David Wheeler, Ph.D.

Professor, Department of Molecular and Human Genetics

image: David Wheeler, Ph.D.Contact Information

wheeler@bcm.edu

Publications

2014
Parfenov M, Pedamallu CSekhar, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, et al.. Characterization of HPV and host genome interactions in primary head and neck cancers. Proc Natl Acad Sci U S A. 2014;111(43):15544-9.

Chakraborty R, Hampton OA, Shen X, Simko SJ, Shih A, Abhyankar H, et al.. Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis. Blood. 2014;124(19):3007-15.

Xia Z, Donehower LA, Cooper TA, Neilson JR, Wheeler DA, Wagner EJ, et al.. Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types. Nat Commun. 2014;5:5274.

Shinbrot E, Henninger EE, Weinhold N, Covington KR, A Göksenin Y, Schultz N, et al.. Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication. Genome Res. 2014;24(11):1740-50.

Pickering CR, Zhang J, Neskey DM, Zhao M, Jasser SA, Wang J, et al.. Squamous cell carcinoma of the oral tongue in young non-smokers is genomically similar to tumors in older smokers. Clin Cancer Res. 2014;20(14):3842-8.

Wang L, Yamaguchi S, Burstein MD, Terashima K, Chang K, Ng H-K, et al.. Novel somatic and germline mutations in intracranial germ cell tumours. Nature. 2014;511(7508):241-5.

Pickering CR, Zhou JH, J Lee J, Drummond JA, S Peng A, Saade RE, et al.. Mutational landscape of aggressive cutaneous squamous cell carcinoma. Clin Cancer Res. 2014;20(24):6582-92.

Totoki Y, Tatsuno K, Covington KR, Ueda H, Creighton CJ, Kato M, et al.. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes. Nat Genet. 2014;46(12):1267-73.

Wang L, Swierczek SI, Drummond J, Hickman K, Kim SJ, Walker K, et al.. Whole-exome sequencing of polycythemia vera revealed novel driver genes and somatic mutation shared by T cells and granulocytes. Leukemia. 2014;28(4):935-8.

Parikh N, Hilsenbeck S, Creighton CJ, Dayaram T, Shuck R, Shinbrot E, et al.. Effects of TP53 mutational status on gene expression patterns across 10 human cancer types. J Pathol. 2014;232(5):522-33.

Wang L, Swierczek SI, Lanikova L, Kim SJ, Hickman K, Walker K, et al.. The relationship of JAK2(V617F) and acquired UPD at chromosome 9p in polycythemia vera. Leukemia. 2014;28(4):938-41.

Wang L, Wheeler DA. Genomic sequencing for cancer diagnosis and therapy. Annu Rev Med. 2014;65:33-48.

Takahashi Y, Pickering CR, Gelbard A, Drummond JA, Wheeler DA, Kupferman ME, et al.. Genomic Characterization of Sinonasal Undifferentiated Carcinoma. J Neurol Surg B. 2014;75:A084.

2013
Shah S, Schrader KA, Waanders E, Timms AE, Vijai J, Miething C, et al.. A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. Nat Genet. 2013;45(10):1226-1231.

Powell BC, Jiang L, Muzny DM, Treviño LR, Dreyer ZE, Strong LC, et al.. Identification of TP53 as an acute lymphocytic leukemia susceptibility gene through exome sequencing. Pediatr Blood Cancer. 2013;60(6):E1-3.

Baud A, Hermsen R, Guryev V, Stridh P, Graham D, McBride MW, et al.. Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nat Genet. 2013;45(7):767-75.

Pickering CR, Zhang J, Yoo SYoung, Bengtsson L, Moorthy S, Neskey DM, et al.. Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov. 2013;3(7):770-81.

Wheeler DA, Wang L. From human genome to cancer genome: the first decade. Genome Res. 2013;23(7):1054-62.

Donehower LA, Creighton CJ, Schultz N, Shinbrot E, Chang K, Gunaratne PH, et al.. MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes. J Pathol. 2013;229(1):99-110.

Crowley JJ, Hilliard CE, Kim Y, Morgan MB, Lewis LR, Muzny DM, et al.. Deep resequencing and association analysis of schizophrenia candidate genes. Mol Psychiatry. 2013;18(2):138-40.