang W-W, et al.. Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nat Commun. 2020;11(1):4748.

Koneru B, Lopez G, Farooqi A, Conkrite KL, Nguyen TH, Macha SJ, et al.. Telomere Maintenance Mechanisms Define Clinical Outcome in High-Risk Neuroblastoma. Cancer Res. 2020;80(12):2663-2675.

Reyna MA, Haan D, Paczkowska M, Verbeke LPC, Vazquez M, Kahraman A, et al.. Pathway and network analysis of more than 2500 whole cancer genomes. Nat Commun. 2020;11(1):729.

Rheinbay E, Nielsen MMuhlig, Abascal F, Wala JA, Shapira O, Tiao G, et al.. Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. Nature. 2020;578(7793):102-111.

Alexandrov LB, Kim J, Haradhvala NJ, Huang MNi, Ng AWei Tian, Wu Y, et al.. The repertoire of mutational signatures in human cancer. Nature. 2020;578(7793):94-101.

2019
Rokita JLynne, Rathi KS, Cardenas MF, Upton KA, Jayaseelan J, Cross KL, et al.. Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design. Cell Rep. 2019;29(6):1675-1689.e9.

Patel AJ, Wan Y-W, Al-Ouran R, Revelli J-P, Cardenas MF, Oneissi M, et al.. Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors. Proc Natl Acad Sci U S A. 2019;116(43):21715-21726.

Donehower LA, Soussi T, Korkut A, Liu Y, Schultz A, Cardenas M, et al.. Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas. Cell Rep. 2019;28(5):1370-1384.e5.

Oak N, Ghosh R, Huang K-L, Wheeler DA, Ding L, Plon SE. Framework for microRNA variant annotation and prioritization using human population and disease datasets. Hum Mutat. 2019;40(1):73-89.

2018
Greytak SR, Engel KB, Zmuda E, Casas-Silva E, Guan P, Hoadley KA, et al.. National Cancer Institute Biospecimen Evidence-Based Practices: Harmonizing Procedures for Nucleic Acid Extraction from Formalin-Fixed, Paraffin-Embedded Tissue. Biopreserv Biobank. 2018;16(4):247-250.

Shen H, Shih J, Hollern DP, Wang L, Bowlby R, Tickoo SK, et al.. Integrated Molecular Characterization of Testicular Germ Cell Tumors. Cell Rep. 2018;23(11):3392-3406.

Grasso CS, Giannakis M, Wells DK, Hamada T, Mu XJasmine, Quist M, et al.. Genetic Mechanisms of Immune Evasion in Colorectal Cancer. Cancer Discov. 2018;8(6):730-749.

Ding L, Bailey MH, Porta-Pardo E, Thorsson V, Colaprico A, Bertrand D, et al.. Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics. Cell. 2018;173(2):305-320.e10.

Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, et al.. Comprehensive Characterization of Cancer Driver Genes and Mutations. Cell. 2018;173(2):371-385.e18.

Knijnenburg TA, Wang L, Zimmermann MT, Chambwe N, Gao GF, Cherniack AD, et al.. Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas. Cell Rep. 2018;23(1):239-254.e6.

Ellrott K, Bailey MH, Saksena G, Covington KR, Kandoth C, Stewart C, et al.. Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines. Cell Syst. 2018;6(3):271-281.e7.

Chen J, Zaidi S, Rao S, Chen J-S, Phan L, Farci P, et al.. Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-β Pathway. Gastroenterology. 2018;154(1):195-210.