Kim C. Worley, Ph.D.

Professor, Department of Molecular and Human Genetics

image: Kim Worley, Ph.D.Contact information

kworley@bcm.edu

Education

Postdoc, Baylor College of Medicine, 1997

Ph.D., Baylor College of Medicine, 1993

B.S., Massachusetts Institute of Technology, 1984

Awards and honors

1989: Predoctoral training grant, National Eye Institute, National Institutes of Health

1993: Postdoctoral Fellowship, W.M. Keck Center for Computational Biology, National Library of Medicine

1993: Participant, Essential Computational Genomics for Biologists, Cold Spring Harbor Laboratory

1995: National Research Service Award Postdoctoral Fellowship, National Center for Human Genome Research, National Institutes of Health

2010: IBM Faculty Award, IBM Corporation

Research interests

Computational biology, especially computer methods for analysis of genomic sequence information; bioinformatics, developing new tools to improve genomic sequence assembly, analysis and annotation.

Publications

2006
Elsik CG, Worley KC, Zhang L, Milshina NV, Jiang H, Reese JT, et al.. Community annotation: procedures, protocols, and supporting tools. Genome Res. 2006;16(11):1329-33.

Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, et al.. The finished DNA sequence of human chromosome 12. Nature. 2006;440(7082):346-51.

Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, et al.. The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006;440(7088):1194-8.

2005
Ross MT, Grafham DV, Coffey AJ, Scherer SE, McLay K, Muzny DM, et al.. The DNA sequence of the human X chromosome. Nature. 2005;434(7031):325-37.

Richards S, Liu Y, Bettencourt BR, Hradecky P, Letovsky S, Nielsen R, et al.. Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. Genome Res. 2005;15(1):1-18.

2004
Levenson JM, Choi S, Lee S-Y, Cao YAnna, Ahn HJin, Worley KC, et al.. A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-rel. J Neurosci. 2004;24(16):3933-43.

Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer SE, et al.. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature. 2004;428(6982):493-521.

2003
Gunaratne PH, Wu JQian, Garcia AM, Hulyk S, Worley KC, Margolin JF, et al.. Concatenation cDNA sequencing for transcriptome analysis. C R Biol. 2003;326(10-11):971-7.

2002
Katsanis N, Worley KC, Gonzalez G, Ansley SJ, Lupski JR. A computational/functional genomics approach for the enrichment of the retinal transcriptome and the identification of positional candidate retinopathy genes. Proc Natl Acad Sci U S A. 2002;99(22):14326-31.

Wang LL, Worley KC, Gannavarapu A, Chintagumpala MM, Levy ML, Plon SE. Intron-size constraint as a mutational mechanism in Rothmund-Thomson syndrome. Am J Hum Genet. 2002;71(1):165-7.

Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al.. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002;99(26):16899-903.

2001
Katsanis N, Worley KC, Lupski JR. An evaluation of the draft human genome sequence. Nat Genet. 2001;29(1):88-91.

2000
Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, et al.. The genome sequence of Drosophila melanogaster. Science. 2000;287(5461):2185-95.

Bouck J, McLeod MP, Worley KC, Gibbs RA. The human transcript database: a catalogue of full length cDNA inserts. Bioinformatics. 2000;16(2):176-7.

Zhang Y, Dipple KM, Vilain E, Huang BL, Finlayson G, Therrell BL, et al.. AluY insertion (IVS4-52ins316alu) in the glycerol kinase gene from an individual with benign glycerol kinase deficiency. Hum Mutat. 2000;15(4):316-23.

1999
Bouck J, Yu W, Gibbs RA, Worley KC. Comparison of gene indexing databases. Trends Genet. 1999;15(4):159-62.

1998
Worley KC, Culpepper P, Wiese BA, Smith RF. BEAUTY-X: enhanced BLAST searches for DNA queries. Bioinformatics. 1998;14(10):890-1.

1996
Smith RF, Wiese BA, Wojzynski MK, Davison DB, Worley KC. BCM Search Launcher--an integrated interface to molecular biology data base search and analysis services available on the World Wide Web. Genome Res. 1996;6(5):454-62.

Levin ML, Chatterjee A, Pragliola A, Worley KC, Wehnert M, Zhuchenko O, et al.. A comparative transcription map of the murine bare patches (Bpa) and striated (Str) critical regions and human Xq28. Genome Res. 1996;6(6):465-77.

1995
Worley KC, Wiese BA, Smith RF. BEAUTY: an enhanced BLAST-based search tool that integrates multiple biological information resources into sequence similarity search results. Genome Res. 1995;5(2):173-84.