David Wheeler, Ph.D.

Professor, Department of Molecular and Human Genetics

image: David Wheeler, Ph.D.Contact Information

wheeler@bcm.edu

Publications

2015
Ritter DI, Haines K, Cheung H, Davis CF, Lau CC, Berg JS, et al.. Identifying gene disruptions in novel balanced de novo constitutional translocations in childhood cancer patients by whole-genome sequencing. Genet Med. 2015;17(10):831-5.

Roy A, Kumar V, Zorman B, Fang E, Haines KM, Doddapaneni H, et al.. Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney. Nat Commun. 2015;6:8891.

Zhao C, Escalante LNavarro, Chen H, Benatti TR, Qu J, Chellapilla S, et al.. A massive expansion of effector genes underlies gall-formation in the wheat pest Mayetiola destructor. Curr Biol. 2015;25(5):613-20.

Ma X, Edmonson M, Yergeau D, Muzny DM, Hampton OA, Rusch M, et al.. Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia. Nat Commun. 2015;6:6604.

Mayle A, Yang L, Rodriguez B, Zhou T, Chang E, Curry CV, et al.. Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. Blood. 2015;125(4):629-38.

Smith MA, Hampton OA, C Reynolds P, Kang MH, Maris JM, Gorlick R, et al.. Initial testing (stage 1) of the PARP inhibitor BMN 673 by the pediatric preclinical testing program: PALB2 mutation predicts exceptional in vivo response to BMN 673. Pediatr Blood Cancer. 2015;62(1):91-8.

Walz AL, Ooms A, Gadd S, Gerhard DS, Smith MA, Auvil JMGuidry, et al.. Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors. Cancer Cell. 2015;27(2):286-97.

Alioto TS, Buchhalter I, Derdak S, Hutter B, Eldridge MD, Hovig E, et al.. A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing. Nat Commun. 2015;6:10001.

Wang L, Ni X, Covington KR, Yang BY, Shiu J, Zhang X, et al.. Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes. Nat Genet. 2015;47(12):1426-34.

English AC, Salerno WJ, Hampton OA, Gonzaga-Jauregui C, Ambreth S, Ritter DI, et al.. Assessing structural variation in a personal genome-towards a human reference diploid genome. BMC Genomics. 2015;16:286.

Peters TL, Kumar V, Polikepahad S, Lin FY, Sarabia SF, Liang Y, et al.. BCOR-CCNB3 fusions are frequent in undifferentiated sarcomas of male children. Mod Pathol. 2015;28(4):575-86.

2014
Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, et al.. The somatic genomic landscape of chromophobe renal cell carcinoma. Cancer Cell. 2014;26(3):319-30.

Parfenov M, Pedamallu CSekhar, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, et al.. Characterization of HPV and host genome interactions in primary head and neck cancers. Proc Natl Acad Sci U S A. 2014;111(43):15544-9.

Chakraborty R, Hampton OA, Shen X, Simko SJ, Shih A, Abhyankar H, et al.. Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis. Blood. 2014;124(19):3007-15.

Xia Z, Donehower LA, Cooper TA, Neilson JR, Wheeler DA, Wagner EJ, et al.. Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types. Nat Commun. 2014;5:5274.

Shinbrot E, Henninger EE, Weinhold N, Covington KR, A Göksenin Y, Schultz N, et al.. Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication. Genome Res. 2014;24(11):1740-50.

Pickering CR, Zhang J, Neskey DM, Zhao M, Jasser SA, Wang J, et al.. Squamous cell carcinoma of the oral tongue in young non-smokers is genomically similar to tumors in older smokers. Clin Cancer Res. 2014;20(14):3842-8.

Wang L, Yamaguchi S, Burstein MD, Terashima K, Chang K, Ng H-K, et al.. Novel somatic and germline mutations in intracranial germ cell tumours. Nature. 2014;511(7508):241-5.

Pickering CR, Zhou JH, J Lee J, Drummond JA, S Peng A, Saade RE, et al.. Mutational landscape of aggressive cutaneous squamous cell carcinoma. Clin Cancer Res. 2014;20(24):6582-92.

Totoki Y, Tatsuno K, Covington KR, Ueda H, Creighton CJ, Kato M, et al.. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes. Nat Genet. 2014;46(12):1267-73.