David Wheeler, Ph.D.

Professor, Department of Molecular and Human Genetics

image: David Wheeler, Ph.D.Contact Information

wheeler@bcm.edu

Publications

2014
Parikh N, Hilsenbeck S, Creighton CJ, Dayaram T, Shuck R, Shinbrot E, et al.. Effects of TP53 mutational status on gene expression patterns across 10 human cancer types. J Pathol. 2014;232(5):522-33.

Wang L, Swierczek SI, Lanikova L, Kim SJ, Hickman K, Walker K, et al.. The relationship of JAK2(V617F) and acquired UPD at chromosome 9p in polycythemia vera. Leukemia. 2014;28(4):938-41.

Wang L, Swierczek SI, Drummond J, Hickman K, Kim SJ, Walker K, et al.. Whole-exome sequencing of polycythemia vera revealed novel driver genes and somatic mutation shared by T cells and granulocytes. Leukemia. 2014;28(4):935-8.

Wang L, Wheeler DA. Genomic sequencing for cancer diagnosis and therapy. Annu Rev Med. 2014;65:33-48.

Takahashi Y, Pickering CR, Gelbard A, Drummond JA, Wheeler DA, Kupferman ME, et al.. Genomic Characterization of Sinonasal Undifferentiated Carcinoma. J Neurol Surg B. 2014;75:A084.

2013
Shah S, Schrader KA, Waanders E, Timms AE, Vijai J, Miething C, et al.. A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. Nat Genet. 2013;45(10):1226-31.

Powell BC, Jiang L, Muzny DM, Treviño LR, Dreyer ZE, Strong LC, et al.. Identification of TP53 as an acute lymphocytic leukemia susceptibility gene through exome sequencing. Pediatr Blood Cancer. 2013;60(6):E1-3.

Pickering CR, Zhang J, Yoo SYoung, Bengtsson L, Moorthy S, Neskey DM, et al.. Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov. 2013;3(7):770-81.

Wheeler DA, Wang L. From human genome to cancer genome: the first decade. Genome Res. 2013;23(7):1054-62.

Baud A, Hermsen R, Guryev V, Stridh P, Graham D, McBride MW, et al.. Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nat Genet. 2013;45(7):767-75.

Donehower LA, Creighton CJ, Schultz N, Shinbrot E, Chang K, Gunaratne PH, et al.. MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes. J Pathol. 2013;229(1):99-110.

Crowley JJ, Hilliard CE, Kim Y, Morgan MB, Lewis LR, Muzny DM, et al.. Deep resequencing and association analysis of schizophrenia candidate genes. Mol Psychiatry. 2013;18(2):138-40.

Midorikawa Y, Takayama T, Yamamoto S, Ueda H, Sonoda K, Takane K, et al.. Genome-wide analysis of stepwise hepatocarcinogenesis using next generation sequencer. In AACR 104th Annual Meeting 2013. Washington, DC: Cancer Res; 2013.

2012
Biankin AV, Waddell N, Kassahn KS, Gingras M-C, Muthuswamy LB, Johns AL, et al.. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature. 2012;491(7424):399-405.

Lee E, Iskow R, Yang L, Gokcumen O, Haseley P, Luquette LJ, et al.. Landscape of somatic retrotransposition in human cancers. Science. 2012;337(6097):967-71.

Creighton CJ, Hernandez-Herrera A, Jacobsen A, Levine DA, Mankoo P, Schultz N, et al.. Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma. PLoS One. 2012;7(3):e34546.

2011
Butte NF, V Voruganti S, Cole SA, Haack K, Comuzzie AG, Muzny DM, et al.. Resequencing of IRS2 reveals rare variants for obesity but not fasting glucose homeostasis in Hispanic children. Physiol Genomics. 2011;43(18):1029-37.

Xi R, Hadjipanayis AG, Luquette LJ, Kim T-M, Lee E, Zhang J, et al.. Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion. Proc Natl Acad Sci U S A. 2011;108(46):E1128-36.

Sano D, Xie T-X, Ow TJ, Zhao M, Pickering CR, Zhou G, et al.. Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer. Clin Cancer Res. 2011;17(21):6658-70.

Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, et al.. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 2011;144(5):703-18.