David Wheeler, Ph.D.

Professor, Department of Molecular and Human Genetics

image: David Wheeler, Ph.D.Contact Information

wheeler@bcm.edu

Publications

2013
Pickering CR, Zhang J, Yoo SYoung, Bengtsson L, Moorthy S, Neskey DM, et al.. Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov. 2013;3(7):770-81.

Donehower LA, Creighton CJ, Schultz N, Shinbrot E, Chang K, Gunaratne PH, et al.. MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes. J Pathol. 2013;229(1):99-110.

Crowley JJ, Hilliard CE, Kim Y, Morgan MB, Lewis LR, Muzny DM, et al.. Deep resequencing and association analysis of schizophrenia candidate genes. Mol Psychiatry. 2013;18(2):138-40.

Midorikawa Y, Takayama T, Yamamoto S, Ueda H, Sonoda K, Takane K, et al.. Genome-wide analysis of stepwise hepatocarcinogenesis using next generation sequencer. In AACR 104th Annual Meeting 2013. Washington, DC: Cancer Res; 2013.

2012
Biankin AV, Waddell N, Kassahn KS, Gingras M-C, Muthuswamy LB, Johns AL, et al.. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature. 2012;491(7424):399-405.

Lee E, Iskow R, Yang L, Gokcumen O, Haseley P, Luquette LJ, et al.. Landscape of somatic retrotransposition in human cancers. Science. 2012;337(6097):967-71.

Creighton CJ, Hernandez-Herrera A, Jacobsen A, Levine DA, Mankoo P, Schultz N, et al.. Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma. PLoS One. 2012;7(3):e34546.

2011
Butte NF, V Voruganti S, Cole SA, Haack K, Comuzzie AG, Muzny DM, et al.. Resequencing of IRS2 reveals rare variants for obesity but not fasting glucose homeostasis in Hispanic children. Physiol Genomics. 2011;43(18):1029-37.

Xi R, Hadjipanayis AG, Luquette LJ, Kim T-M, Lee E, Zhang J, et al.. Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion. Proc Natl Acad Sci U S A. 2011;108(46):E1128-36.

Sano D, Xie T-X, Ow TJ, Zhao M, Pickering CR, Zhou G, et al.. Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer. Clin Cancer Res. 2011;17(21):6658-70.

Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, et al.. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 2011;144(5):703-18.

Davis EE, Zhang Q, Liu Q, Diplas BH, Davey LM, Hartley J, et al.. TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum. Nat Genet. 2011;43(3):189-96.

Klassen T, Davis C, Goldman A, Burgess D, Chen T, Wheeler DA, et al.. Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy. Cell. 2011;145(7):1036-48.

Fawcett GL, Raveendran M, Deiros DRio, Chen D, Yu F, Harris RA, et al.. Characterization of single-nucleotide variation in Indian-origin rhesus macaques (Macaca mulatta). BMC Genomics. 2011;12:311.

Plon SE, Wheeler DA, Strong LC, Tomlinson GE, Pirics M, Meng Q, et al.. Identification of genetic susceptibility to childhood cancer through analysis of genes in parallel. Cancer Genet. 2011;204(1):19-25.

Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, et al.. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011;333(6046):1154-7.

N Nguyen TT, Cotton RT, Harring TR, Guiteau JJ, Gingras M-C, Wheeler DA, et al.. A primer on a hepatocellular carcinoma bioresource bank using the cancer genome atlas guidelines: practical issues and pitfalls. World J Surg. 2011;35(8):1732-7.

Harring TR, Guiteau JJ, N Nguyen TT, Cotton RT, Gingras M-C, Wheeler DA, et al.. Building a comprehensive genomic program for hepatocellular carcinoma. World J Surg. 2011;35(8):1746-50.

2010
Altshuler DM, Gibbs RA, Peltonen L, Altshuler DM, Gibbs RA, Peltonen L, et al.. Integrating common and rare genetic variation in diverse human populations. Nature. 2010;467(7311):52-8.

Coventry A, Bull-Otterson LM, Liu X, Clark AG, Maxwell TJ, Crosby J, et al.. Deep resequencing reveals excess rare recent variants consistent with explosive population growth. Nat Commun. 2010;1:131.