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David Wheeler, Ph.D.

Professor, Department of Molecular and Human Genetics

image: David Wheeler, Ph.D.Contact Information

wheeler@bcm.edu

 

 

 

 

 

 

Publications

Identification of genetic susceptibility to childhood cancer through analysis of genes in parallel., Plon, Sharon E., Wheeler David A., Strong Louise C., Tomlinson Gail E., Pirics Michael, Meng Qingchang, Cheung Hannah C., Begin Phyllis R., Muzny Donna M., Lewis Lora, et al. , Cancer genetics, 2011 Jan, Volume 204, Issue 1, p.19-25, (2011) Abstract
Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy., Klassen, Tara, Davis Caleb F., Goldman Alica, Burgess Dan, Chen Tim, Wheeler David, McPherson John, Bourquin Traci, Lewis Lora, Villasana Donna, et al. , Cell, 2011 Jun 24, Volume 145, Issue 7, p.1036-48, (2011) Abstract
TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum., Davis, Erica E., Zhang Qi, Liu Qin, Diplas Bill H., Davey Lisa M., Hartley Jane, Stoetzel Corinne, Szymanska Katarzyna, Ramaswami Gokul, Logan Clare V., et al. , Nature genetics, 2011 Mar, Volume 43, Issue 3, p.189-96, (2011) Abstract
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase., Sun, Tingting, Aceto Nicola, Meerbrey Kristen L., Kessler Jessica D., Zhou Chunshui, Migliaccio Ilenia, Nguyen Don X., Pavlova Natalya N., Botero Maria, Huang Jian, et al. , Cell, 2011 Mar 4, Volume 144, Issue 5, p.703-18, (2011) Abstract
Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer., Sano, Daisuke, Xie Tong-Xin, Ow Thomas J., Zhao Mei, Pickering Curtis R., Zhou Ge, Sandulache Vlad C., Wheeler David A., Gibbs Richard A., Caulin Carlos, et al. , Clinical cancer research : an official journal of the American Association for Cancer Research, 2011 Nov 1, Volume 17, Issue 21, p.6658-70, (2011) Abstract
Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion., Xi, Ruibin, Hadjipanayis Angela G., Luquette Lovelace J., Kim Tae-Min, Lee Eunjung, Zhang Jianhua, Johnson Mark D., Muzny Donna M., Wheeler David A., Gibbs Richard A., et al. , Proceedings of the National Academy of Sciences of the United States of America, 2011 Nov 15, Volume 108, Issue 46, p.E1128-36, (2011) Abstract
Resequencing of IRS2 reveals rare variants for obesity but not fasting glucose homeostasis in Hispanic children., Butte, Nancy F., Voruganti Saroja V., Cole Shelley A., Haack Karin, Comuzzie Anthony G., Muzny Donna M., Wheeler David A., Chang Kyle, Hawes Alicia, and Gibbs Richard A. , Physiological genomics, 2011 Sep 22, Volume 43, Issue 18, p.1029-37, (2011) Abstract
Deep resequencing reveals excess rare recent variants consistent with explosive population growth., Coventry, Alex, Bull-Otterson Lara M., Liu Xiaoming, Clark Andrew G., Maxwell Taylor J., Crosby Jacy, Hixson James E., Rea Thomas J., Muzny Donna M., Lewis Lora R., et al. , Nature communications, 2010, Volume 1, p.131, (2010) Abstract
Whole-genome sequencing in a patient with Charcot-Marie-Tooth neuropathy., Lupski, James R., Reid Jeffrey G., Gonzaga-Jauregui Claudia, Rio Deiros David, Chen David C. Y., Nazareth Lynne, Bainbridge Matthew, Dinh Huyen, Jing Chyn, Wheeler David A., et al. , The New England journal of medicine, 2010 Apr 1, Volume 362, Issue 13, p.1181-91, (2010) Abstract
A SNP discovery method to assess variant allele probability from next-generation resequencing data., Shen, Yufeng, Wan Zhengzheng, Coarfa Cristian, Drabek Rafal, Chen Lei, Ostrowski Elizabeth A., Liu Yue, Weinstock George M., Wheeler David A., Gibbs Richard A., et al. , Genome research, 2010 Feb, Volume 20, Issue 2, p.273-80, (2010) Abstract
Integrating common and rare genetic variation in diverse human populations., Altshuler, David M., Gibbs Richard A., Peltonen Leena, Altshuler David M., Gibbs Richard A., Peltonen Leena, Dermitzakis Emmanouil, Schaffner Stephen F., Yu Fuli, Peltonen Leena, et al. , Nature, 2010 Sep 2, Volume 467, Issue 7311, p.52-8, (2010) Abstract
The genome sequence of taurine cattle: a window to ruminant biology and evolution., Elsik, Christine G., Tellam Ross L., Worley Kim C., Gibbs Richard A., Muzny Donna M., Weinstock George M., Adelson David L., Eichler Evan E., Elnitski Laura, Guigó Roderic, et al. , Science (New York, N.Y.), 2009 Apr 24, Volume 324, Issue 5926, p.522-8, (2009) Abstract
Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds., Gibbs, Richard A., Taylor Jeremy F., Van Tassell Curtis P., Barendse William, Eversole Kellye A., Gill Clare A., Green Ronnie D., Hamernik Debora L., Kappes Steven M., Lien Sigbjørn, et al. , Science (New York, N.Y.), 2009 Apr 24, Volume 324, Issue 5926, p.528-32, (2009) Abstract
The genome sequence of taurine cattle: a window to ruminant biology and evolution., Elsik, Christine G., Tellam Ross L., Worley Kim C., Gibbs Richard A., Muzny Donna M., Weinstock George M., Adelson David L., Eichler Evan E., Elnitski Laura, Guigó Roderic, et al. , Science (New York, N.Y.), 2009 Apr 24, Volume 324, Issue 5926, p.522-8, (2009) Abstract
A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies., Khanna, Hemant, Davis Erica E., Murga-Zamalloa Carlos A., Estrada-Cuzcano Alejandro, Lopez Irma, den Hollander Anneke I., Zonneveld Marijke N., Othman Mohammad I., Waseem Naushin, Chakarova Christina F., et al. , Nature genetics, 2009 Jun, Volume 41, Issue 6, p.739-45, (2009) Abstract
Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease., Guo, Dong-Chuan, Papke Christina L., Tran-Fadulu Van, Regalado Ellen S., Avidan Nili, Johnson Ralph Jay, Kim Dong H., Pannu Hariyadarshi, Willing Marcia C., Sparks Elizabeth, et al. , American journal of human genetics, 2009 May, Volume 84, Issue 5, p.617-27, (2009) Abstract
Common and rare variants of DAOA in bipolar disorder., Maheshwari, Manjula, Shi Jiajun, Badner Judith A., Skol Andrew, Willour Virginia L., Muzny Donna M., Wheeler David A., Gerald Fowler R., Detera-Wadleigh Sevilla, McMahon Francis J., et al. , American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2009 Oct 5, Volume 150B, Issue 7, p.960-6, (2009) Abstract
Novel microRNA candidates and miRNA-mRNA pairs in embryonic stem (ES) cells., Gu, Peili, Reid Jeffrey G., Gao Xiaolian, Shaw Chad A., Creighton Chad, Tran Peter L., Zhou Xiaochuan, Drabek Rafal B., Steffen David L., Hoang David M., et al. , PloS one, 2008, Volume 3, Issue 7, p.e2548, (2008) Abstract
The complete genome of an individual by massively parallel DNA sequencing., Wheeler, David A., Srinivasan Maithreyan, Egholm Michael, Shen Yufeng, Chen Lei, McGuire Amy, He Wen, Chen Yi-Ju, Makhijani Vinod, Roth Thomas G., et al. , Nature, 2008 Apr 17, Volume 452, Issue 7189, p.872-6, (2008) Abstract
Somatic mutations affect key pathways in lung adenocarcinoma., Ding, Li, Getz Gad, Wheeler David A., Mardis Elaine R., McLellan Michael D., Cibulskis Kristian, Sougnez Carrie, Greulich Heidi, Muzny Donna M., Morgan Margaret B., et al. , Nature, 2008 Oct 23, Volume 455, Issue 7216, p.1069-75, (2008) Abstract
Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques., Hernandez, Ryan D., Hubisz Melissa J., Wheeler David A., Smith David G., Ferguson Betsy, Rogers Jeffrey, Nazareth Lynne, Indap Amit, Bourquin Traci, McPherson John, et al. , Science (New York, N.Y.), 2007 Apr 13, Volume 316, Issue 5822, p.240-3, (2007) Abstract
Evolutionary and biomedical insights from the rhesus macaque genome., Gibbs, Richard A., Rogers Jeffrey, Katze Michael G., Bumgarner Roger, Weinstock George M., Mardis Elaine R., Remington Karin A., Strausberg Robert L., Venter Craig J., Wilson Richard K., et al. , Science (New York, N.Y.), 2007 Apr 13, Volume 316, Issue 5822, p.222-34, (2007) Abstract
Characterizing the cancer genome in lung adenocarcinoma., Weir, Barbara A., Woo Michele S., Getz Gad, Perner Sven, Ding Li, Beroukhim Rameen, Lin William M., Province Michael A., Kraja Aldi, Johnson Laura A., et al. , Nature, 2007 Dec 6, Volume 450, Issue 7171, p.893-8, (2007) Abstract
Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome., Margulies, Elliott H., Cooper Gregory M., Asimenos George, Thomas Daryl J., Dewey Colin N., Siepel Adam, Birney Ewan, Keefe Damian, Schwartz Ariel S., Hou Minmei, et al. , Genome research, 2007 Jun, Volume 17, Issue 6, p.760-74, (2007) Abstract
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project., Birney, Ewan, Stamatoyannopoulos John A., Dutta Anindya, Guigó Roderic, Gingeras Thomas R., Margulies Elliott H., Weng Zhiping, Snyder Michael, Dermitzakis Emmanouil T., Thurman Robert E., et al. , Nature, 2007 Jun 14, Volume 447, Issue 7146, p.799-816, (2007) Abstract


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