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Rat Genome Project

image: rat
Image source: Reg Mckenna (originally posted to Flickr as Wild Rat) [CC-BY-2.0], via Wikimedia Commons

About the Project

The genome of the Brown Norway rat (Rattus norvegicus) was sequenced by the Rat Genome Sequencing Consortium (RGSC) led by the BCM-HGSC. (1)

This rat is important as a model organism for cardiovascular and psychological research, and has a legacy of decades of study of its physiology in academia and industry.

The BCM-HGSC is currently upgrading the rat genome sequence through various activities. These include finishing BAC clones and selected other regions of the genome, and sequencing of the Y chromosome. 

In addition, a new assembly was produced that incorporates sequence from SOLiD data from the Edwin Cuppen's laboratory.

Early funding for the RGSC came from the National Heart, Lung, and Blood Institute (NHLBI) and the National Human Genome Research Institute (NHGRI) and subsequent activities are supported by the NHGRI.



Genomic Resources

Access to the Data 

BAC-based Data Resources

Additional Resources

Related Publications

Integrated and sequence-ordered BAC- and YAC-based physical maps for the rat genome., Krzywinski, Martin, Wallis John, Gösele Claudia, Bosdet Ian, Chiu Readman, Graves Tina, Hummel Oliver, Layman Dan, Mathewson Carrie, Wye Natasja, et al. , Genome research, 2004 Apr, Volume 14, Issue 4, p.766-79, (2004) Abstract
Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome., Zhang, Zhengdong, Burch Paula E., Cooney Austin J., Lanz Rainer B., Pereira Fred A., Wu Jiaqian, Gibbs Richard A., Weinstock George, and Wheeler David A. , Genome research, 2004 Apr, Volume 14, Issue 4, p.580-90, (2004) Abstract
Genome sequence of the Brown Norway rat yields insights into mammalian evolution., Gibbs, Richard A., Weinstock George M., Metzker Michael L., Muzny Donna M., Sodergren Erica J., Scherer Steven, Scott Graham, Steffen David, Worley Kim C., Burch Paula E., et al. , Nature, 2004 Apr 1, Volume 428, Issue 6982, p.493-521, (2004) Abstract
Glass bead purification of plasmid template DNA for high throughput sequencing of mammalian genomes., Dederich, Debra A., Okwuonu Geoffrey, Garner Toni, Denn Amanda, Sutton Angelica, Escotto Michael, Martindale Ashley, Delgado Oliver, Muzny Donna M., Gibbs Richard A., et al. , Nucleic acids research, 2002 Apr 1, Volume 30, Issue 7, p.e32, (2002) Abstract
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